TissGeneSummary for MORC1 |
Gene summary |
Basic gene information | Gene symbol | MORC1 |
Gene name | MORC family CW-type zinc finger 1 | |
Synonyms | CT33|MORC|ZCW6 | |
Cytomap | UCSC genome browser: 3q13 | |
Type of gene | protein-coding | |
RefGenes | NM_014429.3, | |
Description | MORC family CW-type zinc finger protein 1cancer/testis antigen 33microrchidia, mouse, homolog of | |
Modification date | 20141207 | |
dbXrefs | MIM : 603205 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114487 | ||
HPRD : 04439 | ||
Vega : OTTHUMG00000159209 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MORC1 | |
BioGPS: 27136 | ||
Pathway | NCI Pathway Interaction Database: MORC1 | |
KEGG: MORC1 | ||
REACTOME: MORC1 | ||
Pathway Commons: MORC1 | ||
Context | iHOP: MORC1 | |
ligand binding site mutation search in PubMed: MORC1 | ||
UCL Cancer Institute: MORC1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MORC1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MORC1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for MORC1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MORC1 |
TissGeneSNV for MORC1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E878K | SKCM | 6 |
p.E503K | SKCM | 5 |
p.P834S | SKCM | 5 |
p.E55K | SKCM | 4 |
p.R921C | SKCM | 3 |
p.D915N | SKCM | 2 |
p.M701I | SKCM | 2 |
p.E700K | SKCM | 2 |
p.E816K | SKCM | 2 |
p.Q421* | SKCM | 2 |
p.E662K | SKCM | 2 |
p.E576K | SKCM | 2 |
p.S610L | SKCM | 2 |
p.E746K | SKCM | 2 |
p.P516S | SKCM | 2 |
p.S788Y | UCEC | 1 |
p.K774I | SKCM | 1 |
p.V435F | LUAD | 1 |
p.P533Q | STAD | 1 |
p.S767N | COAD | 1 |
p.E576K | UCEC | 1 |
p.D915H | BLCA | 1 |
p.R972K | SKCM | 1 |
p.S811C | LUSC | 1 |
p.H971N | HNSC | 1 |
p.F612V | STAD | 1 |
p.S301F | SKCM | 1 |
p.P657S | SKCM | 1 |
p.A33V | LIHC | 1 |
p.N359K | LUAD | 1 |
p.E816K | SARC | 1 |
p.R14C | KIRC | 1 |
p.Q837L | LUSC | 1 |
p.E167K | SKCM | 1 |
p.V814L | SARC | 1 |
p.R234K | KIRC | 1 |
p.R89W | ACC | 1 |
p.L490I | STAD | 1 |
p.E416K | SKCM | 1 |
p.S615* | BLCA | 1 |
p.E121K | SKCM | 1 |
p.D575V | HNSC | 1 |
p.N908K | STAD | 1 |
p.N21D | COAD | 1 |
p.R85Q | UCEC | 1 |
p.S107F | SKCM | 1 |
p.V664F | LIHC | 1 |
p.N978K | SKCM | 1 |
p.Q621H | UCS | 1 |
p.E850K | SKCM | 1 |
p.W510* | SKCM | 1 |
p.W682* | LUSC | 1 |
p.A595V | PAAD | 1 |
p.R14H | SKCM | 1 |
p.K337N | READ | 1 |
p.G283E | SKCM | 1 |
p.L562Q | HNSC | 1 |
p.S497F | CESC | 1 |
p.E361K | SKCM | 1 |
p.A616V | PAAD | 1 |
p.K977N | UCEC | 1 |
p.K860T | OV | 1 |
p.S805L | LUSC | 1 |
p.D331N | SKCM | 1 |
p.K414X | LGG | 1 |
p.L495F | LUAD | 1 |
p.M108I | BRCA | 1 |
p.E983D | COAD | 1 |
p.E229K | SKCM | 1 |
p.E229K | HNSC | 1 |
p.R363Q | SKCM | 1 |
p.K863E | UCEC | 1 |
p.E527* | LUAD | 1 |
p.M864I | UCEC | 1 |
p.G384S | LGG | 1 |
p.P232Q | BLCA | 1 |
p.H19Q | LUAD | 1 |
p.S581F | SKCM | 1 |
p.R910K | SKCM | 1 |
p.S26I | LUAD | 1 |
p.V397M | HNSC | 1 |
p.A33D | THYM | 1 |
p.S797R | COAD | 1 |
p.R251K | BLCA | 1 |
p.Q674K | READ | 1 |
p.A803G | UCEC | 1 |
p.S498C | BLCA | 1 |
p.K335M | UCEC | 1 |
p.R152T | BLCA | 1 |
p.Q853R | STAD | 1 |
p.I80M | BLCA | 1 |
p.T348A | SKCM | 1 |
p.F114L | LUAD | 1 |
p.Q185K | HNSC | 1 |
p.Q186K | LUAD | 1 |
p.S670F | SKCM | 1 |
p.E607D | SKCM | 1 |
p.T123M | PAAD | 1 |
p.K918M | SKCM | 1 |
p.E553G | LUAD | 1 |
p.V52L | LUAD | 1 |
p.M166T | LUAD | 1 |
p.S734I | READ | 1 |
p.F237Y | HNSC | 1 |
p.P176L | SKCM | 1 |
p.E626K | SKCM | 1 |
p.R363Q | READ | 1 |
p.M224I | ACC | 1 |
p.V574A | HNSC | 1 |
p.W682C | LUSC | 1 |
p.L168S | COAD | 1 |
p.M379I | STAD | 1 |
p.E505* | UCEC | 1 |
p.T351M | COAD | 1 |
p.Y172F | READ | 1 |
p.A807E | LUAD | 1 |
p.R970I | UCEC | 1 |
p.S892L | SKCM | 1 |
p.E122K | BLCA | 1 |
p.E288K | BLCA | 1 |
p.G442D | ESCA | 1 |
p.R89Q | HNSC | 1 |
p.E341K | SKCM | 1 |
p.R238K | SKCM | 1 |
p.P748S | THCA | 1 |
p.Q857L | HNSC | 1 |
p.T125A | PRAD | 1 |
p.A233E | LUSC | 1 |
p.M649I | DLBC | 1 |
p.D160Y | HNSC | 1 |
p.L847S | BLCA | 1 |
p.D48V | LUAD | 1 |
p.E637Q | BRCA | 1 |
p.G209V | ESCA | 1 |
p.E300* | LUAD | 1 |
p.V324I | UCEC | 1 |
p.G84A | LUAD | 1 |
p.G620E | SKCM | 1 |
p.L927* | LUSC | 1 |
p.R446K | GBM | 1 |
p.R672T | ESCA | 1 |
p.R270I | LUAD | 1 |
p.K262I | KIRP | 1 |
p.L198M | BLCA | 1 |
p.S797N | LIHC | 1 |
p.R518S | CESC | 1 |
p.V360I | STAD | 1 |
p.C865R | UCEC | 1 |
p.R270I | UCEC | 1 |
p.D462N | SKCM | 1 |
p.P748S | SKCM | 1 |
p.E941* | UCEC | 1 |
p.E409K | SKCM | 1 |
p.K414* | LGG | 1 |
p.Q326H | PAAD | 1 |
p.E182K | SKCM | 1 |
p.T123S | OV | 1 |
p.V310G | LGG | 1 |
p.E505K | SKCM | 1 |
p.M250I | SKCM | 1 |
p.K774R | PAAD | 1 |
p.L862M | SARC | 1 |
p.D160N | SKCM | 1 |
p.E844* | UCEC | 1 |
p.G798V | LIHC | 1 |
p.F285C | UCEC | 1 |
p.E288K | SKCM | 1 |
p.D41Y | UCEC | 1 |
p.A925T | STAD | 1 |
p.S902F | SKCM | 1 |
p.L821M | LUAD | 1 |
p.Q752K | BLCA | 1 |
p.S913A | SKCM | 1 |
p.R14H | READ | 1 |
p.E637K | BLCA | 1 |
p.L116V | SKCM | 1 |
p.I625T | SKCM | 1 |
p.D3N | SKCM | 1 |
p.G226E | SKCM | 1 |
p.E688K | SKCM | 1 |
p.P771L | LUAD | 1 |
p.E953K | DLBC | 1 |
p.K753R | PAAD | 1 |
p.E607K | SKCM | 1 |
p.Q131E | LUSC | 1 |
p.V401L | BLCA | 1 |
p.A395P | LUAD | 1 |
p.A807V | UCEC | 1 |
p.M224V | UCS | 1 |
p.V761I | KIRP | 1 |
p.C452F | ESCA | 1 |
p.H588N | LUSC | 1 |
p.D113Y | UCEC | 1 |
p.Q857H | HNSC | 1 |
p.P686Q | BRCA | 1 |
p.P834L | SKCM | 1 |
p.E637K | SKCM | 1 |
p.W773* | SKCM | 1 |
p.V397M | UCEC | 1 |
p.Q326P | HNSC | 1 |
p.G195D | HNSC | 1 |
p.K930E | STAD | 1 |
p.S913C | BLCA | 1 |
p.Q432P | LUSC | 1 |
p.G479V | UCEC | 1 |
p.D230N | SKCM | 1 |
p.E576K | BLCA | 1 |
p.S242T | HNSC | 1 |
p.D113Y | READ | 1 |
p.A697T | UCEC | 1 |
p.K596I | BLCA | 1 |
p.L405V | UCEC | 1 |
p.G689R | SKCM | 1 |
p.E983K | SKCM | 1 |
p.E941K | UCEC | 1 |
p.P211A | LUAD | 1 |
p.A792D | CESC | 1 |
p.S644A | BRCA | 1 |
p.E668K | SKCM | 1 |
p.G192R | SKCM | 1 |
p.M108I | UCEC | 1 |
p.C854R | SKCM | 1 |
p.A20T | ESCA | 1 |
p.K178T | COAD | 1 |
p.E743K | SKCM | 1 |
p.R350S | ESCA | 1 |
p.W149* | SKCM | 1 |
p.H412Y | HNSC | 1 |
p.E341* | GBM | 1 |
p.R258I | UCEC | 1 |
p.R89Q | PRAD | 1 |
p.L777H | GBM | 1 |
p.N984Y | SKCM | 1 |
p.M408T | LUAD | 1 |
p.S242A | LGG | 1 |
p.R972I | PRAD | 1 |
p.D67N | SKCM | 1 |
p.G97A | BRCA | 1 |
p.R89W | BRCA | 1 |
p.L213F | BRCA | 1 |
p.R618C | GBM | 1 |
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TissGeneCNV for MORC1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MORC1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | OV | TCGA-09-2044-01B | SPICE1-MORC1 | In-frame | Chr3:113207792 | Chr3:108690249 |
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TissGeneNet for MORC1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MORC1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MORC1 |
TissGeneDrug for MORC1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MORC1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0038443 | Stress, Psychological | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0041696 | Unipolar Depression | 1 | BeFree |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree |