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| TissGeneSummary for OPLAH |
 Gene summary |
| Basic gene information | Gene symbol | OPLAH |
| Gene name | 5-oxoprolinase (ATP-hydrolysing) | |
| Synonyms | 5-Opase|OPLA|OPLAHD | |
| Cytomap | UCSC genome browser: 8q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017570.4, | |
| Description | 5-oxo-L-prolinase5-oxoprolinasepyroglutamase | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 614243 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000178814 | ||
| HPRD : 14880 | ||
| Vega : OTTHUMG00000165435 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OPLAH | |
| BioGPS: 26873 | ||
| Pathway | NCI Pathway Interaction Database: OPLAH | |
| KEGG: OPLAH | ||
| REACTOME: OPLAH | ||
| Pathway Commons: OPLAH | ||
| Context | iHOP: OPLAH | |
| ligand binding site mutation search in PubMed: OPLAH | ||
| UCL Cancer Institute: OPLAH | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
| Reference showing the relevant tissue of OPLAH | ||
| Description by TissGene annotations | Risk TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OPLAH |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.832636991 | 0.777425226 | 1.055211765 | 1.56E-10 | 5.76E-10 |
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| TissGene-miRNA for OPLAH |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OPLAH |
| TissGeneSNV for OPLAH |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P1062S | SKCM | 2 |
| p.E647K | COAD | 2 |
| p.V1089I | ACC | 2 |
| p.A900D | TGCT | 2 |
| p.R31Q | BRCA | 2 |
| p.S720F | SKCM | 2 |
| p.G316E | HNSC | 1 |
| p.P407L | SKCM | 1 |
| p.G145A | HNSC | 1 |
| p.S283F | BLCA | 1 |
| p.Y302C | LUAD | 1 |
| p.R384C | LUSC | 1 |
| p.A900D | HNSC | 1 |
| p.A44T | STAD | 1 |
| p.V527M | STAD | 1 |
| p.D922Y | COAD | 1 |
| p.V1057A | STAD | 1 |
| p.P869L | SKCM | 1 |
| p.A41D | PAAD | 1 |
| p.S284R | UVM | 1 |
| p.R969C | STAD | 1 |
| p.D831H | LUSC | 1 |
| p.G865C | LUSC | 1 |
| p.A523T | LUAD | 1 |
| p.S536F | SKCM | 1 |
| p.G521V | STAD | 1 |
| p.A903V | GBM | 1 |
| p.R758C | UCEC | 1 |
| p.G669E | SKCM | 1 |
| p.R115C | SKCM | 1 |
| p.T712A | KIRP | 1 |
| p.C236F | STAD | 1 |
| p.S699I | UCEC | 1 |
| p.A760S | LUAD | 1 |
| p.A496T | LGG | 1 |
| p.R247H | COAD | 1 |
| p.E575* | LUAD | 1 |
| p.G251D | SKCM | 1 |
| p.A900D | LIHC | 1 |
| p.K906N | LUAD | 1 |
| p.V294M | COAD | 1 |
| p.D1255N | SKCM | 1 |
| p.S284R | BRCA | 1 |
| p.Q737* | SKCM | 1 |
| p.R227C | SARC | 1 |
| p.A1126T | MESO | 1 |
| p.S423F | SKCM | 1 |
| p.R581H | STAD | 1 |
| p.G327E | LUAD | 1 |
| p.E463K | LIHC | 1 |
| p.D1147Y | HNSC | 1 |
| p.E56K | SKCM | 1 |
| p.V721L | COAD | 1 |
| p.S284R | COAD | 1 |
| p.N415K | STAD | 1 |
| p.R581H | LGG | 1 |
| p.G640S | ESCA | 1 |
| p.G251S | SKCM | 1 |
| p.E681* | LUAD | 1 |
| p.P1018R | BRCA | 1 |
| p.A482V | SKCM | 1 |
| p.S419F | SKCM | 1 |
| p.A1074V | COAD | 1 |
| p.G232E | SKCM | 1 |
| p.G889R | SKCM | 1 |
| p.P813L | SKCM | 1 |
| p.G683D | STAD | 1 |
| p.Q565H | LUAD | 1 |
| p.G312S | COAD | 1 |
| p.V964M | LUSC | 1 |
| p.A1074V | STAD | 1 |
| p.D607N | SKCM | 1 |
| p.G148A | KIRP | 1 |
| p.R924H | UCEC | 1 |
| p.R997C | DLBC | 1 |
| p.R102H | COAD | 1 |
| p.D1258N | HNSC | 1 |
| p.E894K | PAAD | 1 |
| p.V391G | SKCM | 1 |
| p.D922H | LUAD | 1 |
| p.A394T | LIHC | 1 |
| p.R768H | ESCA | 1 |
| p.A900D | KICH | 1 |
| p.D810N | SKCM | 1 |
| p.P4L | SKCM | 1 |
| p.A75T | PAAD | 1 |
| p.G232R | SKCM | 1 |
| p.R424H | LUSC | 1 |
| p.R384C | LGG | 1 |
| p.R91G | KIRC | 1 |
| p.Q67X | LIHC | 1 |
| p.E575K | BLCA | 1 |
| p.G1179D | STAD | 1 |
| p.R1063Q | COAD | 1 |
| p.S358Y | BLCA | 1 |
| p.D586E | COAD | 1 |
| p.S220L | SKCM | 1 |
| p.H495N | STAD | 1 |
| p.R1160H | CESC | 1 |
| p.R604H | LUAD | 1 |
| p.P1062L | SKCM | 1 |
| p.A900D | STAD | 1 |
| p.G258C | STAD | 1 |
| p.R185H | LIHC | 1 |
| p.Q931R | DLBC | 1 |
| p.S284R | PCPG | 1 |
| p.R604H | KIRP | 1 |
| p.E177D | KIRC | 1 |
| p.H1275Y | LUAD | 1 |
| p.R459C | COAD | 1 |
| p.I755M | BRCA | 1 |
| p.R139C | ESCA | 1 |
| p.P1211A | LIHC | 1 |
| p.Y1279H | HNSC | 1 |
| p.H596Q | COAD | 1 |
| p.R1165W | PRAD | 1 |
| p.R78C | SKCM | 1 |
| p.P657S | SKCM | 1 |
| p.G825R | STAD | 1 |
| p.R758H | ESCA | 1 |
| p.R424H | UCEC | 1 |
| p.T1016S | BRCA | 1 |
| p.C665R | STAD | 1 |
| p.D632E | THYM | 1 |
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| TissGeneCNV for OPLAH |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OPLAH |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for OPLAH |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| COAD (tumor) | COAD (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| HNSC (tumor) | HNSC (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| KICH (tumor) | KICH (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| KIRC (tumor) | KIRC (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| KIRP (tumor) | KIRP (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| LIHC (tumor) | LIHC (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| LUAD (tumor) | LUAD (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| LUSC (tumor) | LUSC (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| PRAD (tumor) | PRAD (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| STAD (tumor) | STAD (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| THCA (tumor) | THCA (normal) |
| OPLAH, GK (tumor) | OPLAH, GK (normal) |
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| TissGeneProg for OPLAH |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OPLAH |
| TissGeneDrug for OPLAH |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for OPLAH |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0268525 | 5-oxoprolinase deficiency | 2 | BeFree,CLINVAR,ORPHANET |
| umls:C0398746 | Gluthathione synthetase deficiency | 1 | BeFree |
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