TissGeneSummary for WDR62 |
Gene summary |
Basic gene information | Gene symbol | WDR62 |
Gene name | WD repeat domain 62 | |
Synonyms | C19orf14|MCPH2 | |
Cytomap | UCSC genome browser: 19q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001083961.1, NM_173636.4, | |
Description | WD repeat-containing protein 62microcephaly, primary autosomal recessive 2 | |
Modification date | 20141219 | |
dbXrefs | MIM : 613583 | |
HGNC : HGNC | ||
Ensembl : ENSG00000075702 | ||
HPRD : 10721 | ||
Vega : OTTHUMG00000048139 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR62 | |
BioGPS: 284403 | ||
Pathway | NCI Pathway Interaction Database: WDR62 | |
KEGG: WDR62 | ||
REACTOME: WDR62 | ||
Pathway Commons: WDR62 | ||
Context | iHOP: WDR62 | |
ligand binding site mutation search in PubMed: WDR62 | ||
UCL Cancer Institute: WDR62 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of WDR62 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for WDR62 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.609753145 | -0.493776267 | 3.103529412 | 1.42E-32 | 9.99E-31 |
KIRC | -1.041956169 | -2.300340891 | 1.258384722 | 1.72E-13 | 7.82E-13 |
LIHC | 0.891005497 | -1.522816503 | 2.413822 | 9.54E-20 | 5.73E-18 |
STAD | 2.470654247 | -0.292958253 | 2.7636125 | 3.15E-11 | 4.62E-09 |
LUAD | 1.369337222 | -0.796557606 | 2.165894828 | 3.29E-17 | 4.17E-16 |
KIRP | -0.227786378 | -1.621908253 | 1.394121875 | 6.36E-07 | 3.40E-06 |
BRCA | 1.453695147 | -1.415503976 | 2.869199123 | 6.51E-43 | 2.49E-41 |
COAD | 2.292873959 | 0.328250882 | 1.964623077 | 1.03E-10 | 1.47E-09 |
ESCA | 3.020780952 | -0.418755412 | 3.439536364 | 0.000404 | 0.008168145 |
BLCA | 2.255693392 | -0.524511871 | 2.780205263 | 7.42E-06 | 0.000151395 |
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TissGene-miRNA for WDR62 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WDR62 |
TissGeneSNV for WDR62 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H519Y | SKCM | 2 |
p.D525Y | LUAD | 1 |
p.L96W | HNSC | 1 |
p.K1155N | STAD | 1 |
p.K984M | LIHC | 1 |
p.R825C | LUAD | 1 |
p.Q574H | LUAD | 1 |
p.D1433H | CESC | 1 |
p.R1345H | STAD | 1 |
p.A1497T | UCEC | 1 |
p.R512Q | READ | 1 |
p.C91W | BLCA | 1 |
p.E1089K | BLCA | 1 |
p.R1169C | PRAD | 1 |
p.N457S | SKCM | 1 |
p.E526K | READ | 1 |
p.P988S | SKCM | 1 |
p.T430I | HNSC | 1 |
p.V1242M | UCEC | 1 |
p.V1513L | STAD | 1 |
p.S914A | COAD | 1 |
p.P1119S | CESC | 1 |
p.L337F | SKCM | 1 |
p.K452I | LGG | 1 |
p.I308V | BLCA | 1 |
p.R863C | STAD | 1 |
p.A149V | COAD | 1 |
p.Y464X | ESCA | 1 |
p.E1089K | HNSC | 1 |
p.V699M | TGCT | 1 |
p.V142G | SKCM | 1 |
p.R438L | PAAD | 1 |
p.A1510V | STAD | 1 |
p.K771R | DLBC | 1 |
p.G494E | KIRC | 1 |
p.E1084K | HNSC | 1 |
p.P1408S | COAD | 1 |
p.T768A | STAD | 1 |
p.C312F | THYM | 1 |
p.F523C | MESO | 1 |
p.E484K | BLCA | 1 |
p.S675F | READ | 1 |
p.R608H | STAD | 1 |
p.R557Q | SKCM | 1 |
p.R773Q | HNSC | 1 |
p.S427F | BLCA | 1 |
p.D800N | LUAD | 1 |
p.K1160N | STAD | 1 |
p.A1157S | COAD | 1 |
p.P1491L | STAD | 1 |
p.V191I | STAD | 1 |
p.R922C | UCEC | 1 |
p.T1176M | LUSC | 1 |
p.W186L | LUAD | 1 |
p.S704L | KIRP | 1 |
p.A1004T | KICH | 1 |
p.P1351A | HNSC | 1 |
p.G1473R | UCEC | 1 |
p.E231G | STAD | 1 |
p.G1375S | COAD | 1 |
p.S172F | SKCM | 1 |
p.V1508L | STAD | 1 |
p.A116V | STAD | 1 |
p.K855N | LUAD | 1 |
p.P1488Q | THYM | 1 |
p.P860A | CESC | 1 |
p.D1314N | CESC | 1 |
p.S375T | STAD | 1 |
p.S207L | BLCA | 1 |
p.P1054S | KIRC | 1 |
p.P414S | SKCM | 1 |
p.E231K | THYM | 1 |
p.S696N | LIHC | 1 |
p.A854V | COAD | 1 |
p.K354N | UCEC | 1 |
p.A159E | HNSC | 1 |
p.G1235S | SKCM | 1 |
p.S1233F | SKCM | 1 |
p.E288* | THCA | 1 |
p.D314N | HNSC | 1 |
