 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for TP53TG5 |
 Gene summary |
| Basic gene information | Gene symbol | TP53TG5 |
| Gene name | TP53 target 5 | |
| Synonyms | C20orf10|CLG01 | |
| Cytomap | UCSC genome browser: 20q13.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014477.2, | |
| Description | TP53-inducible gene 5 proteinTP53-target gene 5 protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 12733 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TP53TG5 | |
| BioGPS: 27296 | ||
| Pathway | NCI Pathway Interaction Database: TP53TG5 | |
| KEGG: TP53TG5 | ||
| REACTOME: TP53TG5 | ||
| Pathway Commons: TP53TG5 | ||
| Context | iHOP: TP53TG5 | |
| ligand binding site mutation search in PubMed: TP53TG5 | ||
| UCL Cancer Institute: TP53TG5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of TP53TG5 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for TP53TG5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for TP53TG5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for TP53TG5 |
| TissGeneSNV for TP53TG5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N96K | KIRC | 7 |
| p.N96H | KIRC | 5 |
| p.N97D | ESCA | 2 |
| p.A222T | SKCM | 1 |
| p.S229P | STAD | 1 |
| p.K122N | UCEC | 1 |
| p.T179I | SKCM | 1 |
| p.E98A | PAAD | 1 |
| p.P254A | BRCA | 1 |
| p.E25* | OV | 1 |
| p.T143M | LGG | 1 |
| p.A264V | STAD | 1 |
| p.R23Q | COAD | 1 |
| p.K78N | KIRP | 1 |
| p.V133M | COAD | 1 |
| p.E141Q | BLCA | 1 |
| p.D203N | SKCM | 1 |
| p.E25Q | OV | 1 |
| p.Q101K | ESCA | 1 |
| p.K108R | KIRC | 1 |
| p.W271C | CESC | 1 |
| p.L62M | STAD | 1 |
| p.A245T | PRAD | 1 |
| p.N96K | COAD | 1 |
| p.R269G | SARC | 1 |
| p.R175K | SKCM | 1 |
| p.R265T | CESC | 1 |
| p.A5V | OV | 1 |
| p.W252* | PRAD | 1 |
| p.S112Y | THYM | 1 |
| p.S75I | BLCA | 1 |
| p.P215H | LUAD | 1 |
| p.Q18K | ESCA | 1 |
| p.R68M | KIRP | 1 |
| p.A146V | UCEC | 1 |
| p.R241H | SKCM | 1 |
| p.R217* | UCEC | 1 |
| p.N91Y | LUAD | 1 |
| p.E107K | STAD | 1 |
| p.S15P | UCEC | 1 |
| p.G104R | PRAD | 1 |
| p.S230F | BLCA | 1 |
| p.R233H | HNSC | 1 |
| p.Q95K | ESCA | 1 |
| p.A222V | STAD | 1 |
| p.V225M | STAD | 1 |
| Top |
| TissGeneCNV for TP53TG5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for TP53TG5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for TP53TG5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TP53TG5, HNF4A (tumor) | TP53TG5, HNF4A (normal) |
 |  |
| Top |
| TissGeneProg for TP53TG5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for TP53TG5 |
| TissGeneDrug for TP53TG5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for TP53TG5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |