TissGeneSummary for GML |
Gene summary |
Basic gene information | Gene symbol | GML |
Gene name | glycosylphosphatidylinositol anchored molecule like | |
Synonyms | LY6DL | |
Cytomap | UCSC genome browser: 8q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_002066.2, | |
Description | GPI anchored molecule like proteinGlycosylphosphatidylinositol-anchored molecule-like proteinglycosyl-phosphatidylinositol-anchored molecule-like proteinglycosylphosphatidylinositol anchored molecule like protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 602370 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104499 | ||
HPRD : 03844 | ||
Vega : OTTHUMG00000164656 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GML | |
BioGPS: 2765 | ||
Pathway | NCI Pathway Interaction Database: GML | |
KEGG: GML | ||
REACTOME: GML | ||
Pathway Commons: GML | ||
Context | iHOP: GML | |
ligand binding site mutation search in PubMed: GML | ||
UCL Cancer Institute: GML | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Adrenal glandTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PCPG,ACCTGCT | |
Reference showing the relevant tissue of GML | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GML |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for GML |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GML |
TissGeneSNV for GML |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G91E | SKCM | 3 |
p.G135E | SKCM | 2 |
p.K95T | ESCA | 1 |
p.G135* | UCEC | 1 |
p.Y70H | DLBC | 1 |
p.P133L | LUAD | 1 |
p.R22H | STAD | 1 |
p.L144M | COAD | 1 |
p.R22H | COAD | 1 |
p.F99Y | BLCA | 1 |
p.D125N | GBM | 1 |
p.R120M | READ | 1 |
p.E66K | SKCM | 1 |
p.D121N | SKCM | 1 |
p.G91R | SKCM | 1 |
p.E134* | UCEC | 1 |
p.C31Y | LGG | 1 |
p.G114V | LUSC | 1 |
p.P49L | COAD | 1 |
p.L12F | SKCM | 1 |
p.D39H | LUAD | 1 |
p.K71N | HNSC | 1 |
p.E130V | SKCM | 1 |
p.R22H | HNSC | 1 |
p.R65C | LUAD | 1 |
p.R65C | SKCM | 1 |
p.P124H | SKCM | 1 |
p.S59F | SKCM | 1 |
p.R120M | STAD | 1 |
p.E126X | COAD | 1 |
p.P49S | SKCM | 1 |
p.V141A | STAD | 1 |
p.E134D | COAD | 1 |
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TissGeneCNV for GML |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GML |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-67-3771-01A | GML-C8orf47 | In-frame | Chr8:143922641 | Chr8:99101304 |
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TissGeneNet for GML |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GML |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GML |
TissGeneDrug for GML |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GML |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |