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| TissGeneSummary for ANGPT1 |
 Gene summary |
| Basic gene information | Gene symbol | ANGPT1 |
| Gene name | angiopoietin 1 | |
| Synonyms | AGP1|AGPT|ANG1 | |
| Cytomap | UCSC genome browser: 8q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001146.3, NM_001199859.1,NM_139290.1, | |
| Description | ANG-1angiopoietin-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601667 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000154188 | ||
| HPRD : 03392 | ||
| Vega : OTTHUMG00000164812 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANGPT1 | |
| BioGPS: 284 | ||
| Pathway | NCI Pathway Interaction Database: ANGPT1 | |
| KEGG: ANGPT1 | ||
| REACTOME: ANGPT1 | ||
| Pathway Commons: ANGPT1 | ||
| Context | iHOP: ANGPT1 | |
| ligand binding site mutation search in PubMed: ANGPT1 | ||
| UCL Cancer Institute: ANGPT1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLLUAD,LUSC | |
| Reference showing the relevant tissue of ANGPT1 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0001936 | regulation of endothelial cell proliferation | 8980223 | GO:0002040 | sprouting angiogenesis | 10218485 | GO:0002092 | positive regulation of receptor internalization | 19424712 | GO:0007162 | negative regulation of cell adhesion | 19674970 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 19424712 | GO:0010595 | positive regulation of endothelial cell migration | 12958144 | GO:0014842 | regulation of satellite cell proliferation | 19733541 | GO:0030210 | heparin biosynthetic process | 19297368 | GO:0031398 | positive regulation of protein ubiquitination | 19689429 | GO:0034394 | protein localization to cell surface | 19615361 | GO:0043066 | negative regulation of apoptotic process | 10218485 | GO:0043116 | negative regulation of vascular permeability | 14978158 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 9660821 | GO:0048014 | Tie signaling pathway | 19689429 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15851516 | GO:0050918 | positive chemotaxis | 9660821 | GO:0051897 | positive regulation of protein kinase B signaling | 18425120 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18425120 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 19674970 | GO:0001936 | regulation of endothelial cell proliferation | 8980223 | GO:0002040 | sprouting angiogenesis | 10218485 | GO:0002092 | positive regulation of receptor internalization | 19424712 | GO:0007162 | negative regulation of cell adhesion | 19674970 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 19424712 | GO:0010595 | positive regulation of endothelial cell migration | 12958144 | GO:0014842 | regulation of satellite cell proliferation | 19733541 | GO:0030210 | heparin biosynthetic process | 19297368 | GO:0031398 | positive regulation of protein ubiquitination | 19689429 | GO:0034394 | protein localization to cell surface | 19615361 | GO:0043066 | negative regulation of apoptotic process | 10218485 | GO:0043116 | negative regulation of vascular permeability | 14978158 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 9660821 | GO:0048014 | Tie signaling pathway | 19689429 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15851516 | GO:0050918 | positive chemotaxis | 9660821 | GO:0051897 | positive regulation of protein kinase B signaling | 18425120 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18425120 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 19674970 |
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| TissGeneExp for ANGPT1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.06066337 | 3.434643762 | -3.373980392 | 5.25E-21 | 7.21E-20 |
| KICH | 3.617445487 | 1.817149487 | 1.800296 | 1.38E-05 | 4.25E-05 |
| KIRC | 0.985346376 | 2.063176932 | -1.077830556 | 1.09E-10 | 3.87E-10 |
| LUAD | 0.747533349 | 3.333664384 | -2.586131034 | 1.83E-19 | 3.36E-18 |
| PRAD | 1.19411518 | 3.064501718 | -1.870386538 | 1.54E-16 | 3.01E-14 |
| BRCA | -0.777185495 | 2.004092575 | -2.78127807 | 8.83E-40 | 2.58E-38 |
| KIRP | -1.683886263 | 1.690344987 | -3.37423125 | 9.34E-14 | 1.86E-12 |
| BLCA | -1.235600407 | 0.573410119 | -1.809010526 | 0.000331 | 0.002944576 |
| STAD | -0.490620638 | 0.917657487 | -1.408278125 | 8.91E-05 | 0.000690986 |
| COAD | -0.975723282 | 0.232022872 | -1.207746154 | 0.000102 | 0.000369392 |
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| TissGene-miRNA for ANGPT1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ANGPT1 |
| TissGeneSNV for ANGPT1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G75E | SKCM | 5 |
| p.G275E | SKCM | 3 |
| p.M291I | SKCM | 2 |
| p.M292I | SKCM | 2 |
| p.R130C | SKCM | 2 |
| p.G213E | SKCM | 2 |
| p.G195E | SKCM | 2 |
| p.T27P | ESCA | 1 |
| p.N472D | STAD | 1 |
| p.E101K | READ | 1 |
| p.P48S | SKCM | 1 |
| p.Q117H | BRCA | 1 |
| p.Q36R | SKCM | 1 |
| p.M107T | LUAD | 1 |
| p.G158E | SKCM | 1 |
| p.R402S | SKCM | 1 |
| p.Q137E | BRCA | 1 |
| p.G395R | SKCM | 1 |
| p.E129K | SKCM | 1 |
| p.A364V | STAD | 1 |
| p.L47I | THYM | 1 |
| p.E78D | HNSC | 1 |
| p.E79K | SKCM | 1 |
| p.H477Y | STAD | 1 |
| p.R158Q | UCEC | 1 |
| p.R384X | ESCA | 1 |
| p.G131E | SKCM | 1 |
| p.F78L | CESC | 1 |
| p.W248* | SKCM | 1 |
| p.G358E | SKCM | 1 |
| p.R287H | HNSC | 1 |
| p.G274V | CHOL | 1 |
| p.E143K | SKCM | 1 |
| p.R130H | BLCA | 1 |
| p.E174D | LIHC | 1 |
| p.E183K | SKCM | 1 |
| p.P454S | SKCM | 1 |
| p.M346I | STAD | 1 |
| p.E8K | SKCM | 1 |
| p.S297R | LUAD | 1 |
| p.S285F | SKCM | 1 |
| p.S29T | HNSC | 1 |
| p.R225C | UCEC | 1 |
| p.G265E | SKCM | 1 |
| p.Q368R | ESCA | 1 |
| p.M307T | LUAD | 1 |
| p.N92T | COAD | 1 |
| p.K216N | STAD | 1 |
| p.R184* | ESCA | 1 |
| p.E343X | SKCM | 1 |
| p.D297V | ESCA | 1 |
| p.G323V | LUAD | 1 |
| p.G269E | SKCM | 1 |
| p.D224N | SKCM | 1 |
| p.E101D | UCS | 1 |
| p.T124K | ESCA | 1 |
| p.D56E | LUAD | 1 |
| p.G453S | SKCM | 1 |
| p.F337L | UCEC | 1 |
| p.S485F | SKCM | 1 |
| p.L264F | SKCM | 1 |
| p.T101I | SKCM | 1 |
| p.D497V | ESCA | 1 |
| p.E253K | LUSC | 1 |
| p.I36M | KIRP | 1 |
| p.K342N | COAD | 1 |
| p.T209N | LUAD | 1 |
| p.T325A | STAD | 1 |
| p.G465R | LUAD | 1 |
| p.N116K | LUAD | 1 |
| p.E183X | STAD | 1 |
| p.Q91K | LUAD | 1 |
| p.D433G | SKCM | 1 |
| p.L261F | SKCM | 1 |
| p.T132A | STAD | 1 |
| p.P295L | SKCM | 1 |
| p.R84K | SKCM | 1 |
| p.L219I | UCEC | 1 |
| p.Q31* | SKCM | 1 |
| p.E381K | READ | 1 |
| p.A464V | UCEC | 1 |
| p.Q37K | KIRP | 1 |
| p.A440D | ESCA | 1 |
| p.L64F | SKCM | 1 |
| p.F192V | LGG | 1 |
| p.E143* | SKCM | 1 |
| p.A164V | STAD | 1 |
| p.E397G | STAD | 1 |
| p.G75R | SKCM | 1 |
| p.R384Q | UCEC | 1 |
| p.Q84* | BLCA | 1 |
| p.E234G | SKCM | 1 |
| p.G74V | CHOL | 1 |
| p.L159P | OV | 1 |
| p.G358W | LIHC | 1 |
| p.S110L | UCEC | 1 |
| p.W448X | SKCM | 1 |
| p.N316K | LUAD | 1 |
| p.S133N | SKCM | 1 |
| p.Q114H | UCEC | 1 |
| p.R487H | COAD | 1 |
| p.E78K | SKCM | 1 |
| p.L264V | BRCA | 1 |
| p.G395E | SKCM | 1 |
| p.L177R | ESCA | 1 |
| p.R284K | SKCM | 1 |
| p.T15A | STAD | 1 |
| p.G469E | SKCM | 1 |
| p.R294Q | LUAD | 1 |
| p.N200K | LGG | 1 |
| p.K312T | STAD | 1 |
| p.R487H | HNSC | 1 |
| p.Q236R | SKCM | 1 |
| p.E34G | SKCM | 1 |
| p.E14K | SKCM | 1 |
| p.P495L | SKCM | 1 |
| p.T126A | STAD | 1 |
| p.R191K | SKCM | 1 |
| p.Q84X | ESCA | 1 |
| p.I130L | COAD | 1 |
| p.T301I | SKCM | 1 |
| p.E34K | SKCM | 1 |
| p.R277I | LIHC | 1 |
| p.G253S | SKCM | 1 |
| p.D424N | SKCM | 1 |
| p.G21S | SKCM | 1 |
| p.K109T | ESCA | 1 |
| p.G347V | BRCA | 1 |
| p.R330C | SKCM | 1 |
| p.G221S | SKCM | 1 |
| p.Q37K | READ | 1 |
| p.D233G | SKCM | 1 |
| p.E160K | SKCM | 1 |
| p.Q168R | ESCA | 1 |
| p.T227P | ESCA | 1 |
| p.S97R | LUAD | 1 |
| p.G265R | LUAD | 1 |
| p.Q179* | LUAD | 1 |
| p.G149E | SKCM | 1 |
| p.I299T | COAD | 1 |
| p.P254S | SKCM | 1 |
| p.T101S | LUAD | 1 |
| p.G123V | LUAD | 1 |
| p.E234K | SKCM | 1 |
| p.L271S | READ | 1 |
| p.L61F | SKCM | 1 |
| p.R494Q | LUAD | 1 |
| p.N383K | LIHC | 1 |
| p.M491I | SKCM | 1 |
| p.L335I | HNSC | 1 |
| p.G195R | SKCM | 1 |
| p.L194F | LIHC | 1 |
| p.D256G | GBM | 1 |
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| TissGeneCNV for ANGPT1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ANGPT1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW119175 | ANGPT1-HIP1 | chr8:108348501 | chr7:75190630 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12P-01A | ZFP41-ANGPT1 | 3UTR-CDS | Chr8:144333510 | Chr8:108334356 |
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| TissGeneNet for ANGPT1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| COAD (tumor) | COAD (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| KICH (tumor) | KICH (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| STAD (tumor) | STAD (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| THCA (tumor) | THCA (normal) |
| ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (tumor) | ANGPT1, TEK, ELF3, ITGA5, ANGPT2 (normal) |
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| TissGeneProg for ANGPT1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ANGPT1 |
| TissGeneDrug for ANGPT1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ANGPT1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1519670 | Tumor Angiogenesis | 15 | BeFree |
| umls:C2239176 | Liver carcinoma | 10 | BeFree,LHGDN |
| umls:C0022116 | Ischemia | 8 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 7 | BeFree,LHGDN,RGD |
| umls:C0003873 | Rheumatoid Arthritis | 6 | BeFree |
| umls:C0027051 | Myocardial Infarction | 6 | BeFree,RGD |
| umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 6 | BeFree,GAD,RGD |
| umls:C0003850 | Arteriosclerosis | 5 | BeFree |
| umls:C0004114 | Astrocytoma | 5 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 5 | BeFree |
| umls:C0699790 | Colon Carcinoma | 5 | BeFree |
| umls:C0004153 | Atherosclerosis | 4 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
| umls:C0017636 | Glioblastoma | 4 | BeFree,LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 4 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 4 | BeFree,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree |
| umls:C0243026 | Sepsis | 4 | BeFree,CTD_human,LHGDN |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0684249 | Carcinoma of lung | 4 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
| umls:C0740391 | Middle Cerebral Artery Occlusion | 4 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 4 | BeFree |
| umls:C0003864 | Arthritis | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0007785 | Cerebral Infarction | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
| umls:C0016059 | Fibrosis | 3 | CTD_human,LHGDN |
| umls:C0017638 | Glioma | 3 | BeFree |
| umls:C0022658 | Kidney Diseases | 3 | BeFree |
| umls:C0026764 | Multiple Myeloma | 3 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 3 | BeFree |
| umls:C0006118 | Brain Neoplasms | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | RGD |
| umls:C0014175 | Endometriosis | 2 | BeFree,LHGDN |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree,LHGDN |
| umls:C0018802 | Congestive heart failure | 2 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree,GAD |
| umls:C0023895 | Liver diseases | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree |
| umls:C0036690 | Septicemia | 2 | BeFree |
| umls:C0042373 | Vascular Diseases | 2 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
| umls:C0333980 | Focal Nodular Hyperplasia | 2 | BeFree,LHGDN |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0598766 | Leukemogenesis | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C1290884 | Inflammatory disorder | 2 | BeFree |
| umls:C1514422 | Primary Glioblastoma | 2 | BeFree |
| umls:C1704436 | Peripheral Arterial Diseases | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0001339 | Acute pancreatitis | 1 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree,LHGDN |
| umls:C0002793 | Anaplasia | 1 | BeFree |
| umls:C0002940 | Aneurysm | 1 | BeFree |
| umls:C0003130 | Anoxia | 1 | LHGDN |
| umls:C0004096 | Asthma | 1 | LHGDN |
| umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
| umls:C0005411 | Biliary Atresia | 1 | BeFree |
| umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
| umls:C0006111 | Brain Diseases | 1 | GAD |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0007766 | Intracranial Aneurysm | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0008354 | Cholera | 1 | BeFree |
| umls:C0008479 | Chondrosarcoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0013537 | Eclampsia | 1 | BeFree |
| umls:C0017667 | Nodular glomerulosclerosis | 1 | BeFree |
| umls:C0018021 | Goiter | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018916 | Hemangioma | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | CTD_human |
| umls:C0023267 | Fibroid Tumor | 1 | LHGDN |
| umls:C0023462 | Acute Megakaryocytic Leukemias | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | RGD |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 1 | BeFree |
| umls:C0026850 | Muscular Dystrophy | 1 | BeFree |
| umls:C0027626 | Neoplasm Invasiveness | 1 | RGD |
| umls:C0027686 | Pathologic Neovascularization | 1 | LHGDN |
| umls:C0027707 | Nephritis, Interstitial | 1 | BeFree |
| umls:C0027720 | Nephrosis | 1 | RGD |
| umls:C0027809 | Neurilemmoma | 1 | LHGDN |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | LHGDN |
| umls:C0032962 | Pregnancy Complications | 1 | BeFree |
| umls:C0032987 | Ectopic Pregnancy | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | BeFree |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0036983 | Septic Shock | 1 | LHGDN |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0038358 | Gastric ulcer | 1 | RGD |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | BeFree |
| umls:C0040038 | Thromboembolism | 1 | BeFree |
| umls:C0042164 | Uveitis | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0079774 | Peripheral T-Cell Lymphoma | 1 | BeFree |
| umls:C0085669 | Acute leukemia | 1 | BeFree |
| umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0206733 | Strawberry nevus of skin | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0235833 | Congenital diaphragmatic hernia | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | LHGDN |
| umls:C0242350 | Erectile dysfunction | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C0242723 | Parasitemia | 1 | BeFree |
| umls:C0264694 | Chronic myocardial ischemia | 1 | BeFree |
| umls:C0278619 | Extramedullary Plasmacytoma | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0339543 | Epiretinal Membrane | 1 | BeFree |
| umls:C0341439 | Chronic liver disease | 1 | BeFree |
| umls:C0346153 | Breast Cancer, Familial | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0349782 | Ischemic cardiomyopathy | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0747845 | early pregnancy | 1 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
| umls:C0850803 | Anaphylaxis (non medication) | 1 | BeFree |
| umls:C0947751 | Vascular inflammations | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C0948249 | Femoral artery occlusion | 1 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C0971858 | Arthritis, Collagen-Induced | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1314694 | Astrocytoma, low grade | 1 | BeFree |
| umls:C1336527 | Carcinoma of urinary bladder, superficial | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1510885 | Angiogenic Switch | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1658953 | tumor vasculature | 1 | BeFree |
| umls:C1868851 | Pulmonary arterial hypertension associated with portal hypertension | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | LHGDN |
| umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
| umls:C3714757 | Juvenile rheumatoid arthritis | 1 | BeFree |
| umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |
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