TissGeneSummary for TMPRSS12 |
Gene summary |
Basic gene information | Gene symbol | TMPRSS12 |
Gene name | transmembrane (C-terminal) protease, serine 12 | |
Synonyms | CT151 | |
Cytomap | UCSC genome browser: 12q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_182559.2, | |
Description | transmembrane protease serine 12transmembrane protease, serine 12 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000186452 | ||
HPRD : 07133 | ||
Vega : OTTHUMG00000169483 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMPRSS12 | |
BioGPS: 283471 | ||
Pathway | NCI Pathway Interaction Database: TMPRSS12 | |
KEGG: TMPRSS12 | ||
REACTOME: TMPRSS12 | ||
Pathway Commons: TMPRSS12 | ||
Context | iHOP: TMPRSS12 | |
ligand binding site mutation search in PubMed: TMPRSS12 | ||
UCL Cancer Institute: TMPRSS12 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TMPRSS12 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMPRSS12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TMPRSS12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMPRSS12 |
TissGeneSNV for TMPRSS12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P272S | SKCM | 2 |
p.E62K | COAD | 2 |
p.P248L | SKCM | 2 |
p.G255D | LUAD | 1 |
p.Y19H | COAD | 1 |
p.E114D | UCEC | 1 |
p.A220T | CESC | 1 |
p.L292V | BLCA | 1 |
p.R30K | SKCM | 1 |
p.A287T | SKCM | 1 |
p.T263A | STAD | 1 |
p.Y275X | COAD | 1 |
p.A173V | LUSC | 1 |
p.G255D | SKCM | 1 |
p.R281* | SKCM | 1 |
p.G245* | PAAD | 1 |
p.G202R | SKCM | 1 |
p.D262N | BLCA | 1 |
p.N184I | LUAD | 1 |
p.P68L | UCEC | 1 |
p.R281T | BLCA | 1 |
p.A220T | STAD | 1 |
p.G269E | SKCM | 1 |
p.R145C | KICH | 1 |
p.R145H | SKCM | 1 |
p.E315G | LUAD | 1 |
p.G293D | HNSC | 1 |
p.D185G | COAD | 1 |
p.E228* | BLCA | 1 |
p.R101H | READ | 1 |
p.A88T | HNSC | 1 |
p.N222I | HNSC | 1 |
p.T139I | LUSC | 1 |
p.W312G | LUSC | 1 |
p.R281I | UCEC | 1 |
p.Y275C | BLCA | 1 |
p.V284L | LUAD | 1 |
p.R281I | COAD | 1 |
p.R281G | SKCM | 1 |
p.E235D | UCEC | 1 |
p.Y243C | UCEC | 1 |
p.L317F | SKCM | 1 |
p.E83K | SKCM | 1 |
p.G245X | PAAD | 1 |
p.I142M | UCEC | 1 |
p.E280K | UCS | 1 |
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TissGeneCNV for TMPRSS12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMPRSS12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TMPRSS12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMPRSS12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMPRSS12 |
TissGeneDrug for TMPRSS12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMPRSS12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |