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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ANGPTL3
check button Gene summary
Basic gene informationGene symbolANGPTL3
Gene nameangiopoietin-like 3
SynonymsANG-5|ANGPT5|ANL3|FHBL2
CytomapUCSC genome browser: 1p31.3
Type of geneprotein-coding
RefGenesNM_014495.3,
Descriptionangiopoietin 5angiopoietin-related protein 3
Modification date20141211
dbXrefs MIM : 604774
HGNC : HGNC
Ensembl : ENSG00000132855
HPRD : 10381
Vega : OTTHUMG00000009146
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ANGPTL3
BioGPS: 27329
PathwayNCI Pathway Interaction Database: ANGPTL3
KEGG: ANGPTL3
REACTOME: ANGPTL3
Pathway Commons: ANGPTL3
ContextiHOP: ANGPTL3
ligand binding site mutation search in PubMed: ANGPTL3
UCL Cancer Institute: ANGPTL3
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of ANGPTL3
Description by TissGene annotationsTissgsKTS
CNV gained TissGeneKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006071glycerol metabolic process12565906
GO:0006631fatty acid metabolic process12565906
GO:0006644phospholipid metabolic process17110602
GO:0007165signal transduction11877390
GO:0008203cholesterol metabolic process17110602
GO:0009395phospholipid catabolic process17110602
GO:0010519negative regulation of phospholipase activity17110602
GO:0019915lipid storage12565906
GO:0030335positive regulation of cell migration11877390
GO:0042632cholesterol homeostasis17110602
GO:0045766positive regulation of angiogenesis11877390
GO:0050996positive regulation of lipid catabolic process12565906
GO:0051005negative regulation of lipoprotein lipase activity17110602
GO:0055088lipid homeostasis17110602
GO:0055090acylglycerol homeostasis17110602
GO:0055091phospholipid homeostasis17110602
GO:0006071glycerol metabolic process12565906
GO:0006631fatty acid metabolic process12565906
GO:0006644phospholipid metabolic process17110602
GO:0007165signal transduction11877390
GO:0008203cholesterol metabolic process17110602
GO:0009395phospholipid catabolic process17110602
GO:0010519negative regulation of phospholipase activity17110602
GO:0019915lipid storage12565906
GO:0030335positive regulation of cell migration11877390
GO:0042632cholesterol homeostasis17110602
GO:0045766positive regulation of angiogenesis11877390
GO:0050996positive regulation of lipid catabolic process12565906
GO:0051005negative regulation of lipoprotein lipase activity17110602
GO:0055088lipid homeostasis17110602
GO:0055090acylglycerol homeostasis17110602
GO:0055091phospholipid homeostasis17110602


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TissGeneExp for ANGPTL3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC2.6760895665.999668733-3.3235791671.81E-138.18E-13
PRAD-0.166740455-1.7983289171.6315884626.64E-063.92E-05
LIHC9.64558062211.27737462-1.6317945.74E-062.58E-05
KICH-1.3844973785.532242622-6.916745.18E-182.48E-16
KIRP0.1625513726.152882622-5.990331256.49E-162.11E-14
STAD-1.550711128-0.307408003-1.2433031250.01060.036120303


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TissGene-miRNA for ANGPTL3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ANGPTL3
TissGeneSNV for ANGPTL3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S215YUCEC2
p.L231FCESC1
p.V14IUCEC1
p.I196KLUSC1
p.F167SBRCA1
p.F392LUCEC1
p.R221TBRCA1
p.L309FUCEC1
p.E210*UCEC1
p.D184EUCEC1
p.E143QBLCA1
p.S327CBLCA1
p.S217CBLCA1
p.N371SSTAD1
p.F295LLUSC1
p.Q192HUCEC1
p.L29ISKCM1
p.Q437KCOAD1
p.A193TSTAD1
p.E213*LUSC1
p.L309VESCA1
p.D184ELUAD1
p.S433PSTAD1
p.S217YESCA1
p.E312KLUAD1
p.L57HKIRC1
p.K319MSKCM1
p.K197QUCEC1
p.R252TBLCA1
p.K416TLIHC1
p.L379VPAAD1
p.R332*UCEC1
p.I422MLIHC1
p.P57QKIRC1
p.R332QREAD1
p.A364VUCEC1
p.I214NKIRP1
p.E233KSKCM1
p.H193NSTAD1
p.H343YHNSC1
p.D41NHNSC1
p.K379EPAAD1
p.D441HSTAD1
p.Q195*HNSC1
p.P395SLUAD1


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TissGeneCNV for ANGPTL3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ANGPTL3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for ANGPTL3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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COAD (tumor)COAD (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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HNSC (tumor)HNSC (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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KICH (tumor)KICH (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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KIRC (tumor)KIRC (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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KIRP (tumor)KIRP (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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LIHC (tumor)LIHC (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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LUAD (tumor)LUAD (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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LUSC (tumor)LUSC (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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PRAD (tumor)PRAD (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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STAD (tumor)STAD (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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THCA (tumor)THCA (normal)
ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (tumor)ANGPTL3, NR1H3, ITGAV, ITGB3, HNF1A, ITGA5 (normal)
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TissGeneProg for ANGPTL3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ANGPTL3
TissGeneDrug for ANGPTL3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ANGPTL3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020597Hypobetalipoproteinemias5BeFree
umls:C1862596Familial hypobetalipoproteinemia3BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0004153Atherosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree,GAD
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2GAD
umls:C0020473Hyperlipidemia2BeFree
umls:C0020557Hypertriglyceridemia2GAD
umls:C0028754Obesity2BeFree
umls:C0242339Dyslipidemias2BeFree,GAD
umls:C0524620Metabolic Syndrome X2BeFree
umls:C1522137Hypertriglyceridemia result2GAD
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0015695Fatty Liver1BeFree
umls:C0020459Hyperinsulinism1BeFree
umls:C0021368Inflammation1GAD
umls:C0021655Insulin Resistance1GAD
umls:C0025517Metabolic Diseases1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0154251Lipid Metabolism Disorders1GAD
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0542037Hypotriglyceridaemia1BeFree
umls:C0796095Opitz trigonocephaly syndrome1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree
umls:C1857970Hypobetalipoproteinemia, Familial, 20CTD_human