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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CPAMD8
check button Gene summary
Basic gene informationGene symbolCPAMD8
Gene nameC3 and PZP-like, alpha-2-macroglobulin domain containing 8
SynonymsK-CAP|VIP
CytomapUCSC genome browser: 19p13.11
Type of geneprotein-coding
RefGenesNM_015692.2,
DescriptionC3 and PZP-like alpha-2-macroglobulin domain-containing protein 8alpha-2 macroglobulin family protein VIP
Modification date20141207
dbXrefs MIM : 608841
HGNC : HGNC
Ensembl : ENSG00000160111
HPRD : 09892
Vega : OTTHUMG00000133549
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CPAMD8
BioGPS: 27151
PathwayNCI Pathway Interaction Database: CPAMD8
KEGG: CPAMD8
REACTOME: CPAMD8
Pathway Commons: CPAMD8
ContextiHOP: CPAMD8
ligand binding site mutation search in PubMed: CPAMD8
UCL Cancer Institute: CPAMD8
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ProstateEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRADUVM
Reference showing the relevant tissue of CPAMD8
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CPAMD8

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD2.6945061093.935477263-1.2409711543.41E-106.32E-09
KIRC-0.4980957072.785314015-3.2834097221.36E-416.10E-40
COAD-2.697995814-1.179518891-1.5184769236.54E-084.79E-07
LUSC-0.4238451353.50529212-3.9291372553.91E-194.11E-18
KICH-0.8215524293.135323571-3.9568761.12E-163.63E-15
KIRP-0.9769273042.808328946-3.785256251.38E-111.86E-10
LUAD0.8673143983.610133364-2.7428189661.27E-161.52E-15
BRCA-0.2918663941.919599395-2.2114657891.25E-251.29E-24


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TissGene-miRNA for CPAMD8

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CPAMD8
TissGeneSNV for CPAMD8

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R568CSKCM7
p.R449GPAAD4
p.P1721RBRCA3
p.S523YPCPG2
p.R1164QSKCM2
p.A1351VPCPG2
p.P779SSKCM2
p.R973CUCEC2
p.S523YUVM2
p.R1389QSKCM2
p.D969NSKCM1
p.V611ISTAD1
p.R89CSKCM1
p.N1104SOV1
p.E1425KHNSC1
p.M1536ILIHC1
p.R1221TBLCA1
p.P783HDLBC1
p.Y271CKIRC1
p.A1282VUCEC1
p.R1656*HNSC1
p.W300*UCEC1
p.R1019CSTAD1
p.G941ESKCM1
p.P779SUCEC1
p.S1686LSTAD1
p.D942NUCEC1
p.Q623*CESC1
p.L1436RSTAD1
p.G1827RGBM1
p.G1818ESKCM1
p.R555QUCEC1
p.R173WUCEC1
p.G481ESKCM1
p.E1841QBLCA1
p.F1274LSKCM1
p.V897DBRCA1
p.V1048IGBM1
p.V410MSTAD1
p.D586EREAD1
p.V611IBLCA1
p.E208KSTAD1
p.P1116SUCEC1
p.V1322MLUAD1
p.G328RSKCM1
p.V1446LBRCA1
p.V982ISKCM1
p.D690NCESC1
p.T427MSTAD1
p.D419NSKCM1
p.T551SSKCM1
p.E702KSKCM1
p.A1299VSARC1
p.S396FSKCM1
p.V199IHNSC1
p.P1114LLIHC1
p.R715*STAD1
p.E516DSKCM1
p.P983SSKCM1
p.P457SHNSC1
p.Q1890RCOAD1
p.P1160SSKCM1
p.M886IREAD1
p.V911LLUAD1
p.P1117TSKCM1
p.M886ISKCM1
p.R1016SHNSC1
p.A1593VCOAD1
p.W1583CLUSC1
p.V977AREAD1
p.R1164*PAAD1
p.G1171ESKCM1
p.A496TSKCM1
p.D1642AKIRC1
p.V905LLUAD1
p.Q768*LUAD1
p.R984LLUSC1
p.E357QLUAD1
p.R568CSTAD1
p.G1391RSKCM1
p.R1655HPAAD1
p.A1030VUCEC1
p.P205LLUSC1
p.R715XSTAD1
p.E1622QBLCA1
p.N641HLUSC1
p.G453VLUAD1
p.A560DESCA1
p.G219VESCA1
p.Q754RLUAD1
p.S144*BRCA1
p.V199ISKCM1
p.G1051RSKCM1
p.K275TBLCA1
p.R1135QSKCM1
p.H593YSKCM1
p.R191QLGG1
p.E796KSKCM1
p.R1019HLUAD1
p.T198ISKCM1
p.S635LSKCM1
p.E1081KSKCM1
p.V922ILUAD1
p.R605HSTAD1
p.R568HSKCM1
p.L1215IUCEC1
p.E93DPAAD1
p.W1583*CESC1
p.W150CCOAD1
p.S1243FUCEC1
p.S1125FSKCM1
p.C1360FLUSC1
p.P1826LSTAD1
p.S340FUCEC1
p.E491KSKCM1
p.D1307NSKCM1
p.M222RSKCM1
p.R1164QESCA1
p.R1270CSTAD1
p.R903CSTAD1
p.R1239HCOAD1
p.S924FSKCM1
p.S1036TBRCA1
p.A595TCOAD1
p.E326QHNSC1
p.V513_spliceOV1
p.G374WESCA1
p.C946WLUAD1
p.A111DSARC1
p.R718LLUAD1
p.E631KUCEC1
p.Y213COV1
p.Y671CKIRP1
p.Y1650CPAAD1
p.R1580QUCEC1
p.I805MPRAD1
p.G1310SSKCM1
p.R341QCOAD1
p.L603FSKCM1
p.V1557ISTAD1
p.M1426ISKCM1
p.T570SLUSC1
p.V601LHNSC1
p.Y495FLUAD1
p.A960THNSC1
p.L592FSKCM1
p.G646WLUAD1
p.T1407ILGG1
p.G539DLUAD1
p.D419YHNSC1
p.H801YSTAD1
p.P913SHNSC1
p.C527YUCEC1
p.R791KSKCM1
p.R1454QLGG1
p.D381NUCS1
p.S1333LCESC1
p.T760NPRAD1
p.V199ILGG1
p.V1262LSTAD1
p.S591ALUSC1
p.G514WLUAD1
p.R568CBLCA1
p.R89HSTAD1
p.C500XLIHC1
p.D695HUCEC1
p.Q1012LLIHC1
p.Q1009RHNSC1
p.R1371HGBM1
p.Y1146HSKCM1
p.V477ILGG1
p.A1074TSKCM1
p.R568CUCEC1
p.E1148KCESC1
p.R715QUCEC1
p.A261THNSC1
p.S520YSTAD1
p.D586ECOAD1
p.P526LSTAD1
p.T1151ISKCM1
p.R1083TBRCA1
p.A1492TSTAD1
p.P602TESCA1
p.X1933EKIRC1
p.D182NSKCM1
p.P1902LCOAD1
p.M886VLUAD1
p.V596MHNSC1
p.E613KSKCM1
p.G1099SDLBC1
p.A423TSKCM1
p.P1114LSTAD1
p.D620NCOAD1
p.T1315ICOAD1
p.D755GUCEC1
p.A90EUCEC1
p.V1440MPRAD1
p.R191*UCEC1
p.G539DLIHC1
p.T739MSTAD1
p.R1383CHNSC1
p.P418LSKCM1
p.D1294NSKCM1
p.H959DBLCA1
p.G1406SSKCM1
p.R298WDLBC1
p.Y1146CHNSC1
p.P1518SSKCM1
p.R753WLGG1
p.A1375SKIRC1
p.A682SBLCA1
p.V1623LLUSC1
p.V922IPAAD1
p.G1523RSKCM1
p.R191QSKCM1
p.P705SSKCM1
p.W150XSKCM1
p.E515KSKCM1
p.Q623*SKCM1
p.R1186WSARC1
p.R753QSKCM1
p.D620NSTAD1
p.R1580QLGG1
p.L1432PBRCA1
p.D1594NSKCM1
p.N932SSKCM1
p.Y691DLIHC1
p.R1895WUCEC1
p.D1855ETHYM1
p.A985TSKCM1
p.S520FSKCM1
p.D1531NSKCM1
p.T1061NKIRC1
p.F252LSKCM1
p.H959QESCA1
p.P900SSKCM1
p.G981RSKCM1
p.W150*SKCM1
p.Q754XDLBC1
p.S639LSARC1
p.T1259ILUAD1
p.S1419FBRCA1
p.P1847HPRAD1
p.R1270HCHOL1
p.S65LSTAD1
p.A1167TSTAD1
p.P1317SSKCM1
p.A1351VCOAD1
p.V185LPRAD1
p.P723LSTAD1
p.G772ESKCM1
p.G1566RSKCM1
p.R678WHNSC1
p.A1351VBRCA1
p.S1519ILUAD1
p.E584KSKCM1
p.V1173ISTAD1
p.L1658FSTAD1
p.K1139ESARC1
p.L491FSKCM1
p.G981ESKCM1
p.N1305SUVM1
p.A1256VBRCA1
p.V1511ASTAD1
p.D349NSKCM1
p.G1581ESKCM1
p.A1267TPAAD1


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TissGeneCNV for CPAMD8

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CPAMD8

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanPRADTCGA-YJ-A8SW-01AEPS15L1-CPAMD8In-Framechr19:16582723chr19:17049256
TCGAfusionPortalPRADABRCATCGA-AO-A1KR-01ACPAMD8-HAUS8Out-of-frameChr19:17085907Chr19:17160986
TCGAfusionPortalPRADAOVTCGA-13-0768-01ACHERP-CPAMD8Out-of-frameChr19:16652681Chr19:17017927


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TissGeneNet for CPAMD8

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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COAD (tumor)COAD (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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HNSC (tumor)HNSC (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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KICH (tumor)KICH (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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KIRC (tumor)KIRC (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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KIRP (tumor)KIRP (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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LIHC (tumor)LIHC (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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LUAD (tumor)LUAD (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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LUSC (tumor)LUSC (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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PRAD (tumor)PRAD (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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STAD (tumor)STAD (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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THCA (tumor)THCA (normal)
CPAMD8, DPP4, ADCYAP1, SCTR (tumor)CPAMD8, DPP4, ADCYAP1, SCTR (normal)
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TissGeneProg for CPAMD8

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CPAMD8
TissGeneDrug for CPAMD8

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CPAMD8

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027819Neuroblastoma7BeFree
umls:C0700095Central neuroblastoma7BeFree
umls:C0003873Rheumatoid Arthritis5BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0009319Colitis2BeFree
umls:C0026769Multiple Sclerosis2BeFree,GAD
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0009404Colorectal Neoplasms1CTD_human
umls:C0010692Cystitis1BeFree
umls:C0011884Diabetic Retinopathy1BeFree
umls:C0021841Intestinal Neoplasms1BeFree
umls:C0022104Irritable Bowel Syndrome1BeFree
umls:C0032002Pituitary Diseases1BeFree
umls:C0085580Essential Hypertension1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0747845early pregnancy1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C3203102Idiopathic pulmonary arterial hypertension1BeFree