TissGeneSummary for STK32C |
Gene summary |
Basic gene information | Gene symbol | STK32C |
Gene name | serine/threonine kinase 32C | |
Synonyms | PKE|YANK3 | |
Cytomap | UCSC genome browser: 10q26.3 | |
Type of gene | protein-coding | |
RefGenes | NM_173575.2, | |
Description | PKE protein kinaseprotein kinase (PKE)serine/threonine-protein kinase 32Cyet another novel kinase 3 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165752 | ||
HPRD : 18119 | ||
Vega : OTTHUMG00000019285 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STK32C | |
BioGPS: 282974 | ||
Pathway | NCI Pathway Interaction Database: STK32C | |
KEGG: STK32C | ||
REACTOME: STK32C | ||
Pathway Commons: STK32C | ||
Context | iHOP: STK32C | |
ligand binding site mutation search in PubMed: STK32C | ||
UCL Cancer Institute: STK32C | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of STK32C | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for STK32C |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.085687673 | -1.236343923 | 1.15065625 | 1.29E-06 | 2.03E-05 |
BLCA | 0.305744728 | -0.719628956 | 1.025373684 | 0.00314 | 0.018474497 |
KICH | -1.919729798 | -0.412329798 | -1.5074 | 3.98E-05 | 0.000112461 |
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TissGene-miRNA for STK32C |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for STK32C |
TissGeneSNV for STK32C |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K114* | SARC | 1 |
p.A315T | UCEC | 1 |
p.V154A | HNSC | 1 |
p.R353Q | UCEC | 1 |
p.G174V | LUAD | 1 |
p.Q94L | LUAD | 1 |
p.Q187K | UCS | 1 |
p.G291V | LUAD | 1 |
p.R97W | BLCA | 1 |
p.H112Q | CHOL | 1 |
p.L32F | PRAD | 1 |
p.K65N | UCEC | 1 |
p.Q70K | UCS | 1 |
p.M271L | HNSC | 1 |
p.L90M | SKCM | 1 |
p.A366V | SKCM | 1 |
p.G165W | LUAD | 1 |
p.D205Y | LUAD | 1 |
p.V37A | HNSC | 1 |
p.H59Y | MESO | 1 |
p.M388L | HNSC | 1 |
p.A483V | SKCM | 1 |
p.R340Q | UCEC | 1 |
p.D88Y | LUAD | 1 |
p.V315I | THYM | 1 |
p.S172F | LUSC | 1 |
p.A72V | KIRC | 1 |
p.A302T | UCEC | 1 |
p.V266I | DLBC | 1 |
p.S273P | COAD | 1 |
p.Q313* | SKCM | 1 |
p.G282W | LUAD | 1 |
p.M124T | STAD | 1 |
p.R173* | HNSC | 1 |
p.D91Y | LUAD | 1 |
p.D349G | LGG | 1 |
p.N185D | PRAD | 1 |
p.Y421C | LIHC | 1 |
p.N68D | PRAD | 1 |
p.G486S | COAD | 1 |
p.S70W | SKCM | 1 |
p.V434M | UCEC | 1 |
p.R110W | BLCA | 1 |
p.Q107L | LUAD | 1 |
p.S356I | LUSC | 1 |
p.H229Q | CHOL | 1 |
p.D104Y | LUAD | 1 |
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TissGeneCNV for STK32C |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for STK32C |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-DQ-5624-01A | MYO19-STK32C | NA | Chr17:34881059 | Chr10:134137877 |
TCGAfusionPortal | PRADA | SKCM | TCGA-EB-A51B-01A | STK32C-PWWP2B | CDS-3UTR | Chr10:134022538 | Chr10:134230565 |
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TissGeneNet for STK32C |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for STK32C |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for STK32C |
TissGeneDrug for STK32C |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for STK32C |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |