TissGeneSummary for CPAMD8 |
Gene summary |
Basic gene information | Gene symbol | CPAMD8 |
Gene name | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | |
Synonyms | K-CAP|VIP | |
Cytomap | UCSC genome browser: 19p13.11 | |
Type of gene | protein-coding | |
RefGenes | NM_015692.2, | |
Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8alpha-2 macroglobulin family protein VIP | |
Modification date | 20141207 | |
dbXrefs | MIM : 608841 | |
HGNC : HGNC | ||
Ensembl : ENSG00000160111 | ||
HPRD : 09892 | ||
Vega : OTTHUMG00000133549 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CPAMD8 | |
BioGPS: 27151 | ||
Pathway | NCI Pathway Interaction Database: CPAMD8 | |
KEGG: CPAMD8 | ||
REACTOME: CPAMD8 | ||
Pathway Commons: CPAMD8 | ||
Context | iHOP: CPAMD8 | |
ligand binding site mutation search in PubMed: CPAMD8 | ||
UCL Cancer Institute: CPAMD8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADUVM | |
Reference showing the relevant tissue of CPAMD8 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CPAMD8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 2.694506109 | 3.935477263 | -1.240971154 | 3.41E-10 | 6.32E-09 |
KIRC | -0.498095707 | 2.785314015 | -3.283409722 | 1.36E-41 | 6.10E-40 |
COAD | -2.697995814 | -1.179518891 | -1.518476923 | 6.54E-08 | 4.79E-07 |
LUSC | -0.423845135 | 3.50529212 | -3.929137255 | 3.91E-19 | 4.11E-18 |
KICH | -0.821552429 | 3.135323571 | -3.956876 | 1.12E-16 | 3.63E-15 |
KIRP | -0.976927304 | 2.808328946 | -3.78525625 | 1.38E-11 | 1.86E-10 |
LUAD | 0.867314398 | 3.610133364 | -2.742818966 | 1.27E-16 | 1.52E-15 |
BRCA | -0.291866394 | 1.919599395 | -2.211465789 | 1.25E-25 | 1.29E-24 |
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TissGene-miRNA for CPAMD8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CPAMD8 |
TissGeneSNV for CPAMD8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R568C | SKCM | 7 |
p.R449G | PAAD | 4 |
p.P1721R | BRCA | 3 |
p.S523Y | PCPG | 2 |
p.R1164Q | SKCM | 2 |
p.A1351V | PCPG | 2 |
p.P779S | SKCM | 2 |
p.R973C | UCEC | 2 |
p.S523Y | UVM | 2 |
p.R1389Q | SKCM | 2 |
p.D969N | SKCM | 1 |
p.V611I | STAD | 1 |
p.R89C | SKCM | 1 |
p.N1104S | OV | 1 |
p.E1425K | HNSC | 1 |
p.M1536I | LIHC | 1 |
p.R1221T | BLCA | 1 |
p.P783H | DLBC | 1 |
p.Y271C | KIRC | 1 |
p.A1282V | UCEC | 1 |
p.R1656* | HNSC | 1 |
p.W300* | UCEC | 1 |
p.R1019C | STAD | 1 |
p.G941E | SKCM | 1 |
p.P779S | UCEC | 1 |
p.S1686L | STAD | 1 |
p.D942N | UCEC | 1 |
p.Q623* | CESC | 1 |
p.L1436R | STAD | 1 |
p.G1827R | GBM | 1 |
p.G1818E | SKCM | 1 |
p.R555Q | UCEC | 1 |
p.R173W | UCEC | 1 |
p.G481E | SKCM | 1 |
p.E1841Q | BLCA | 1 |
p.F1274L | SKCM | 1 |
p.V897D | BRCA | 1 |
p.V1048I | GBM | 1 |
p.V410M | STAD | 1 |
p.D586E | READ | 1 |
p.V611I | BLCA | 1 |
p.E208K | STAD | 1 |
p.P1116S | UCEC | 1 |
p.V1322M | LUAD | 1 |
p.G328R | SKCM | 1 |
p.V1446L | BRCA | 1 |
p.V982I | SKCM | 1 |
p.D690N | CESC | 1 |
p.T427M | STAD | 1 |
p.D419N | SKCM | 1 |
p.T551S | SKCM | 1 |
p.E702K | SKCM | 1 |
p.A1299V | SARC | 1 |
p.S396F | SKCM | 1 |
p.V199I | HNSC | 1 |
p.P1114L | LIHC | 1 |
p.R715* | STAD | 1 |
p.E516D | SKCM | 1 |
p.P983S | SKCM | 1 |
p.P457S | HNSC | 1 |
p.Q1890R | COAD | 1 |
p.P1160S | SKCM | 1 |
