TissGeneSummary for IL37 |
Gene summary |
Basic gene information | Gene symbol | IL37 |
Gene name | interleukin 37 | |
Synonyms | FIL1|FIL1(ZETA)|FIL1Z|IL-1F7|IL-1H|IL-1H4|IL-1RP1|IL-37|IL1F7|IL1H4|IL1RP1 | |
Cytomap | UCSC genome browser: 2q12-q14.1 | |
Type of gene | protein-coding | |
RefGenes | NM_014439.3, NM_173202.1,NM_173203.1,NM_173204.1,NM_173205.1, | |
Description | FIL1 zetaIL-1 zetaIL-1F7b (IL-1H4, IL-1H, IL-1RP1)IL-1X proteinIL1F7 (canonical product IL-1F7b)interleukin 1 family member 7interleukin 1, zetainterleukin-1 homolog 4interleukin-1 superfamily zinterleukin-1-related proteininterleukin-23interle | |
Modification date | 20141222 | |
dbXrefs | MIM : 605510 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125571 | ||
HPRD : 05695 | ||
Vega : OTTHUMG00000131345 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL37 | |
BioGPS: 27178 | ||
Pathway | NCI Pathway Interaction Database: IL37 | |
KEGG: IL37 | ||
REACTOME: IL37 | ||
Pathway Commons: IL37 | ||
Context | iHOP: IL37 | |
ligand binding site mutation search in PubMed: IL37 | ||
UCL Cancer Institute: IL37 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of IL37 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IL37 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for IL37 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IL37 |
TissGeneSNV for IL37 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S202L | SKCM | 7 |
p.S176L | SKCM | 4 |
p.E18K | SKCM | 2 |
p.R22T | BLCA | 1 |
p.C178Y | HNSC | 1 |
p.G37D | ACC | 1 |
p.D191Y | BLCA | 1 |
p.E215K | CESC | 1 |
p.D66V | SKCM | 1 |
p.P105S | SKCM | 1 |
p.F118L | UCEC | 1 |
p.G174R | UCEC | 1 |
p.S132F | SKCM | 1 |
p.G80E | SKCM | 1 |
p.V52M | SKCM | 1 |
p.S106F | SKCM | 1 |
p.N195K | LUAD | 1 |
p.E185K | SKCM | 1 |
p.G188V | THYM | 1 |
p.S97F | SKCM | 1 |
p.T42N | LUAD | 1 |
p.S169L | STAD | 1 |
p.P82L | COAD | 1 |
p.S39R | LUAD | 1 |
p.E148G | LUSC | 1 |
p.E200* | LUAD | 1 |
p.R151C | BLCA | 1 |
p.P22L | ESCA | 1 |
p.E148K | SKCM | 1 |
p.D20N | CESC | 1 |
p.W17* | SKCM | 1 |
p.E210K | BLCA | 1 |
p.G106E | SKCM | 1 |
p.G116R | SKCM | 1 |
p.W164* | BLCA | 1 |
p.P131S | SKCM | 1 |
p.L120F | SKCM | 1 |
p.D123H | HNSC | 1 |
p.L94F | SKCM | 1 |
p.R87C | DLBC | 1 |
p.G116W | SKCM | 1 |
p.R158K | LUAD | 1 |
p.G112R | SKCM | 1 |
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TissGeneCNV for IL37 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IL37 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for IL37 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IL37 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IL37 |
TissGeneDrug for IL37 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IL37 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0038013 | Ankylosing spondylitis | 9 | BeFree,GAD |
umls:C0004364 | Autoimmune Diseases | 6 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 6 | BeFree |
umls:C0033860 | Psoriasis | 6 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 5 | BeFree,GAD |
umls:C0009324 | Ulcerative Colitis | 5 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 5 | BeFree |
umls:C1290884 | Inflammatory disorder | 3 | BeFree |
umls:C0004943 | Behcet Syndrome | 2 | BeFree |
umls:C0010346 | Crohn Disease | 2 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 2 | BeFree |
umls:C0013595 | Eczema | 2 | BeFree |
umls:C0949690 | Spondylarthritis | 2 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0004623 | Bacterial Infections | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0011616 | Contact Dermatitis | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0014743 | Erythema Nodosum | 1 | BeFree |
umls:C0018213 | Graves Disease | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | BeFree |
umls:C0023860 | Listeriosis | 1 | BeFree |
umls:C0024198 | Lyme Disease | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0029456 | Osteoporosis | 1 | BeFree |
umls:C0041296 | Tuberculosis | 1 | BeFree |
umls:C0042164 | Uveitis | 1 | BeFree |
umls:C0042170 | Uveomeningoencephalitic Syndrome | 1 | BeFree |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0238067 | Colitis, Collagenous | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0263361 | Psoriasis vulgaris | 1 | BeFree |
umls:C0264408 | Childhood asthma | 1 | BeFree |
umls:C0279584 | B-cell childhood acute lymphoblastic leukemia | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
umls:C0400822 | Colitis, Lymphocytic | 1 | BeFree |
umls:C0409980 | Primary antiphospholipid syndrome | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0949691 | Spondylarthropathies | 1 | BeFree |
umls:C0971858 | Arthritis, Collagen-Induced | 1 | BeFree |
umls:C0993582 | Arthritis, Experimental | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |