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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for IL37
check button Gene summary
Basic gene informationGene symbolIL37
Gene nameinterleukin 37
SynonymsFIL1|FIL1(ZETA)|FIL1Z|IL-1F7|IL-1H|IL-1H4|IL-1RP1|IL-37|IL1F7|IL1H4|IL1RP1
CytomapUCSC genome browser: 2q12-q14.1
Type of geneprotein-coding
RefGenesNM_014439.3,
NM_173202.1,NM_173203.1,NM_173204.1,NM_173205.1,
DescriptionFIL1 zetaIL-1 zetaIL-1F7b (IL-1H4, IL-1H, IL-1RP1)IL-1X proteinIL1F7 (canonical product IL-1F7b)interleukin 1 family member 7interleukin 1, zetainterleukin-1 homolog 4interleukin-1 superfamily zinterleukin-1-related proteininterleukin-23interle
Modification date20141222
dbXrefs MIM : 605510
HGNC : HGNC
Ensembl : ENSG00000125571
HPRD : 05695
Vega : OTTHUMG00000131345
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL37
BioGPS: 27178
PathwayNCI Pathway Interaction Database: IL37
KEGG: IL37
REACTOME: IL37
Pathway Commons: IL37
ContextiHOP: IL37
ligand binding site mutation search in PubMed: IL37
UCL Cancer Institute: IL37
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Skin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)SKCM
Reference showing the relevant tissue of IL37
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for IL37

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for IL37

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for IL37
TissGeneSNV for IL37

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S202LSKCM7
p.S176LSKCM4
p.E18KSKCM2
p.R22TBLCA1
p.C178YHNSC1
p.G37DACC1
p.D191YBLCA1
p.E215KCESC1
p.D66VSKCM1
p.P105SSKCM1
p.F118LUCEC1
p.G174RUCEC1
p.S132FSKCM1
p.G80ESKCM1
p.V52MSKCM1
p.S106FSKCM1
p.N195KLUAD1
p.E185KSKCM1
p.G188VTHYM1
p.S97FSKCM1
p.T42NLUAD1
p.S169LSTAD1
p.P82LCOAD1
p.S39RLUAD1
p.E148GLUSC1
p.E200*LUAD1
p.R151CBLCA1
p.P22LESCA1
p.E148KSKCM1
p.D20NCESC1
p.W17*SKCM1
p.E210KBLCA1
p.G106ESKCM1
p.G116RSKCM1
p.W164*BLCA1
p.P131SSKCM1
p.L120FSKCM1
p.D123HHNSC1
p.L94FSKCM1
p.R87CDLBC1
p.G116WSKCM1
p.R158KLUAD1
p.G112RSKCM1


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TissGeneCNV for IL37

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for IL37

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for IL37

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for IL37

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.

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TissGeneClin for IL37
TissGeneDrug for IL37

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for IL37

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0038013Ankylosing spondylitis9BeFree,GAD
umls:C0004364Autoimmune Diseases6BeFree
umls:C0021390Inflammatory Bowel Diseases6BeFree
umls:C0033860Psoriasis6BeFree
umls:C0003873Rheumatoid Arthritis5BeFree,GAD
umls:C0009324Ulcerative Colitis5BeFree
umls:C0024141Lupus Erythematosus, Systemic5BeFree
umls:C1290884Inflammatory disorder3BeFree
umls:C0004943Behcet Syndrome2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0011615Dermatitis, Atopic2BeFree
umls:C0013595Eczema2BeFree
umls:C0949690Spondylarthritis2BeFree
umls:C0004096Asthma1BeFree
umls:C0004623Bacterial Infections1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0011616Contact Dermatitis1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0014743Erythema Nodosum1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0023860Listeriosis1BeFree
umls:C0024198Lyme Disease1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0028754Obesity1BeFree
umls:C0029456Osteoporosis1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0042164Uveitis1BeFree
umls:C0042170Uveomeningoencephalitic Syndrome1BeFree
umls:C0085669Acute leukemia1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0238067Colitis, Collagenous1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0263361Psoriasis vulgaris1BeFree
umls:C0264408Childhood asthma1BeFree
umls:C0279584B-cell childhood acute lymphoblastic leukemia1BeFree
umls:C0376545Hematologic Neoplasms1BeFree
umls:C0400822Colitis, Lymphocytic1BeFree
umls:C0409980Primary antiphospholipid syndrome1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0949691Spondylarthropathies1BeFree
umls:C0971858Arthritis, Collagen-Induced1BeFree
umls:C0993582Arthritis, Experimental1BeFree
umls:C2239176Liver carcinoma1BeFree