 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for LAMP3 |
 Gene summary |
| Basic gene information | Gene symbol | LAMP3 |
| Gene name | lysosomal-associated membrane protein 3 | |
| Synonyms | CD208|DC LAMP|DC-LAMP|DCLAMP|LAMP|LAMP-3|TSC403 | |
| Cytomap | UCSC genome browser: 3q26.3-q27 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014398.3, | |
| Description | DC-lysosome-associated membrane glycoproteinlysosome-associated membrane glycoprotein 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605883 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000078081 | ||
| HPRD : 12062 | ||
| Vega : OTTHUMG00000158387 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LAMP3 | |
| BioGPS: 27074 | ||
| Pathway | NCI Pathway Interaction Database: LAMP3 | |
| KEGG: LAMP3 | ||
| REACTOME: LAMP3 | ||
| Pathway Commons: LAMP3 | ||
| Context | iHOP: LAMP3 | |
| ligand binding site mutation search in PubMed: LAMP3 | ||
| UCL Cancer Institute: LAMP3 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
| Reference showing the relevant tissue of LAMP3 | The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, Kampf C, Uhlén M, Pontén F, Micke P. FASEB J. 2014 Dec;28(12):5184-96. doi: 10.1096/fj.14-254862. Epub 2014 Aug 28. (pmid:25169055) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for LAMP3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | 1.412188826 | 0.145093911 | 1.267094915 | 1.89E-05 | 5.89E-05 |
| HNSC | 3.223976528 | 1.919367226 | 1.304609302 | 6.68E-07 | 5.27E-06 |
| LUAD | 3.881547739 | 7.17803567 | -3.296487931 | 9.25E-25 | 3.77E-23 |
| LUSC | 3.758283641 | 7.107226779 | -3.348943137 | 1.94E-22 | 3.06E-21 |
| KIRC | 0.434484377 | -1.217492012 | 1.651976389 | 1.96E-16 | 1.11E-15 |
| BLCA | 1.900024508 | -0.185780755 | 2.085805263 | 0.0105 | 0.046797595 |
| ESCA | 2.508090059 | -1.121928123 | 3.630018182 | 1.24E-05 | 0.001021393 |
| STAD | 1.735500002 | -0.462553123 | 2.198053125 | 7.21E-05 | 0.000581193 |
| KICH | 0.698211877 | -1.165584123 | 1.863796 | 0.000122 | 0.000313755 |
| Top |
| TissGene-miRNA for LAMP3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for LAMP3 |
| TissGeneSNV for LAMP3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F255S | UCEC | 1 |
| p.S411C | HNSC | 1 |
| p.S133L | STAD | 1 |
| p.Q219X | ESCA | 1 |
| p.T268M | STAD | 1 |
| p.S256L | LUAD | 1 |
| p.Q76K | BLCA | 1 |
| p.Q286X | SKCM | 1 |
| p.N280I | LUAD | 1 |
| p.P135S | COAD | 1 |
| p.K224M | LIHC | 1 |
| p.S256L | SKCM | 1 |
| p.T210M | KIRC | 1 |
| p.G157R | UCEC | 1 |
| p.Q409E | CESC | 1 |
| p.H143Y | LUAD | 1 |
| p.T268M | COAD | 1 |
| p.N93S | KIRC | 1 |
| p.R415I | UCEC | 1 |
| p.S221L | SKCM | 1 |
| p.Y36C | STAD | 1 |
| p.S133L | COAD | 1 |
| p.G213V | LUAD | 1 |
| p.K92I | SKCM | 1 |
| p.G371R | SKCM | 1 |
| p.T204I | SKCM | 1 |
| p.S173L | READ | 1 |
| p.R405C | SKCM | 1 |
| p.Q361E | BLCA | 1 |
| p.D357N | LGG | 1 |
| p.M397I | LUSC | 1 |
| p.Q286* | SKCM | 1 |
| p.A267T | PRAD | 1 |
| p.Q219* | ESCA | 1 |
| p.G213W | LUAD | 1 |
| p.S279P | LUSC | 1 |
| p.E298K | SKCM | 1 |
| p.F12L | MESO | 1 |
| p.E252K | SKCM | 1 |
| p.D47N | SKCM | 1 |
| p.V254G | STAD | 1 |
| p.V152I | LUSC | 1 |
| p.Y301H | COAD | 1 |
| p.G321R | SKCM | 1 |
| p.I48T | GBM | 1 |
| p.A325V | THYM | 1 |
| p.P218S | LGG | 1 |
| p.K224N | LUSC | 1 |
| p.I48T | OV | 1 |
| p.V105G | SKCM | 1 |
| p.V230I | OV | 1 |
| p.E299K | LGG | 1 |
| p.H72Y | SKCM | 1 |
| p.G371E | SKCM | 1 |
| p.S377* | HNSC | 1 |
| p.K354N | SKCM | 1 |
| p.Q38* | BLCA | 1 |
| p.M25T | LUAD | 1 |
| p.Q286* | HNSC | 1 |
| p.A78V | ESCA | 1 |
| Top |
| TissGeneCNV for LAMP3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for LAMP3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LGG | TCGA-FG-5963-01A | FGF12-LAMP3 | In-frame | Chr3:192444970 | Chr3:182872179 |
| Top |
| TissGeneNet for LAMP3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| LAMP3, SGTB (tumor) | LAMP3, SGTB (normal) |
 |  |
| Top |
| TissGeneProg for LAMP3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for LAMP3 |
| TissGeneDrug for LAMP3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for LAMP3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 8 | BeFree |
| umls:C0021400 | Influenza | 8 | BeFree,CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
| umls:C0011311 | Dengue Fever | 5 | BeFree |
| umls:C0005586 | Bipolar Disorder | 4 | GAD,GWASCAT |
| umls:C0042769 | Virus Diseases | 4 | BeFree |
| umls:C0041296 | Tuberculosis | 3 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 3 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0008055 | Chikungunya Fever | 2 | BeFree |
| umls:C0014057 | Japanese Encephalitis | 2 | BeFree |
| umls:C0024530 | Malaria | 2 | BeFree |
| umls:C0030567 | Parkinson Disease | 2 | BeFree,GAD |
| umls:C0034494 | Rabies (disorder) | 2 | BeFree |
| umls:C0035920 | Rubella | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1175175 | Severe Acute Respiratory Syndrome | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0007873 | Uterine Cervical Neoplasm | 1 | BeFree |
| umls:C0010246 | Coxsackievirus Infections | 1 | BeFree |
| umls:C0017160 | Gastroenteritis | 1 | BeFree |
| umls:C0017661 | IGA Glomerulonephritis | 1 | BeFree |
| umls:C0019104 | Hemorrhagic Fevers, Viral | 1 | BeFree |
| umls:C0023283 | Leishmaniasis, Cutaneous | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | LHGDN |
| umls:C0041228 | African Trypanosomiasis | 1 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0235527 | Heart Failure, Right-Sided | 1 | BeFree |
| umls:C0238286 | Mucolipidosis Type IV | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0878677 | Glycogen Storage Disease Type IIb | 1 | BeFree |
| umls:C1096903 | Sialic Acid Storage Disease, Finnish Type (disorder) | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |