TissGeneSummary for TINAG |
Gene summary |
Basic gene information | Gene symbol | TINAG |
Gene name | tubulointerstitial nephritis antigen | |
Synonyms | TIN-AG | |
Cytomap | UCSC genome browser: 6p12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_014464.3, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | MIM : 606749 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137251 | ||
HPRD : 09483 | ||
Vega : OTTHUMG00000014893 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TINAG | |
BioGPS: 27283 | ||
Pathway | NCI Pathway Interaction Database: TINAG | |
KEGG: TINAG | ||
REACTOME: TINAG | ||
Pathway Commons: TINAG | ||
Context | iHOP: TINAG | |
ligand binding site mutation search in PubMed: TINAG | ||
UCL Cancer Institute: TINAG | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of TINAG | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007155 | cell adhesion | 8770961 | GO:0007155 | cell adhesion | 8770961 |
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TissGeneExp for TINAG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 3.703783531 | 5.988702761 | -2.284919231 | 1.65E-05 | 7.20E-05 |
KICH | 0.616986915 | 5.287754915 | -4.670768 | 1.22E-07 | 5.52E-07 |
LIHC | 0.636008915 | -2.063281085 | 2.69929 | 4.00E-06 | 1.87E-05 |
ESCA | 1.59204437 | -2.36715563 | 3.9592 | 0.00148 | 0.018916782 |
LUAD | -1.049487292 | -2.311564878 | 1.262077586 | 0.000101 | 0.000255981 |
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TissGene-miRNA for TINAG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TINAG |
TissGeneSNV for TINAG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R191C | SKCM | 3 |
p.R191H | BLCA | 2 |
p.R157C | SKCM | 2 |
p.G233S | SKCM | 2 |
p.R332W | BRCA | 2 |
p.R46Q | SKCM | 2 |
p.E367X | COAD | 2 |
p.R263Q | SKCM | 2 |
p.E128K | SKCM | 2 |
p.W438C | LUAD | 2 |
p.E401K | SKCM | 2 |
p.R255Q | HNSC | 1 |
p.L217I | COAD | 1 |
p.E32D | ESCA | 1 |
p.S247F | SKCM | 1 |
p.A266V | STAD | 1 |
p.R191C | GBM | 1 |
p.C338* | CESC | 1 |
p.R263* | SKCM | 1 |
p.Q26* | BRCA | 1 |
p.T471M | GBM | 1 |
p.R191H | LGG | 1 |
p.R191H | LUAD | 1 |
p.M19I | SKCM | 1 |
p.E403K | SKCM | 1 |
p.Y12H | SKCM | 1 |
p.E128X | THYM | 1 |
p.R347S | LUAD | 1 |
p.R37K | LUSC | 1 |
p.E429K | SKCM | 1 |
p.S203R | OV | 1 |
p.L42F | ESCA | 1 |
p.E401* | LUAD | 1 |
p.E90D | PAAD | 1 |
p.P96S | SKCM | 1 |
p.S11Y | LGG | 1 |
p.E219A | STAD | 1 |
p.N436H | LUAD | 1 |
p.R406X | STAD | 1 |
p.E20K | SKCM | 1 |
p.W244* | SKCM | 1 |
p.C137F | ACC | 1 |
p.D290N | SKCM | 1 |
p.R406* | PAAD | 1 |
p.P308L | SKCM | 1 |
p.E382K | SKCM | 1 |
p.R255Q | UCEC | 1 |
p.K238I | SKCM | 1 |
p.V41I | UCEC | 1 |
p.S345Y | LUAD | 1 |
p.R332Q | KICH | 1 |
p.T40P | BLCA | 1 |
p.W230X | SKCM | 1 |
p.Q163X | LIHC | 1 |
p.E429G | SARC | 1 |
p.Q163* | LIHC | 1 |
p.M200K | LUAD | 1 |
p.E206* | PCPG | 1 |
p.S177I | UCEC | 1 |
p.R191C | LGG | 1 |
p.L80S | BLCA | 1 |
p.G187C | LIHC | 1 |
p.D84N | SKCM | 1 |
p.Q271R | STAD | 1 |
p.D290N | UCEC | 1 |
p.L451R | PAAD | 1 |
p.G54V | ESCA | 1 |
p.G439E | SKCM | 1 |
p.S100C | SKCM | 1 |
p.E162* | PRAD | 1 |
p.K238N | LGG | 1 |
p.M365I | THYM | 1 |
p.D312Y | STAD | 1 |
p.P339A | LUSC | 1 |
p.E367K | SKCM | 1 |
p.Y349S | UCEC | 1 |
p.R332W | KIRC | 1 |
p.W18* | SKCM | 1 |
p.A376_splice | LUSC | 1 |
p.W230* | SKCM | 1 |
p.V41F | LUAD | 1 |
p.E64K | SKCM | 1 |
p.A292T | SKCM | 1 |
p.R191H | UCEC | 1 |
p.E185Q | BRCA | 1 |
p.A76V | UCEC | 1 |
p.R299C | OV | 1 |
p.K6N | READ | 1 |
p.S437F | SKCM | 1 |
p.T416I | LIHC | 1 |
p.R263X | SKCM | 1 |
p.D123N | SKCM | 1 |
p.A77V | UCEC | 1 |
p.E401* | UCEC | 1 |
p.L273S | SKCM | 1 |
p.P353T | HNSC | 1 |
p.Q370* | PRAD | 1 |
p.F310S | ESCA | 1 |
p.A334V | LIHC | 1 |
p.I348V | STAD | 1 |
p.E444* | BRCA | 1 |
p.E444X | ESCA | 1 |
p.A376S | UCEC | 1 |
p.S457P | KIRC | 1 |
p.E135K | SARC | 1 |
p.L309P | KIRP | 1 |
p.V380F | LUAD | 1 |
p.E118K | SKCM | 1 |
p.R299H | STAD | 1 |
p.M182I | UCEC | 1 |
p.G423V | LUAD | 1 |
p.E32K | SKCM | 1 |
p.P476L | SKCM | 1 |
p.Q370X | PRAD | 1 |
p.R191C | HNSC | 1 |
p.R406Q | SKCM | 1 |
p.R406X | PAAD | 1 |
p.T231I | STAD | 1 |
p.C351G | OV | 1 |
p.R191C | CESC | 1 |
p.T362S | KIRP | 1 |
p.R406Q | PRAD | 1 |
p.M182I | LIHC | 1 |
p.R281S | STAD | 1 |
p.W244X | SKCM | 1 |
p.R46L | HNSC | 1 |
p.F179I | STAD | 1 |
p.A465T | LUAD | 1 |
p.E444D | READ | 1 |
p.D290G | ESCA | 1 |
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TissGeneCNV for TINAG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TINAG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TINAG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TINAG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TINAG |
TissGeneDrug for TINAG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TINAG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011881 | Diabetic Nephropathy | 1 | CTD_human |
umls:C0022658 | Kidney Diseases | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |