TissGeneSummary for AMY2A |
Gene summary |
Basic gene information | Gene symbol | AMY2A |
Gene name | amylase, alpha 2A (pancreatic) | |
Synonyms | AMY2|AMY2B|PA | |
Cytomap | UCSC genome browser: 1p21 | |
Type of gene | protein-coding | |
RefGenes | NM_000699.2, | |
Description | 1,4-alpha-D-glucan glucanohydrolasealpha-amylaseamylase, pancreatic, alpha-2Afound in the pancreasglycogenasepancreatic alpha-amylasepancreatic amylase 2Apancreatic amylase alpha 2A | |
Modification date | 20141207 | |
dbXrefs | MIM : 104650 | |
HGNC : HGNC | ||
Ensembl : ENSG00000243480 | ||
HPRD : 00094 | ||
Vega : OTTHUMG00000011023 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AMY2A | |
BioGPS: 279 | ||
Pathway | NCI Pathway Interaction Database: AMY2A | |
KEGG: AMY2A | ||
REACTOME: AMY2A | ||
Pathway Commons: AMY2A | ||
Context | iHOP: AMY2A | |
ligand binding site mutation search in PubMed: AMY2A | ||
UCL Cancer Institute: AMY2A | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of AMY2A | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016052 | carbohydrate catabolic process | 10769135 | GO:0016052 | carbohydrate catabolic process | 10769135 |
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TissGeneExp for AMY2A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.895784895 | 0.815662164 | -1.711447059 | 6.08E-10 | 2.13E-09 |
HNSC | -2.160415492 | -0.387436422 | -1.77297907 | 0.000233 | 0.000936161 |
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TissGene-miRNA for AMY2A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AMY2A |
TissGeneSNV for AMY2A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R25W | HNSC | 1 |
p.R25P | LUAD | 1 |
p.Q56H | STAD | 1 |
p.E75K | SKCM | 1 |
p.G51E | SKCM | 1 |
p.P19Q | LUAD | 1 |
p.R76I | CESC | 1 |
p.Q16* | BLCA | 1 |
p.F12L | UCEC | 1 |
p.P79A | LUAD | 1 |
p.E384* | UCEC | 1 |
p.G54E | SKCM | 1 |
p.P59S | BLCA | 1 |
p.V80G | ESCA | 1 |
p.G435V | OV | 1 |
p.R35Q | COAD | 1 |
p.P49T | SKCM | 1 |
p.G89A | LIHC | 1 |
p.C13X | KIRC | 1 |
p.P49S | BLCA | 1 |
p.E93K | LUAD | 1 |
p.A15T | LIHC | 1 |
p.I66V | STAD | 1 |
p.P79Q | UCS | 1 |
p.E62X | READ | 1 |
p.T99N | ESCA | 1 |
p.R402G | DLBC | 1 |
p.E62K | SKCM | 1 |
p.V280I | CESC | 1 |
p.M217T | ESCA | 1 |
p.V64I | HNSC | 1 |
p.G253C | LUAD | 1 |
p.P72H | LUAD | 1 |
p.Y46D | PAAD | 1 |
p.A207T | UCEC | 1 |
p.E186D | UCEC | 1 |
p.G89E | SKCM | 1 |
p.D251N | SKCM | 1 |
p.G54E | STAD | 1 |
p.A40V | PAAD | 1 |
p.S27Y | BLCA | 1 |
p.S234C | BRCA | 1 |
p.Q16L | CESC | 1 |
p.G53R | PAAD | 1 |
p.R76I | LIHC | 1 |
p.V80F | HNSC | 1 |
p.Y17H | LUAD | 1 |
p.S132R | UCEC | 1 |
p.H216L | UCEC | 1 |
p.P59Q | LUAD | 1 |
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TissGeneCNV for AMY2A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AMY2A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for AMY2A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AMY2A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AMY2A |
TissGeneDrug for AMY2A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00284 | Acarbose | Inhibitor | Small molecule | Approved|Investigational |
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TissGeneDisease for AMY2A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0011570 | Mental Depression | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0030305 | Pancreatitis | 1 | LHGDN |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |