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| TissGeneSummary for SLCO1B3 |
 Gene summary |
| Basic gene information | Gene symbol | SLCO1B3 |
| Gene name | solute carrier organic anion transporter family, member 1B3 | |
| Synonyms | HBLRR|LST-2|LST-3TM13|LST3|OATP-8|OATP1B3|OATP8|SLC21A8 | |
| Cytomap | UCSC genome browser: 12p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_019844.3, | |
| Description | liver-specific organic anion transporter 2liver-specific organic anion transporter 3TM13organic anion transporter 8organic anion transporter LST-3corganic anion-transporting polypeptide 8solute carrier family 21 (organic anion transporter), member 8 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 605495 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000111700 | ||
| HPRD : 12021 | ||
| Vega : OTTHUMG00000169011 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLCO1B3 | |
| BioGPS: 28234 | ||
| Pathway | NCI Pathway Interaction Database: SLCO1B3 | |
| KEGG: SLCO1B3 | ||
| REACTOME: SLCO1B3 | ||
| Pathway Commons: SLCO1B3 | ||
| Context | iHOP: SLCO1B3 | |
| ligand binding site mutation search in PubMed: SLCO1B3 | ||
| UCL Cancer Institute: SLCO1B3 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SLCO1B3 | ||
| Description by TissGene annotations | Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLCO1B3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 3.454485843 | 9.875171843 | -6.420686 | 1.66E-13 | 4.01E-12 |
| LUSC | 1.297223647 | -1.128850863 | 2.42607451 | 1.42E-06 | 3.48E-06 |
| LUAD | 0.889232809 | -1.386739605 | 2.275972414 | 9.86E-07 | 3.32E-06 |
| HNSC | 3.791495238 | 0.133151052 | 3.658344186 | 1.96E-08 | 2.21E-07 |
| COAD | 3.338706151 | -0.625020772 | 3.963726923 | 2.10E-06 | 1.11E-05 |
| ESCA | 3.548150207 | -0.130958884 | 3.679109091 | 0.00167 | 0.020633778 |
| PRAD | 1.105273459 | -0.417807311 | 1.523080769 | 0.00204 | 0.005983822 |
| STAD | 2.301563843 | -1.017154907 | 3.31871875 | 3.23E-05 | 0.000300176 |
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| TissGene-miRNA for SLCO1B3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLCO1B3 |
| TissGeneSNV for SLCO1B3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G315E | SKCM | 5 |
| p.S415L | SKCM | 3 |
| p.S293L | SKCM | 3 |
| p.E471K | SKCM | 3 |
| p.R515K | SKCM | 3 |
| p.P427S | SKCM | 2 |
| p.S411L | SKCM | 2 |
| p.P384S | SKCM | 2 |
| p.S545F | SKCM | 2 |
| p.D596N | SKCM | 2 |
| p.G584E | SKCM | 2 |
| p.G216E | SKCM | 2 |
| p.H4N | LIHC | 1 |
| p.K649R | THYM | 1 |
| p.D251H | ESCA | 1 |
| p.F535C | MESO | 1 |
| p.K657N | LUAD | 1 |
| p.E74D | UCEC | 1 |
| p.Q652X | SKCM | 1 |
| p.R57S | SARC | 1 |
| p.Y651C | STAD | 1 |
| p.P280S | SKCM | 1 |
| p.G219C | LUAD | 1 |
| p.V638A | STAD | 1 |
| p.G119R | SKCM | 1 |
| p.T385M | ESCA | 1 |
| p.V560L | KIRC | 1 |
| p.P649S | CESC | 1 |
| p.Y208H | READ | 1 |
| p.S85R | ESCA | 1 |
| p.Q307* | SKCM | 1 |
| p.R181C | SKCM | 1 |
| p.P220L | SKCM | 1 |
| p.G552D | LUAD | 1 |
| p.A519V | GBM | 1 |
| p.L377W | STAD | 1 |
| p.G551E | SKCM | 1 |
| p.E56K | LIHC | 1 |
| p.S35T | ESCA | 1 |
| p.S295L | SKCM | 1 |
| p.K399X | SKCM | 1 |
| p.C660F | LUAD | 1 |
| p.T385R | LUAD | 1 |
| p.E431K | SKCM | 1 |
| p.F268L | BRCA | 1 |
| p.D596N | LUSC | 1 |
| p.C524S | BLCA | 1 |
| p.G573R | HNSC | 1 |
| p.S461L | BLCA | 1 |
| p.E431K | UCEC | 1 |
| p.S135L | SKCM | 1 |
| p.G688S | KICH | 1 |
| p.G685R | SKCM | 1 |
| p.F645V | ESCA | 1 |
| p.G478V | STAD | 1 |
| p.E364Q | KIRP | 1 |
| p.D687H | HNSC | 1 |
| p.F199V | LUAD | 1 |
| p.T153I | KIRC | 1 |
| p.G394E | SKCM | 1 |
| p.E672* | LUAD | 1 |
| p.S415L | UCEC | 1 |
| p.Y362H | SKCM | 1 |
| p.F117V | BLCA | 1 |
| p.A612V | SKCM | 1 |
| p.R671* | GBM | 1 |
| p.G669V | LUSC | 1 |
| p.P131T | LIHC | 1 |
| p.G683V | LUAD | 1 |
| p.P94Q | STAD | 1 |
| p.G203R | SKCM | 1 |
| p.M179I | PAAD | 1 |
| p.S89C | LUAD | 1 |
| p.S16* | HNSC | 1 |
| p.T659M | BLCA | 1 |
| p.V473I | UCEC | 1 |
| p.P283S | SKCM | 1 |
| p.R253L | UCEC | 1 |
| p.P472S | SKCM | 1 |
| p.D453V | STAD | 1 |
| p.Q725K | LUSC | 1 |
| p.E74K | LUSC | 1 |
| p.R633I | BLCA | 1 |
| p.P275S | SKCM | 1 |
| p.G677C | LUAD | 1 |
| p.S62F | SKCM | 1 |
| p.G266* | LUAD | 1 |
| p.S418F | SKCM | 1 |
| p.S411* | SKCM | 1 |
| p.G683V | STAD | 1 |
| p.S411X | SKCM | 1 |
| p.Q3K | STAD | 1 |
| p.Q307E | BLCA | 1 |
| p.E185K | SKCM | 1 |
| p.G494S | SKCM | 1 |
| p.E202Q | HNSC | 1 |
| p.D596Y | PAAD | 1 |
| p.G522S | SKCM | 1 |
| p.L267I | HNSC | 1 |
| p.G98R | HNSC | 1 |
| p.V619I | LGG | 1 |
| p.K399* | SKCM | 1 |
| p.K41I | BLCA | 1 |
| p.R580K | LUAD | 1 |
| p.D161N | PAAD | 1 |
| p.F643I | BLCA | 1 |
| p.P682L | LGG | 1 |
| p.S545P | SKCM | 1 |
| p.R305K | BLCA | 1 |
| p.L647V | LUSC | 1 |
| p.I237T | LGG | 1 |
| p.S295* | UCS | 1 |
| p.G44S | SKCM | 1 |
| p.Q575H | STAD | 1 |
| p.C142F | KIRC | 1 |
| p.R253P | BLCA | 1 |
| p.K657R | BLCA | 1 |
| p.G552S | SKCM | 1 |
| p.G266R | SKCM | 1 |
| p.H636Y | STAD | 1 |
| p.S252F | UCEC | 1 |
| p.G88R | SKCM | 1 |
| p.W663* | LUSC | 1 |
| p.F591V | HNSC | 1 |
| p.P283L | SKCM | 1 |
| p.V454L | STAD | 1 |
| p.F230L | HNSC | 1 |
| p.P472L | SKCM | 1 |
| p.Q575* | UCEC | 1 |
| p.S51F | SKCM | 1 |
| p.F356V | BRCA | 1 |
| p.D687N | BLCA | 1 |
| p.T382P | UCS | 1 |
| p.F535S | UCEC | 1 |
| p.S228P | ESCA | 1 |
| p.G634S | UCEC | 1 |
| p.S295* | UCEC | 1 |
| p.E662D | SKCM | 1 |
| p.S252Y | STAD | 1 |
| p.V163L | SKCM | 1 |
| p.E508K | SKCM | 1 |
| p.D655N | SKCM | 1 |
| p.T334I | LGG | 1 |
| p.F419L | BLCA | 1 |
| p.D716Y | LUAD | 1 |
| p.S112F | HNSC | 1 |
| p.P455A | BRCA | 1 |
| p.F117V | STAD | 1 |
| p.P635Q | STAD | 1 |
| p.D198N | SKCM | 1 |
| p.S35P | READ | 1 |
| p.T345S | LUAD | 1 |
| p.F634L | LUAD | 1 |
| p.V452A | STAD | 1 |
| p.Q422* | SKCM | 1 |
| p.E165K | BLCA | 1 |
| p.N692T | ESCA | 1 |
| p.M600I | SKCM | 1 |
| p.Y481F | BRCA | 1 |
| p.D2N | SKCM | 1 |
| p.K250N | KIRC | 1 |
| p.R515I | UCEC | 1 |
| p.E289K | SKCM | 1 |
| p.I274L | LUSC | 1 |
| p.D737N | LUSC | 1 |
| p.G394R | SKCM | 1 |
| p.S434L | SKCM | 1 |
| p.K533N | COAD | 1 |
| p.G88A | PAAD | 1 |
| p.Q652* | SKCM | 1 |
| p.N375T | STAD | 1 |
| p.D527E | SKCM | 1 |
| p.S138R | ESCA | 1 |
| p.L212V | COAD | 1 |
| p.K561N | ESCA | 1 |
| p.C489Y | CHOL | 1 |
| p.S618F | SKCM | 1 |
| p.G71V | SKCM | 1 |
| p.Q422X | SKCM | 1 |
| p.S468R | STAD | 1 |
| p.D596H | BRCA | 1 |
| p.P220S | HNSC | 1 |
| p.D737N | UCEC | 1 |
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| TissGeneCNV for SLCO1B3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLCO1B3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-86-7701-01A | ETV6-SLCO1B3 | In-Frame | chr12:11992237 | chr12:21027902 |
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| TissGeneNet for SLCO1B3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| STAD (tumor) | STAD (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| THCA (tumor) | THCA (normal) |
| SLCO1B3, RXRA, NR1H4 (tumor) | SLCO1B3, RXRA, NR1H4 (normal) |
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| TissGeneProg for SLCO1B3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLCO1B3 |
| TissGeneDrug for SLCO1B3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLCO1B3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0220991 | Rotor Syndrome | 4 | BeFree,CLINVAR,ORPHANET |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 4 | BeFree,LHGDN |
| umls:C0023473 | Myeloid Leukemia, Chronic | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree,RGD |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0008370 | Cholestasis | 2 | BeFree,RGD |
| umls:C0020433 | Hyperbilirubinemia | 2 | CTD_mouse,GAD |
| umls:C0023530 | Leukopenia | 2 | BeFree,GAD |
| umls:C0027947 | Neutropenia | 2 | BeFree,GAD,LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | CTD_human |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0019188 | Hepatitis, Animal | 1 | RGD |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0020179 | Huntington Disease | 1 | BeFree |
| umls:C0023474 | Leukemia, Myeloid, Chronic-Phase | 1 | GAD |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree,GAD |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0037286 | Skin Neoplasms | 1 | GAD |
| umls:C0041296 | Tuberculosis | 1 | GAD |
| umls:C0079474 | Hallopeau-Siemens Disease | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | GAD |
| umls:C0079774 | Peripheral T-Cell Lymphoma | 1 | GAD |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0268306 | Unconjugated hyperbilirubinemia | 1 | BeFree |
| umls:C0268307 | Conjugated hyperbilirubinemia | 1 | BeFree |
| umls:C0346429 | Multiple malignancy | 1 | BeFree |
| umls:C0553723 | Squamous cell carcinoma of skin | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0855197 | Testicular malignant germ cell tumor | 1 | BeFree |
| umls:C0857007 | Hyperbilirubinemia, Neonatal | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
| umls:C3658266 | Prostatic Cancer, Castration-Resistant | 1 | BeFree |
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