p.M886I | READ | 1 |
p.V911L | LUAD | 1 |
p.P1117T | SKCM | 1 |
p.M886I | SKCM | 1 |
p.R1016S | HNSC | 1 |
p.A1593V | COAD | 1 |
p.W1583C | LUSC | 1 |
p.V977A | READ | 1 |
p.R1164* | PAAD | 1 |
p.G1171E | SKCM | 1 |
p.A496T | SKCM | 1 |
p.D1642A | KIRC | 1 |
p.V905L | LUAD | 1 |
p.Q768* | LUAD | 1 |
p.R984L | LUSC | 1 |
p.E357Q | LUAD | 1 |
p.R568C | STAD | 1 |
p.G1391R | SKCM | 1 |
p.R1655H | PAAD | 1 |
p.A1030V | UCEC | 1 |
p.P205L | LUSC | 1 |
p.R715X | STAD | 1 |
p.E1622Q | BLCA | 1 |
p.N641H | LUSC | 1 |
p.G453V | LUAD | 1 |
p.A560D | ESCA | 1 |
p.G219V | ESCA | 1 |
p.Q754R | LUAD | 1 |
p.S144* | BRCA | 1 |
p.V199I | SKCM | 1 |
p.G1051R | SKCM | 1 |
p.K275T | BLCA | 1 |
p.R1135Q | SKCM | 1 |
p.H593Y | SKCM | 1 |
p.R191Q | LGG | 1 |
p.E796K | SKCM | 1 |
p.R1019H | LUAD | 1 |
p.T198I | SKCM | 1 |
p.S635L | SKCM | 1 |
p.E1081K | SKCM | 1 |
p.V922I | LUAD | 1 |
p.R605H | STAD | 1 |
p.R568H | SKCM | 1 |
p.L1215I | UCEC | 1 |
p.E93D | PAAD | 1 |
p.W1583* | CESC | 1 |
p.W150C | COAD | 1 |
p.S1243F | UCEC | 1 |
p.S1125F | SKCM | 1 |
p.C1360F | LUSC | 1 |
p.P1826L | STAD | 1 |
p.S340F | UCEC | 1 |
p.E491K | SKCM | 1 |
p.D1307N | SKCM | 1 |
p.M222R | SKCM | 1 |
p.R1164Q | ESCA | 1 |
p.R1270C | STAD | 1 |
p.R903C | STAD | 1 |
p.R1239H | COAD | 1 |
p.S924F | SKCM | 1 |
p.S1036T | BRCA | 1 |
p.A595T | COAD | 1 |
p.E326Q | HNSC | 1 |
p.V513_splice | OV | 1 |
p.G374W | ESCA | 1 |
p.C946W | LUAD | 1 |
p.A111D | SARC | 1 |
p.R718L | LUAD | 1 |
p.E631K | UCEC | 1 |
p.Y213C | OV | 1 |
p.Y671C | KIRP | 1 |
p.Y1650C | PAAD | 1 |
p.R1580Q | UCEC | 1 |
p.I805M | PRAD | 1 |
p.G1310S | SKCM | 1 |
p.R341Q | COAD | 1 |
p.L603F | SKCM | 1 |
p.V1557I | STAD | 1 |
p.M1426I | SKCM | 1 |
p.T570S | LUSC | 1 |
p.V601L | HNSC | 1 |
p.Y495F | LUAD | 1 |
p.A960T | HNSC | 1 |
p.L592F | SKCM | 1 |
p.G646W | LUAD | 1 |
p.T1407I | LGG | 1 |
p.G539D | LUAD | 1 |
p.D419Y | HNSC | 1 |
p.H801Y | STAD | 1 |
p.P913S | HNSC | 1 |
p.C527Y | UCEC | 1 |
p.R791K | SKCM | 1 |
p.R1454Q | LGG | 1 |
p.D381N | UCS | 1 |
p.S1333L | CESC | 1 |
p.T760N | PRAD | 1 |
p.V199I | LGG | 1 |
p.V1262L | STAD | 1 |
p.S591A | LUSC | 1 |
p.G514W | LUAD | 1 |
p.R568C | BLCA | 1 |
p.R89H | STAD | 1 |
p.C500X | LIHC | 1 |
p.D695H | UCEC | 1 |
p.Q1012L | LIHC | 1 |
p.Q1009R | HNSC | 1 |
p.R1371H | GBM | 1 |
p.Y1146H | SKCM | 1 |
p.V477I | LGG | 1 |
p.A1074T | SKCM | 1 |
p.R568C | UCEC | 1 |
p.E1148K | CESC | 1 |
p.R715Q | UCEC | 1 |
p.A261T | HNSC | 1 |
p.S520Y | STAD | 1 |
p.D586E | COAD | 1 |
p.P526L | STAD | 1 |
p.T1151I | SKCM | 1 |
p.R1083T | BRCA | 1 |
p.A1492T | STAD | 1 |
p.P602T | ESCA | 1 |
p.X1933E | KIRC | 1 |
p.D182N | SKCM | 1 |
p.P1902L | COAD | 1 |
p.M886V | LUAD | 1 |
p.V596M | HNSC | 1 |
p.E613K | SKCM | 1 |
p.G1099S | DLBC | 1 |
p.A423T | SKCM | 1 |
p.P1114L | STAD | 1 |
p.D620N | COAD | 1 |
p.T1315I | COAD | 1 |
p.D755G | UCEC | 1 |
p.A90E | UCEC | 1 |
p.V1440M | PRAD | 1 |
p.R191* | UCEC | 1 |
p.G539D | LIHC | 1 |
p.T739M | STAD | 1 |
p.R1383C | HNSC | 1 |
p.P418L | SKCM | 1 |
p.D1294N | SKCM | 1 |
p.H959D | BLCA | 1 |
p.G1406S | SKCM | 1 |
p.R298W | DLBC | 1 |
p.Y1146C | HNSC | 1 |
p.P1518S | SKCM | 1 |
p.R753W | LGG | 1 |
p.A1375S | KIRC | 1 |
p.A682S | BLCA | 1 |
p.V1623L | LUSC | 1 |
p.V922I | PAAD | 1 |
p.G1523R | SKCM | 1 |
p.R191Q | SKCM | 1 |
p.P705S | SKCM | 1 |
p.W150X | SKCM | 1 |
p.E515K | SKCM | 1 |
p.Q623* | SKCM | 1 |
p.R1186W | SARC | 1 |
p.R753Q | SKCM | 1 |
p.D620N | STAD | 1 |
p.R1580Q | LGG | 1 |
p.L1432P | BRCA | 1 |
p.D1594N | SKCM | 1 |
p.N932S | SKCM | 1 |
p.Y691D | LIHC | 1 |
p.R1895W | UCEC | 1 |
p.D1855E | THYM | 1 |
p.A985T | SKCM | 1 |
p.S520F | SKCM | 1 |
p.D1531N | SKCM | 1 |
p.T1061N | KIRC | 1 |
p.F252L | SKCM | 1 |
p.H959Q | ESCA | 1 |
p.P900S | SKCM | 1 |
p.G981R | SKCM | 1 |
p.W150* | SKCM | 1 |
p.Q754X | DLBC | 1 |
p.S639L | SARC | 1 |
p.T1259I | LUAD | 1 |
p.S1419F | BRCA | 1 |
p.P1847H | PRAD | 1 |
p.R1270H | CHOL | 1 |
p.S65L | STAD | 1 |
p.A1167T | STAD | 1 |
p.P1317S | SKCM | 1 |
p.A1351V | COAD | 1 |
p.V185L | PRAD | 1 |
p.P723L | STAD | 1 |
p.G772E | SKCM | 1 |
p.G1566R | SKCM | 1 |
p.R678W | HNSC | 1 |
p.A1351V | BRCA | 1 |
p.S1519I | LUAD | 1 |
p.E584K | SKCM | 1 |
p.V1173I | STAD | 1 |
p.L1658F | STAD | 1 |
p.K1139E | SARC | 1 |
p.L491F | SKCM | 1 |
p.G981E | SKCM | 1 |
p.N1305S | UVM | 1 |
p.A1256V | BRCA | 1 |
p.V1511A | STAD | 1 |
p.D349N | SKCM | 1 |
p.G1581E | SKCM | 1 |
p.A1267T | PAAD | 1 |
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TissGeneCNV for CPAMD8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CPAMD8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-YJ-A8SW-01A | EPS15L1-CPAMD8 | In-Frame | chr19:16582723 | chr19:17049256 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A1KR-01A | CPAMD8-HAUS8 | Out-of-frame | Chr19:17085907 | Chr19:17160986 |
TCGAfusionPortal | PRADA | OV | TCGA-13-0768-01A | CHERP-CPAMD8 | Out-of-frame | Chr19:16652681 | Chr19:17017927 |
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TissGeneNet for CPAMD8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CPAMD8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CPAMD8 |
TissGeneDrug for CPAMD8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CPAMD8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027819 | Neuroblastoma | 7 | BeFree |
umls:C0700095 | Central neuroblastoma | 7 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 5 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
umls:C0600139 | Prostate carcinoma | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0009319 | Colitis | 2 | BeFree |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree,GAD |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0007570 | Celiac Disease | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |
umls:C0010692 | Cystitis | 1 | BeFree |
umls:C0011884 | Diabetic Retinopathy | 1 | BeFree |
umls:C0021841 | Intestinal Neoplasms | 1 | BeFree |
umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree |
umls:C0032002 | Pituitary Diseases | 1 | BeFree |
umls:C0085580 | Essential Hypertension | 1 | BeFree |
umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
umls:C0747845 | early pregnancy | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |
umls:C1654637 | androgen independent prostate cancer | 1 | BeFree |
umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
umls:C3203102 | Idiopathic pulmonary arterial hypertension | 1 | BeFree |