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| TissGeneSummary for SLC13A5 |
 Gene summary |
| Basic gene information | Gene symbol | SLC13A5 |
| Gene name | solute carrier family 13 (sodium-dependent citrate transporter), member 5 | |
| Synonyms | EIEE25|NACT|mIndy | |
| Cytomap | UCSC genome browser: 17p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001143838.2, NM_001284509.1,NM_001284510.1,NM_177550.4, | |
| Description | Na(+)/citrate cotransporterNa+-coupled citrate transporter proteinsodium-dependent dicarboxylate transportersolute carrier family 13 member 5 | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 608305 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000141485 | ||
| HPRD : 10512 | ||
| Vega : OTTHUMG00000102052 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC13A5 | |
| BioGPS: 284111 | ||
| Pathway | NCI Pathway Interaction Database: SLC13A5 | |
| KEGG: SLC13A5 | ||
| REACTOME: SLC13A5 | ||
| Pathway Commons: SLC13A5 | ||
| Context | iHOP: SLC13A5 | |
| ligand binding site mutation search in PubMed: SLC13A5 | ||
| UCL Cancer Institute: SLC13A5 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SLC13A5 | Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice. Brachs S, Winkel AF, Tang H, Birkenfeld AL, Brunner B, Jahn-Hofmann K, Margerie D, Ruetten H, Schmoll D, Spranger J. Mol Metab. 2016 Aug 13;5(11):1072-1082. eCollection 2016 Nov (pmid:27818933) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC13A5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -2.546245395 | -0.972439839 | -1.573805556 | 2.84E-08 | 8.25E-08 |
| BRCA | -2.014327632 | -0.463303948 | -1.551023684 | 8.65E-22 | 7.06E-21 |
| LIHC | 8.200705105 | 10.5007931 | -2.300088 | 1.33E-06 | 6.97E-06 |
| LUSC | 0.846466125 | -1.86774564 | 2.714211765 | 9.01E-09 | 2.86E-08 |
| KICH | -3.070274895 | -1.072510895 | -1.997764 | 8.75E-06 | 2.80E-05 |
| KIRP | -2.870626645 | -0.79847352 | -2.072153125 | 5.26E-06 | 2.30E-05 |
| LUAD | -1.13014324 | -2.172615654 | 1.042472414 | 0.000509 | 0.001159073 |
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| TissGene-miRNA for SLC13A5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC13A5 |
| TissGeneSNV for SLC13A5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q273P | GBM | 2 |
| p.R308H | UCEC | 1 |
| p.K292N | UCEC | 1 |
| p.T468I | SKCM | 1 |
| p.S355F | SKCM | 1 |
| p.W346R | STAD | 1 |
| p.V537F | UCEC | 1 |
| p.T221I | SKCM | 1 |
| p.E305K | CHOL | 1 |
| p.A110T | UCEC | 1 |
| p.X523S | SKCM | 1 |
| p.H556Y | SKCM | 1 |
| p.A222T | BRCA | 1 |
| p.I212V | STAD | 1 |
| p.G228R | SKCM | 1 |
| p.A446S | LUAD | 1 |
| p.A216T | SARC | 1 |
| p.Q158K | STAD | 1 |
| p.R308H | BRCA | 1 |
| p.E305K | UCEC | 1 |
| p.F538L | UCEC | 1 |
| p.T449A | UCEC | 1 |
| p.E239K | HNSC | 1 |
| p.L234M | SKCM | 1 |
| p.W271* | SKCM | 1 |
| p.Y214X | KICH | 1 |
| p.I151N | STAD | 1 |
| p.A268S | LUAD | 1 |
| p.K374N | PAAD | 1 |
| p.V19I | UCEC | 1 |
| p.P259S | SKCM | 1 |
| p.P371S | LUAD | 1 |
| p.A523T | STAD | 1 |
| p.D398N | SKCM | 1 |
| p.L210M | SARC | 1 |
| p.G286D | SKCM | 1 |
| p.E305D | HNSC | 1 |
| p.K202N | LGG | 1 |
| p.N249S | COAD | 1 |
| p.T225P | KIRP | 1 |
| p.P505S | LUAD | 1 |
| p.A39P | LUAD | 1 |
| p.L44F | LUAD | 1 |
| p.Y214* | KICH | 1 |
| p.F279Y | BLCA | 1 |
| p.K120N | HNSC | 1 |
| p.A360V | PRAD | 1 |
| p.R201W | STAD | 1 |
| p.E567Q | CESC | 1 |
| p.G226R | STAD | 1 |
| p.V456I | COAD | 1 |
| p.A207D | STAD | 1 |
| p.M45K | LUAD | 1 |
| p.W560* | BLCA | 1 |
| p.L105V | BLCA | 1 |
| p.P150L | SKCM | 1 |
| p.G190S | BLCA | 1 |
| p.E461Q | CESC | 1 |
| p.S430F | UCEC | 1 |
| p.T209A | STAD | 1 |
| p.A550T | PCPG | 1 |
| p.M479I | HNSC | 1 |
| p.E197K | SKCM | 1 |
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| TissGeneCNV for SLC13A5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC13A5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC13A5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC13A5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC13A5 |
| TissGeneDrug for SLC13A5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC13A5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0543888 | Epileptic encephalopathy | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0015695 | Fatty Liver | 1 | BeFree,CTD_human |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
| umls:C0393706 | Early infantile epileptic encephalopathy with suppression bursts | 0 | ORPHANET |
| umls:C1959629 | Seizure Adverse Event | 0 | CLINVAR |
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