p.E892K | THYM | 1 |
p.R1294Q | STAD | 1 |
p.R1436C | UCEC | 1 |
p.S987N | UCEC | 1 |
p.Q1316E | DLBC | 1 |
p.R856H | PAAD | 1 |
p.R773W | STAD | 1 |
p.C692Y | STAD | 1 |
p.S382I | UCEC | 1 |
p.R1431C | STAD | 1 |
p.K461N | UCEC | 1 |
p.G338W | LUAD | 1 |
p.Q880R | BLCA | 1 |
p.G966R | BLCA | 1 |
p.G1289D | UCEC | 1 |
p.P239S | UCEC | 1 |
p.V1237M | STAD | 1 |
p.A1266V | STAD | 1 |
p.S1415G | UCEC | 1 |
p.S1049F | SKCM | 1 |
p.P36S | BLCA | 1 |
p.L337V | ESCA | 1 |
p.P479L | SKCM | 1 |
p.E892K | UCEC | 1 |
p.A1479T | COAD | 1 |
p.A342S | LUAD | 1 |
p.G923R | UCS | 1 |
p.P1486L | STAD | 1 |
p.R1225H | DLBC | 1 |
p.R1018Q | UCEC | 1 |
p.E288X | THCA | 1 |
p.G795R | BLCA | 1 |
p.R608C | COAD | 1 |
p.S456I | THYM | 1 |
p.Q1310L | COAD | 1 |
p.G75V | LUSC | 1 |
p.E1084K | BLCA | 1 |
p.G795E | BRCA | 1 |
p.P888S | LGG | 1 |
p.I170V | PRAD | 1 |
p.S734F | SKCM | 1 |
p.G276A | STAD | 1 |
p.R243C | UCEC | 1 |
p.P360L | THYM | 1 |
p.Y464* | ESCA | 1 |
p.S704L | PRAD | 1 |
p.Q611L | LUAD | 1 |
p.P1346A | HNSC | 1 |
p.R1289Q | STAD | 1 |
p.R47* | LUSC | 1 |
p.E915K | BLCA | 1 |
p.P1408L | SKCM | 1 |
p.D1191G | BLCA | 1 |
p.R825C | SKCM | 1 |
p.P488R | ACC | 1 |
p.V679G | BRCA | 1 |
p.R1436C | STAD | 1 |
p.A1179T | BLCA | 1 |
p.L1285M | PRAD | 1 |
p.E400K | LUAD | 1 |
p.S581F | SKCM | 1 |
p.G1138R | OV | 1 |
p.R608C | UCEC | 1 |
p.E1333X | STAD | 1 |
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TissGeneCNV for WDR62 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WDR62 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF118081 | H19-WDR62 | chr11:2019035 | chr19:36561143 | |
Chimerdb3.0 | ChiTaRs | NA | BF800113 | WDR62-CCND2 | chr19:36593629 | chr12:4411492 | |
Chimerdb3.0 | FusionScan | COAD | TCGA-G4-6299-01A | WDR62-TBCB | Out-of-Frame | chr19:36550932 | chr19:36616352 |
Chimerdb3.0 | TopHat-Fusion | BLCA | TCGA-BT-A3PH-01A | WDR62-HCST | In-Frame | chr19:36575645 | chr19:36394252 |
TCGAfusionPortal | PRADA | BLCA | TCGA-BT-A3PH-01A | WDR62-HCST | In-frame | Chr19:36575646 | Chr19:36394253 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AI-01A | WDR62-AC002511.1 | CDS-5UTR | Chr19:36550932 | Chr19:35897487 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1F6-01A | THAP8-WDR62 | Out-of-frame | Chr19:36545037 | Chr19:36549682 |
TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-A46G-01A | SIPA1L3-WDR62 | Out-of-frame | Chr19:38643607 | Chr19:36549682 |
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TissGeneNet for WDR62 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WDR62 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WDR62 |
TissGeneDrug for WDR62 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WDR62 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C3711387 | Autosomal Recessive Primary Microcephaly | 9 | BeFree |
umls:C0025958 | Microcephaly | 7 | BeFree,CTD_human |
umls:C0431350 | Primary microcephaly | 5 | BeFree |
umls:C0266449 | Congenital anomaly of brain | 4 | BeFree |
umls:C1858535 | MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 2 (disorder) | 3 | CLINVAR,UNIPROT |
umls:C0000768 | Congenital Abnormality | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0026106 | Mild Mental Retardation | 1 | BeFree |
umls:C0342793 | Malonic aciduria | 1 | BeFree |
umls:C0344482 | Hypoplasia of corpus callosum | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C1535926 | Neurodevelopmental Disorders | 1 | BeFree |
umls:C1636149 | Macular dystrophy, corneal type 1 | 1 | BeFree |
umls:C1956147 | Microlissencephaly | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | CTD_human |
umls:C1838491 | Kuzniecky syndrome | 0 | CTD_human |