TissGeneSummary for IZUMO1 |
Gene summary |
Basic gene information | Gene symbol | IZUMO1 |
Gene name | izumo sperm-egg fusion 1 | |
Synonyms | IZUMO | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_182575.2, | |
Description | OBFizumo sperm-egg fusion protein 1oocyte binding/fusion factorsperm-specific protein Izumo | |
Modification date | 20141207 | |
dbXrefs | MIM : 609278 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182264 | ||
HPRD : 14589 | ||
Vega : OTTHUMG00000183324 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IZUMO1 | |
BioGPS: 284359 | ||
Pathway | NCI Pathway Interaction Database: IZUMO1 | |
KEGG: IZUMO1 | ||
REACTOME: IZUMO1 | ||
Pathway Commons: IZUMO1 | ||
Context | iHOP: IZUMO1 | |
ligand binding site mutation search in PubMed: IZUMO1 | ||
UCL Cancer Institute: IZUMO1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of IZUMO1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007342 | fusion of sperm to egg plasma membrane | 15759005 | GO:0007342 | fusion of sperm to egg plasma membrane | 15759005 |
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TissGeneExp for IZUMO1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
ESCA | -0.021083192 | 1.492862263 | -1.513945455 | 0.00246 | 0.025314654 |
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TissGene-miRNA for IZUMO1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IZUMO1 |
TissGeneSNV for IZUMO1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V250I | LUAD | 1 |
p.Q188P | SKCM | 1 |
p.A243V | STAD | 1 |
p.E80K | LUAD | 1 |
p.A272E | LUAD | 1 |
p.H249L | LUAD | 1 |
p.D63N | LUAD | 1 |
p.E55K | SKCM | 1 |
p.R96C | PAAD | 1 |
p.D101N | CESC | 1 |
p.K109N | COAD | 1 |
p.I179M | PAAD | 1 |
p.D105N | SKCM | 1 |
p.S240C | PAAD | 1 |
p.R128Q | SKCM | 1 |
p.R315Q | LIHC | 1 |
p.H50Y | SKCM | 1 |
p.R128Q | READ | 1 |
p.E37X | KIRC | 1 |
p.S162Y | KIRC | 1 |
p.D101N | SKCM | 1 |
p.E183A | DLBC | 1 |
p.Q338K | ESCA | 1 |
p.R56M | BLCA | 1 |
p.N185K | UCEC | 1 |
p.M288T | UCEC | 1 |
p.N137S | STAD | 1 |
p.R314C | BLCA | 1 |
p.M75T | ESCA | 1 |
p.A189V | UCEC | 1 |
p.D320N | DLBC | 1 |
p.T6S | LUAD | 1 |
p.E80V | PRAD | 1 |
p.R232H | OV | 1 |
p.P27S | SKCM | 1 |
p.V61M | UCEC | 1 |
p.S276P | LIHC | 1 |
p.P282T | STAD | 1 |
p.I319T | UCEC | 1 |
p.E275V | HNSC | 1 |
p.R160* | LUAD | 1 |
p.F198L | STAD | 1 |
p.L31M | LGG | 1 |
p.V250I | HNSC | 1 |
p.R168Q | HNSC | 1 |
p.K85R | TGCT | 1 |
p.E286K | THYM | 1 |
p.D320N | PRAD | 1 |
p.A52V | SKCM | 1 |
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TissGeneCNV for IZUMO1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IZUMO1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI045770 | IZUMO1-MYADM | chr19:49245404 | chr19:54376851 |
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TissGeneNet for IZUMO1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IZUMO1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IZUMO1 |
TissGeneDrug for IZUMO1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IZUMO1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021364 | Male infertility | 1 | GAD |
umls:C0028960 | Oligospermia | 1 | BeFree |
umls:C0332915 | Congenital failure of fusion | 1 | BeFree |