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| TissGeneSummary for GP2 |
 Gene summary |
| Basic gene information | Gene symbol | GP2 |
| Gene name | glycoprotein 2 (zymogen granule membrane) | |
| Synonyms | ZAP75 | |
| Cytomap | UCSC genome browser: 16p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001007240.1, NM_001007241.1,NM_001007242.1,NM_001502.2, | |
| Description | pancreatic secretory granule membrane major glycoprotein GP2pancreatic zymogen granule membrane associated protein GP2pancreatic zymogen granule membrane protein GP-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602977 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169347 | ||
| HPRD : 04279 | ||
| Vega : OTTHUMG00000131489 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GP2 | |
| BioGPS: 2813 | ||
| Pathway | NCI Pathway Interaction Database: GP2 | |
| KEGG: GP2 | ||
| REACTOME: GP2 | ||
| Pathway Commons: GP2 | ||
| Context | iHOP: GP2 | |
| ligand binding site mutation search in PubMed: GP2 | ||
| UCL Cancer Institute: GP2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of GP2 | GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome. Kobayashi K, Yanagihara K, Ishiguro K, Fukuoka S. Biochem Biophys Res Commun. 2004 Sep 17;322(2):659-64. (pmid:15325280) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 0.974430269 | 4.484461038 | -3.510030769 | 8.52E-07 | 4.87E-06 |
| KIRC | -1.480558407 | 4.739130482 | -6.219688889 | 6.60E-47 | 4.62E-45 |
| KICH | -1.868242962 | 5.831273038 | -7.699516 | 4.99E-17 | 1.83E-15 |
| KIRP | -1.674973337 | 5.382254788 | -7.057228125 | 2.26E-21 | 1.69E-19 |
| HNSC | -1.06145059 | 1.019465689 | -2.080916279 | 0.0025 | 0.007480053 |
| BRCA | 4.309192617 | 3.034239108 | 1.274953509 | 0.00336 | 0.006172323 |
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| TissGene-miRNA for GP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GP2 |
| TissGeneSNV for GP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S41L | SKCM | 4 |
| p.R276C | COAD | 2 |
| p.D340N | COAD | 2 |
| p.E365K | SKCM | 2 |
| p.D86N | SKCM | 2 |
| p.E368K | UCEC | 2 |
| p.V301A | PAAD | 1 |
| p.A384D | COAD | 1 |
| p.P36L | BLCA | 1 |
| p.S478* | LUAD | 1 |
| p.E462K | STAD | 1 |
| p.W141C | LUAD | 1 |
| p.G363V | COAD | 1 |
| p.V152L | LUAD | 1 |
| p.Q289E | THYM | 1 |
| p.A403V | UCEC | 1 |
| p.T403P | HNSC | 1 |
| p.R82K | SKCM | 1 |
| p.P484L | THYM | 1 |
| p.R480H | THCA | 1 |
| p.M5I | SKCM | 1 |
| p.C206F | LUAD | 1 |
| p.G10V | HNSC | 1 |
| p.L526M | BLCA | 1 |
| p.G366W | LUAD | 1 |
| p.S468Y | UCEC | 1 |
| p.A281P | LUSC | 1 |
| p.R31* | LGG | 1 |
| p.S484I | HNSC | 1 |
| p.L354F | LUAD | 1 |
| p.S476T | BRCA | 1 |
| p.R393Q | PAAD | 1 |
| p.L456R | SKCM | 1 |
| p.T401N | LUAD | 1 |
| p.D211N | KIRC | 1 |
| p.Q83H | LUSC | 1 |
| p.G199E | SKCM | 1 |
| p.S104L | STAD | 1 |
| p.E233* | UCEC | 1 |
| p.G347E | LUSC | 1 |
| p.I308T | LUSC | 1 |
| p.Q224X | KIRC | 1 |
| p.S41L | COAD | 1 |
| p.S222N | LUSC | 1 |
| p.G159R | KIRC | 1 |
| p.E187D | UCEC | 1 |
| p.V376F | LUSC | 1 |
| p.S389F | BLCA | 1 |
| p.T53I | SKCM | 1 |
| p.R254* | LUAD | 1 |
| p.M511I | UCEC | 1 |
| p.V301A | PCPG | 1 |
| p.P51L | LUAD | 1 |
| p.F394V | DLBC | 1 |
| p.V491A | ESCA | 1 |
| p.A50V | SKCM | 1 |
| p.A127D | LUSC | 1 |
| p.V304A | PAAD | 1 |
| p.E289X | ACC | 1 |
| p.S142I | PRAD | 1 |
| p.P54T | LUAD | 1 |
| p.R94S | OV | 1 |
| p.A505T | ESCA | 1 |
| p.R74Q | COAD | 1 |
| p.G510R | SKCM | 1 |
| p.Q287P | COAD | 1 |
| p.G208C | LUSC | 1 |
| p.H291Y | SKCM | 1 |
| p.E105K | LUAD | 1 |
| p.P2A | BLCA | 1 |
| p.A80T | UCS | 1 |
| p.G346E | SKCM | 1 |
| p.R112Q | SKCM | 1 |
| p.A329V | SKCM | 1 |
| p.R94H | STAD | 1 |
| p.E197K | CESC | 1 |
| p.D411N | ESCA | 1 |
| p.G349E | LUSC | 1 |
| p.P54L | SKCM | 1 |
| p.G380A | SKCM | 1 |
| p.D308H | BLCA | 1 |
| p.E437K | SKCM | 1 |
| p.E459K | STAD | 1 |
| p.R165L | STAD | 1 |
| p.S41L | UCEC | 1 |
| p.A28T | HNSC | 1 |
| p.N342K | ESCA | 1 |
| p.R112L | LUAD | 1 |
| p.E268Q | LUSC | 1 |
| p.M447V | LUSC | 1 |
| p.G369W | LUAD | 1 |
| p.R229K | SKCM | 1 |
| p.S190F | SKCM | 1 |
| p.S41L | STAD | 1 |
| p.Q221* | KIRC | 1 |
| p.G43R | SKCM | 1 |
| p.S11Y | LUAD | 1 |
| p.D70N | SKCM | 1 |
| p.W171R | LUSC | 1 |
| p.L23M | BLCA | 1 |
| p.S41L | READ | 1 |
| p.S475* | LUAD | 1 |
| p.A384V | THYM | 1 |
| p.L314P | UCEC | 1 |
| p.G347R | LUAD | 1 |
| p.R351S | SKCM | 1 |
| p.R74Q | ESCA | 1 |
| p.Q481K | LUAD | 1 |
| p.Q422* | SKCM | 1 |
| p.S326N | SKCM | 1 |
| p.P522L | SKCM | 1 |
| p.D86N | STAD | 1 |
| p.D311H | BLCA | 1 |
| p.T53N | LUAD | 1 |
| p.D340N | READ | 1 |
| p.T406P | HNSC | 1 |
| p.E139X | ACC | 1 |
| p.P51T | LUAD | 1 |
| p.E286* | ACC | 1 |
| p.W15L | LUAD | 1 |
| p.A534P | DLBC | 1 |
| p.R483C | UCEC | 1 |
| p.V494A | ESCA | 1 |
| p.W92S | LUAD | 1 |
| p.L492R | ACC | 1 |
| p.G160R | STAD | 1 |
| p.L529M | BLCA | 1 |
| p.S481I | HNSC | 1 |
| p.T24I | SKCM | 1 |
| p.E167K | SKCM | 1 |
| p.Q478K | LUAD | 1 |
| p.R390Q | PAAD | 1 |
| p.I37V | LIHC | 1 |
| p.S337F | SKCM | 1 |
| p.P487L | THYM | 1 |
| p.P62H | SKCM | 1 |
| p.G123W | PRAD | 1 |
| p.E289D | UCEC | 1 |
| p.V304A | PCPG | 1 |
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| TissGeneCNV for GP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for GP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| COAD (tumor) | COAD (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| KICH (tumor) | KICH (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| STAD (tumor) | STAD (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| THCA (tumor) | THCA (normal) |
| GP2, AMY2A, SOX30, ANXA4, TSSK3 (tumor) | GP2, AMY2A, SOX30, ANXA4, TSSK3 (normal) |
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| TissGeneProg for GP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GP2 |
| TissGeneDrug for GP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0149521 | Pancreatitis, Chronic | 2 | BeFree,GAD |
| umls:C0005910 | Body Weight | 1 | CTD_human |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
| umls:C0019097 | Hemorrhagic Fever, Argentinian | 1 | BeFree |
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