TissGeneSummary for PKD2L2 |
Gene summary |
Basic gene information | Gene symbol | PKD2L2 |
Gene name | polycystic kidney disease 2-like 2 | |
Synonyms | TRPP5 | |
Cytomap | UCSC genome browser: 5q31 | |
Type of gene | protein-coding | |
RefGenes | NM_001258448.1, NM_001258449.1,NM_001300921.1,NM_014386.3, | |
Description | polycystic kidney disease 2-like 2 proteinpolycystin-2L2polycystin-L2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604669 | |
HGNC : HGNC | ||
Ensembl : ENSG00000078795 | ||
HPRD : 05238 | ||
Vega : OTTHUMG00000163306 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PKD2L2 | |
BioGPS: 27039 | ||
Pathway | NCI Pathway Interaction Database: PKD2L2 | |
KEGG: PKD2L2 | ||
REACTOME: PKD2L2 | ||
Pathway Commons: PKD2L2 | ||
Context | iHOP: PKD2L2 | |
ligand binding site mutation search in PubMed: PKD2L2 | ||
UCL Cancer Institute: PKD2L2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PKD2L2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PKD2L2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PKD2L2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PKD2L2 |
TissGeneSNV for PKD2L2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R196Q | SKCM | 2 |
p.R118H | UCEC | 2 |
p.L192V | CESC | 2 |
p.K567R | LIHC | 1 |
p.E455K | STAD | 1 |
p.N463D | UCEC | 1 |
p.S236Y | UCEC | 1 |
p.M478K | HNSC | 1 |
p.S160P | STAD | 1 |
p.E300K | STAD | 1 |
p.F312L | COAD | 1 |
p.M478I | SKCM | 1 |
p.E573* | LUSC | 1 |
p.E395K | LUAD | 1 |
p.Y35* | SARC | 1 |
p.R196Q | READ | 1 |
p.Y19* | OV | 1 |
p.D544N | UCEC | 1 |
p.W104L | LUAD | 1 |
p.Y367* | SKCM | 1 |
p.L244I | UCS | 1 |
p.E306K | SKCM | 1 |
p.R132C | COAD | 1 |
p.Y345X | SKCM | 1 |
p.H18N | UCEC | 1 |
p.G127E | SKCM | 1 |
p.E556K | STAD | 1 |
p.Y311S | SKCM | 1 |
p.R118S | UCEC | 1 |
p.G452E | SKCM | 1 |
p.D357G | LUAD | 1 |
p.T140A | COAD | 1 |
p.L451P | LIHC | 1 |
p.G387E | SKCM | 1 |
p.E534K | READ | 1 |
p.M464I | HNSC | 1 |
p.M579I | SKCM | 1 |
p.E457D | LUAD | 1 |
p.G458S | LUSC | 1 |
p.H18R | LIHC | 1 |
p.T298A | UCEC | 1 |
p.G543R | UCEC | 1 |
p.K270M | THYM | 1 |
p.A252E | COAD | 1 |
p.E306* | UCEC | 1 |
p.E306X | READ | 1 |
p.R612L | KIRC | 1 |
p.E472D | BLCA | 1 |
p.R402C | KIRP | 1 |
p.Q461E | GBM | 1 |
p.A488T | UCEC | 1 |
p.R402H | BRCA | 1 |
p.P186T | PRAD | 1 |
p.S284F | LUSC | 1 |
p.R82H | UCEC | 1 |
p.L170F | SKCM | 1 |
p.R196Q | COAD | 1 |
p.R137S | LUAD | 1 |
p.G409E | SKCM | 1 |
p.V251A | HNSC | 1 |
p.G156S | BRCA | 1 |
p.S103* | UCEC | 1 |
p.I40R | SKCM | 1 |
p.Y585X | KIRP | 1 |
p.G127E | LUAD | 1 |
p.F78V | KIRC | 1 |
p.S477T | BLCA | 1 |
p.F281S | STAD | 1 |
p.R130T | LUAD | 1 |
p.D391Y | LGG | 1 |
p.M565I | HNSC | 1 |
p.K575M | STAD | 1 |
p.W88C | LIHC | 1 |
p.P186L | LUAD | 1 |
p.G156V | THYM | 1 |
p.S268Y | LIHC | 1 |
p.T203N | UCEC | 1 |
p.E31K | SKCM | 1 |
p.I581N | STAD | 1 |
p.T159I | ESCA | 1 |
p.D67V | DLBC | 1 |
p.V331G | KIRC | 1 |
p.R273K | UCEC | 1 |
p.R196P | SKCM | 1 |
p.S181F | PRAD | 1 |
p.S606F | SKCM | 1 |
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TissGeneCNV for PKD2L2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PKD2L2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PKD2L2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PKD2L2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PKD2L2 |
TissGeneDrug for PKD2L2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PKD2L2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |