TissGeneSummary for TSSK4 |
Gene summary |
Basic gene information | Gene symbol | TSSK4 |
Gene name | testis-specific serine kinase 4 | |
Synonyms | C14orf20|STK22E|TSK-4|TSK4|TSSK5 | |
Cytomap | UCSC genome browser: 14q12 | |
Type of gene | protein-coding | |
RefGenes | NM_001184739.1, NM_174944.3, | |
Description | serine/threonine kinase 22Eserine/threonine-protein kinase 22Etestis-specific serine/threonine-protein kinase 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610711 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139908 | ||
HPRD : 12642 | ||
Vega : OTTHUMG00000029323 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSSK4 | |
BioGPS: 283629 | ||
Pathway | NCI Pathway Interaction Database: TSSK4 | |
KEGG: TSSK4 | ||
REACTOME: TSSK4 | ||
Pathway Commons: TSSK4 | ||
Context | iHOP: TSSK4 | |
ligand binding site mutation search in PubMed: TSSK4 | ||
UCL Cancer Institute: TSSK4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSSK4 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 15964553 | GO:0032793 | positive regulation of CREB transcription factor activity | 15964553 | GO:0006468 | protein phosphorylation | 15964553 | GO:0032793 | positive regulation of CREB transcription factor activity | 15964553 |
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TissGeneExp for TSSK4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TSSK4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSSK4 |
TissGeneSNV for TSSK4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R281C | UCEC | 2 |
p.H246L | LUSC | 1 |
p.R221X | STAD | 1 |
p.D63N | BLCA | 1 |
p.V227I | STAD | 1 |
p.I92T | GBM | 1 |
p.K78N | STAD | 1 |
p.P188L | CESC | 1 |
p.C199* | LUAD | 1 |
p.P217Q | PRAD | 1 |
p.S274F | SKCM | 1 |
p.R211* | STAD | 1 |
p.M77I | SKCM | 1 |
p.C209* | LUAD | 1 |
p.F228L | LUAD | 1 |
p.D157N | SKCM | 1 |
p.S141I | KIRC | 1 |
p.D167N | SKCM | 1 |
p.L102V | BLCA | 1 |
p.G107S | KICH | 1 |
p.E264D | STAD | 1 |
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TissGeneCNV for TSSK4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSSK4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TSSK4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSSK4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSSK4 |
TissGeneDrug for TSSK4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSSK4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0021364 | Male infertility | 1 | BeFree,GAD,LHGDN |
umls:C0028960 | Oligospermia | 1 | GAD |