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| TissGeneSummary for GIF |
 Gene summary |
| Basic gene information | Gene symbol | GIF |
| Gene name | gastric intrinsic factor (vitamin B synthesis) | |
| Synonyms | IF|IFMH|INF|TCN3 | |
| Cytomap | UCSC genome browser: 11q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005142.2, | |
| Description | gastric intrinsic factorintrinsic factor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609342 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134812 | ||
| HPRD : 02024 | ||
| Vega : OTTHUMG00000167399 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GIF | |
| BioGPS: 2694 | ||
| Pathway | NCI Pathway Interaction Database: GIF | |
| KEGG: GIF | ||
| REACTOME: GIF | ||
| Pathway Commons: GIF | ||
| Context | iHOP: GIF | |
| ligand binding site mutation search in PubMed: GIF | ||
| UCL Cancer Institute: GIF | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of GIF | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GIF |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 2.905158611 | 6.398364861 | -3.49320625 | 0.00947 | 0.033020202 |
| COAD | 2.655178563 | 0.423013178 | 2.232165385 | 0.000552 | 0.001677437 |
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| TissGene-miRNA for GIF |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GIF |
| TissGeneSNV for GIF |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S365Y | UCEC | 2 |
| p.A39S | LUAD | 1 |
| p.R327H | ESCA | 1 |
| p.K233M | BLCA | 1 |
| p.K258T | SKCM | 1 |
| p.W3* | HNSC | 1 |
| p.A35D | SKCM | 1 |
| p.S300R | HNSC | 1 |
| p.E148Q | BLCA | 1 |
| p.M252I | SKCM | 1 |
| p.C288Y | ESCA | 1 |
| p.M227I | SKCM | 1 |
| p.L389I | READ | 1 |
| p.M55I | PRAD | 1 |
| p.P239S | COAD | 1 |
| p.S19R | ESCA | 1 |
| p.Y280X | ESCA | 1 |
| p.G218D | READ | 1 |
| p.T359R | SKCM | 1 |
| p.N146K | COAD | 1 |
| p.Y77* | LUSC | 1 |
| p.P34H | COAD | 1 |
| p.A352V | PAAD | 1 |
| p.K216E | LGG | 1 |
| p.V155I | COAD | 1 |
| p.P369T | LUAD | 1 |
| p.D180N | SKCM | 1 |
| p.A138P | ESCA | 1 |
| p.N309H | LUAD | 1 |
| p.A113P | ESCA | 1 |
| p.K233T | SKCM | 1 |
| p.N126K | KIRP | 1 |
| p.T384R | SKCM | 1 |
| p.A377V | PAAD | 1 |
| p.G342S | SKCM | 1 |
| p.S200R | BLCA | 1 |
| p.L94I | LUSC | 1 |
| p.A96E | SARC | 1 |
| p.Y199* | THCA | 1 |
| p.S124N | SKCM | 1 |
| p.E323Q | HNSC | 1 |
| p.R131C | HNSC | 1 |
| p.E123Q | BLCA | 1 |
| p.P290T | UCEC | 1 |
| p.I153L | OV | 1 |
| p.T75N | LUAD | 1 |
| p.I287V | SARC | 1 |
| p.R131G | LUAD | 1 |
| p.H409R | PAAD | 1 |
| p.E348Q | HNSC | 1 |
| p.H384R | PAAD | 1 |
| p.P135H | GBM | 1 |
| p.W219* | SKCM | 1 |
| p.C221Y | LUAD | 1 |
| p.P394T | LUAD | 1 |
| p.R352H | STAD | 1 |
| p.V85L | CESC | 1 |
| p.S275R | HNSC | 1 |
| p.V258G | LUAD | 1 |
| p.D83N | ESCA | 1 |
| p.A64S | LUAD | 1 |
| p.G342D | SKCM | 1 |
| p.T18I | COAD | 1 |
| p.P142S | SKCM | 1 |
| p.A138V | READ | 1 |
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| TissGeneCNV for GIF |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GIF |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | M63154 | PIGR-GIF | chr1:207105925 | chr11:59596748 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A8W5-01B | OSBP-GIF | In-Frame | chr11:59361076 | chr11:59597018 |
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| TissGeneNet for GIF |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| COAD (tumor) | COAD (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| KICH (tumor) | KICH (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| STAD (tumor) | STAD (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| THCA (tumor) | THCA (normal) |
| GIF, CBL, CUBN (tumor) | GIF, CBL, CUBN (normal) |
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| TissGeneProg for GIF |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GIF |
| TissGeneDrug for GIF |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GIF |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1306856 | Megaloblastic anemia due to inborn errors of metabolism | 6 | BeFree |
| umls:C0002888 | Anemia, Megaloblastic | 5 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0002892 | Anemia, Pernicious | 3 | BeFree,LHGDN |
| umls:C0019196 | Hepatitis C | 3 | BeFree |
| umls:C0024523 | Malabsorption Syndrome | 3 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 3 | BeFree |
| umls:C0019163 | Hepatitis B | 2 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 2 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 2 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 2 | BeFree |
| umls:C1394891 | Intrinsic Factor Deficiency | 2 | BeFree,CLINVAR,CTD_human,UNIPROT |
| umls:C0002874 | Aplastic Anemia | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0013370 | Amebic colitis | 1 | BeFree |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0017160 | Gastroenteritis | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0022408 | Arthropathy | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | BeFree |
| umls:C0024790 | Paroxysmal nocturnal hemoglobinuria | 1 | BeFree |
| umls:C0026896 | Myasthenia Gravis | 1 | BeFree |
| umls:C0027430 | Nasal Polyps | 1 | BeFree |
| umls:C0030389 | Parainfluenza | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0033141 | Cardiomyopathies, Primary | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0036202 | Sarcoidosis | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | CTD_human |
| umls:C0040100 | Thymoma | 1 | BeFree |
| umls:C0041912 | Upper Respiratory Infections | 1 | BeFree |
| umls:C0042847 | Vitamin B 12 Deficiency | 1 | BeFree |
| umls:C0238644 | Anemia, severe | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0267446 | Acute gastroenteritis | 1 | BeFree |
| umls:C0275544 | Congenital infectious disease | 1 | BeFree |
| umls:C0278007 | Normal bowel habits | 1 | BeFree |
| umls:C0339901 | Acute respiratory infections | 1 | BeFree |
| umls:C0340068 | Aspirin-sensitive asthma with nasal polyps | 1 | BeFree |
| umls:C0340643 | Dissection of aorta | 1 | BeFree |
| umls:C0340952 | Secondary anemia NOS | 1 | BeFree |
| umls:C0340957 | Congenital deficiency of intrinsic factor | 1 | BeFree,GAD,ORPHANET |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0729233 | Dissecting aneurysm of the thoracic aorta | 1 | BeFree |
| umls:C0745287 | infertility tubal factor | 1 | BeFree |
| umls:C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | BeFree |
| umls:C0847097 | Heartburn acidity | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | GAD |
| umls:C1720983 | Channelopathies | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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