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| TissGeneSummary for MKX |
 Gene summary |
| Basic gene information | Gene symbol | MKX |
| Gene name | mohawk homeobox | |
| Synonyms | C10orf48|IFRX|IRXL1 | |
| Cytomap | UCSC genome browser: 10p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001242702.1, NM_173576.2, | |
| Description | Iroquois family related homeodomain proteinhomeobox protein Mohawkiroquois homeobox protein-like 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601332 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000150051 | ||
| HPRD : 12577 | ||
| Vega : OTTHUMG00000017862 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MKX | |
| BioGPS: 283078 | ||
| Pathway | NCI Pathway Interaction Database: MKX | |
| KEGG: MKX | ||
| REACTOME: MKX | ||
| Pathway Commons: MKX | ||
| Context | iHOP: MKX | |
| ligand binding site mutation search in PubMed: MKX | ||
| UCL Cancer Institute: MKX | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADUCEC,UCS | |
| Reference showing the relevant tissue of MKX | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MKX |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -1.919198937 | -0.455940603 | -1.463258333 | 1.38E-10 | 4.82E-10 |
| STAD | 0.345310091 | 1.954960091 | -1.60965 | 0.00223 | 0.009853183 |
| LIHC | -0.625753159 | 0.675220841 | -1.300974 | 0.0011 | 0.00297939 |
| BLCA | -0.911850106 | 2.136023578 | -3.047873684 | 6.45E-05 | 0.000788176 |
| BRCA | 0.641714806 | 1.664409543 | -1.022694737 | 1.00E-04 | 0.000222507 |
| KICH | 1.444344841 | -0.507255159 | 1.9516 | 6.31E-05 | 0.000172119 |
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| TissGene-miRNA for MKX |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MKX |
| TissGeneSNV for MKX |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R278C | SKCM | 3 |
| p.G243E | SKCM | 3 |
| p.S196L | SKCM | 2 |
| p.V71G | LUAD | 2 |
| p.R133* | SKCM | 1 |
| p.T303M | PAAD | 1 |
| p.K103N | UCEC | 1 |
| p.S286F | SKCM | 1 |
| p.E258X | UCS | 1 |
| p.T303A | COAD | 1 |
| p.K199N | SKCM | 1 |
| p.E283K | SKCM | 1 |
| p.Q247H | LIHC | 1 |
| p.A12T | COAD | 1 |
| p.S110L | SKCM | 1 |
| p.R127Q | COAD | 1 |
| p.E258G | UCEC | 1 |
| p.R156W | PAAD | 1 |
| p.R133X | SKCM | 1 |
| p.G285E | SKCM | 1 |
| p.P185S | SKCM | 1 |
| p.G56C | LUSC | 1 |
| p.H176Q | ESCA | 1 |
| p.V117_splice | LUSC | 1 |
| p.P185Q | HNSC | 1 |
| p.R127W | SKCM | 1 |
| p.G180V | OV | 1 |
| p.N183Y | SKCM | 1 |
| p.S336A | ACC | 1 |
| p.A20T | STAD | 1 |
| p.E205D | STAD | 1 |
| p.E102K | SKCM | 1 |
| p.Y97H | BLCA | 1 |
| p.T245R | SKCM | 1 |
| p.E170K | SKCM | 1 |
| p.R156Q | SKCM | 1 |
| p.E258* | UCS | 1 |
| p.G48C | LUAD | 1 |
| p.G326E | SKCM | 1 |
| p.D168N | SKCM | 1 |
| p.V132A | SKCM | 1 |
| p.Q76H | UCEC | 1 |
| p.P98S | SKCM | 1 |
| p.R225C | PRAD | 1 |
| p.R225H | STAD | 1 |
| p.R207W | STAD | 1 |
| p.L85P | STAD | 1 |
| p.G180R | SKCM | 1 |
| p.E194D | STAD | 1 |
| p.E205Q | LUAD | 1 |
| p.R156W | UCEC | 1 |
| p.S230F | SKCM | 1 |
| p.Y30* | LUSC | 1 |
| p.K129N | LUAD | 1 |
| p.T281I | HNSC | 1 |
| p.R75W | SKCM | 1 |
| p.E307K | SKCM | 1 |
| p.N238D | UCEC | 1 |
| p.G169R | SKCM | 1 |
| p.L222V | UCEC | 1 |
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| TissGeneCNV for MKX |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MKX |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE835454 | MKX-TGFB3 | chr10:27994058 | chr14:76424563 |
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| TissGeneNet for MKX |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| COAD (tumor) | COAD (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| KICH (tumor) | KICH (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| STAD (tumor) | STAD (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| THCA (tumor) | THCA (normal) |
| MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (tumor) | MKX, TBP, ELAVL1, HDAC1, GTF2B, SIN3A, HOXA13, GTF2A1 (normal) |
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| TissGeneProg for MKX |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MKX |
| TissGeneDrug for MKX |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MKX |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010417 | Cryptorchidism | 1 | BeFree |
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