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| TissGeneSummary for NWD1 |
 Gene summary |
| Basic gene information | Gene symbol | NWD1 |
| Gene name | NACHT and WD repeat domain containing 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 19p13.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001007525.3, NM_001290355.1, | |
| Description | NACHT and WD repeat domain-containing protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000188039 | ||
| HPRD : 17337 | ||
| Vega : OTTHUMG00000164507 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NWD1 | |
| BioGPS: 284434 | ||
| Pathway | NCI Pathway Interaction Database: NWD1 | |
| KEGG: NWD1 | ||
| REACTOME: NWD1 | ||
| Pathway Commons: NWD1 | ||
| Context | iHOP: NWD1 | |
| ligand binding site mutation search in PubMed: NWD1 | ||
| UCL Cancer Institute: NWD1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of NWD1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NWD1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.641266323 | 2.528577745 | -4.169844068 | 7.02E-24 | 7.06E-22 |
| PRAD | 6.000127386 | 4.838612001 | 1.161515385 | 2.31E-11 | 6.47E-10 |
| BRCA | -1.114643026 | 0.031385922 | -1.146028947 | 1.29E-06 | 3.49E-06 |
| LUSC | -0.78351511 | 1.801322145 | -2.584837255 | 7.01E-08 | 2.01E-07 |
| KIRC | -0.972430306 | 0.133714138 | -1.106144444 | 7.47E-06 | 1.77E-05 |
| LUAD | -0.213815651 | 1.831848142 | -2.045663793 | 5.48E-06 | 1.65E-05 |
| KICH | -0.992605306 | 0.354174694 | -1.34678 | 0.0127 | 0.022356869 |
| STAD | -1.059995931 | -0.037164681 | -1.02283125 | 0.00588 | 0.022225412 |
| HNSC | -1.251065771 | 0.335936554 | -1.587002326 | 0.00225 | 0.006831984 |
| KIRP | -1.315411556 | 0.189694694 | -1.50510625 | 0.000679 | 0.001949191 |
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| TissGene-miRNA for NWD1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NWD1 |
| TissGeneSNV for NWD1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S757F | SKCM | 5 |
| p.D950N | SKCM | 2 |
| p.T1272M | COAD | 2 |
| p.W1422* | SKCM | 2 |
| p.S1147F | SKCM | 2 |
| p.G1032E | SKCM | 2 |
| p.Q333R | SARC | 1 |
| p.R592W | UCEC | 1 |
| p.R645W | UCEC | 1 |
| p.S720L | SKCM | 1 |
| p.R667H | COAD | 1 |
| p.H123D | BRCA | 1 |
| p.G323E | SKCM | 1 |
| p.W718L | THYM | 1 |
| p.L227R | UCEC | 1 |
| p.E1248K | SKCM | 1 |
| p.D485Y | READ | 1 |
| p.E748X | COAD | 1 |
| p.S1193A | LUSC | 1 |
| p.T1218S | LUSC | 1 |
| p.P956S | SKCM | 1 |
| p.P533T | LUSC | 1 |
| p.P452L | SKCM | 1 |
| p.R513K | SKCM | 1 |
| p.R1320H | UCEC | 1 |
| p.I765M | SKCM | 1 |
| p.S1074F | SKCM | 1 |
| p.Q392X | SKCM | 1 |
| p.P533S | SKCM | 1 |
| p.S380* | LUSC | 1 |
| p.S1427G | LIHC | 1 |
| p.A292V | STAD | 1 |
| p.E1400K | SKCM | 1 |
| p.A404V | SKCM | 1 |
| p.F312I | SKCM | 1 |
| p.E1247K | CESC | 1 |
| p.A525V | SARC | 1 |
| p.W524R | UVM | 1 |
| p.A925T | READ | 1 |
| p.H738R | GBM | 1 |
| p.S1431F | SKCM | 1 |
| p.E622K | SKCM | 1 |
| p.E1349K | KIRP | 1 |
| p.R299C | STAD | 1 |
| p.E1159D | STAD | 1 |
| p.I1192M | OV | 1 |
| p.V518L | PRAD | 1 |
| p.L1282P | BRCA | 1 |
| p.L399P | LIHC | 1 |
| p.S1353N | SKCM | 1 |
| p.S1053A | PRAD | 1 |
| p.H935R | COAD | 1 |
| p.P1294S | SKCM | 1 |
| p.S1554* | CESC | 1 |
| p.E182K | SKCM | 1 |
| p.T411I | DLBC | 1 |
| p.S1286F | SKCM | 1 |
| p.A966T | UCEC | 1 |
| p.L566H | ACC | 1 |
| p.M1366R | SKCM | 1 |
| p.M378I | SKCM | 1 |
| p.L536M | LUAD | 1 |
| p.V187I | PAAD | 1 |
| p.R210Q | ACC | 1 |
| p.T1162I | SKCM | 1 |
| p.P777S | SKCM | 1 |
| p.S1419* | CESC | 1 |
| p.A509T | COAD | 1 |
| p.S1000F | HNSC | 1 |
| p.Q900E | COAD | 1 |
| p.D931Y | DLBC | 1 |
| p.Q405* | CESC | 1 |
| p.F946C | LUAD | 1 |
| p.G908R | HNSC | 1 |
| p.T1031M | ESCA | 1 |
| p.A925T | COAD | 1 |
| p.V475I | SKCM | 1 |
| p.P867S | UCEC | 1 |
| p.R759Q | STAD | 1 |
| p.D1124N | BLCA | 1 |
| p.V1279A | BLCA | 1 |
| p.V369I | DLBC | 1 |
| p.A893V | THYM | 1 |
| p.C1298R | UCEC | 1 |
| p.T1272M | UCEC | 1 |
| p.K1037E | ESCA | 1 |
| p.W802* | UCEC | 1 |
| p.A292V | COAD | 1 |
| p.R741L | LUAD | 1 |
| p.T1137M | UCEC | 1 |
| p.L1164P | BLCA | 1 |
| p.A1377E | LUSC | 1 |
| p.A1534V | STAD | 1 |
| p.D606Y | BLCA | 1 |
| p.T1272M | BLCA | 1 |
| p.R544Q | SKCM | 1 |
| p.P486L | LGG | 1 |
| p.A1410T | PRAD | 1 |
| p.R1267C | DLBC | 1 |
| p.A589V | UCEC | 1 |
| p.K917T | READ | 1 |
| p.Y1428* | SKCM | 1 |
| p.L701V | BLCA | 1 |
| p.R446P | PRAD | 1 |
| p.E1045K | SKCM | 1 |
| p.T186I | SKCM | 1 |
| p.L1148F | SKCM | 1 |
| p.R248H | GBM | 1 |
| p.D249N | HNSC | 1 |
| p.R1285H | UCEC | 1 |
| p.Q943H | SKCM | 1 |
| p.G1369R | SKCM | 1 |
| p.G184R | SKCM | 1 |
| p.R665H | PRAD | 1 |
| p.G1036R | UCEC | 1 |
| p.R1267C | THCA | 1 |
| p.T1133M | THCA | 1 |
| p.E182K | ACC | 1 |
| p.T514M | SARC | 1 |
| p.E944D | COAD | 1 |
| p.D1124N | SKCM | 1 |
| p.D329A | SKCM | 1 |
| p.R1179C | SKCM | 1 |
| p.L189F | SKCM | 1 |
| p.P1348L | SKCM | 1 |
| p.L964I | READ | 1 |
| p.G890D | LUAD | 1 |
| p.A1547V | PAAD | 1 |
| p.A1301T | BLCA | 1 |
| p.S1120T | UCEC | 1 |
| p.R243H | BLCA | 1 |
| p.T896M | BRCA | 1 |
| p.E991K | UCEC | 1 |
| p.T106S | OV | 1 |
| p.V338L | LUAD | 1 |
| p.E613G | UCEC | 1 |
| p.P1002S | SKCM | 1 |
| p.R1267H | SKCM | 1 |
| p.T1272M | READ | 1 |
| p.T1031M | LUAD | 1 |
| p.Q392* | SKCM | 1 |
| p.D1001V | SKCM | 1 |
| p.R1390X | COAD | 1 |
| p.R653H | UCEC | 1 |
| p.R1206L | LUAD | 1 |
| p.S927C | BLCA | 1 |
| p.P1490H | LUAD | 1 |
| p.I1232T | THCA | 1 |
| p.R625H | UCS | 1 |
| p.G751D | SKCM | 1 |
| p.P245L | SKCM | 1 |
| p.R1420H | STAD | 1 |
| p.T1272M | LIHC | 1 |
| p.D1001N | SKCM | 1 |
| p.L278F | HNSC | 1 |
| p.D114N | UCEC | 1 |
| p.R625H | CESC | 1 |
| p.R861Q | STAD | 1 |
| p.V187I | STAD | 1 |
| p.R449W | UVM | 1 |
| p.P342S | SKCM | 1 |
| p.L302F | SKCM | 1 |
| p.W1387* | BRCA | 1 |
| p.E1046K | SKCM | 1 |
| p.R1078K | SKCM | 1 |
| p.I1043M | HNSC | 1 |
| p.R1498Q | BLCA | 1 |
| p.Q1055K | LUAD | 1 |
| p.K1311N | UCEC | 1 |
| p.R510W | UCEC | 1 |
| p.R181Q | KICH | 1 |
| p.W1422X | SKCM | 1 |
| p.D477V | STAD | 1 |
| p.V462M | SKCM | 1 |
| p.V1227I | SKCM | 1 |
| p.D1331Y | SKCM | 1 |
| p.V1322I | STAD | 1 |
| p.R1363Q | UCEC | 1 |
| p.A842T | READ | 1 |
| p.Q183L | DLBC | 1 |
| p.G1486S | SKCM | 1 |
| p.L278F | SKCM | 1 |
| p.G997R | SKCM | 1 |
| p.E1551K | SKCM | 1 |
| p.L200F | SKCM | 1 |
| p.D931N | SKCM | 1 |
| p.R449W | SKCM | 1 |
| p.A1508S | SARC | 1 |
| p.H1039R | BLCA | 1 |
| p.G1181R | SKCM | 1 |
| p.G616R | BRCA | 1 |
| p.R1179H | ESCA | 1 |
| p.E561* | CESC | 1 |
| p.D1213G | STAD | 1 |
| p.A409V | SKCM | 1 |
| p.K819Q | UCEC | 1 |
| p.A212T | DLBC | 1 |
| p.P403S | SKCM | 1 |
| p.R1118C | SKCM | 1 |
| p.A724V | UCEC | 1 |
| p.V1008M | PCPG | 1 |
| p.A820T | GBM | 1 |
| p.R512K | SKCM | 1 |
| p.G1451C | LUAD | 1 |
| p.A1219T | STAD | 1 |
| p.P1230S | PAAD | 1 |
| p.R180H | UCEC | 1 |
| p.R1498L | LUAD | 1 |
| p.D1099G | UCEC | 1 |
| p.E170K | SKCM | 1 |
| p.P342L | SKCM | 1 |
| p.R315H | LGG | 1 |
| p.R315C | UCS | 1 |
| p.R741S | LUAD | 1 |
| p.E766K | CESC | 1 |
| p.D606A | SKCM | 1 |
| p.R282C | UCEC | 1 |
| p.S1306F | SKCM | 1 |
| p.S1308N | STAD | 1 |
| p.R665H | STAD | 1 |
| p.H1222N | THYM | 1 |
| p.P1283L | SKCM | 1 |
| p.R635C | SKCM | 1 |
| p.R1420H | UCEC | 1 |
| p.A580T | SKCM | 1 |
| p.G497R | HNSC | 1 |
| p.W631* | SKCM | 1 |
| p.L200I | STAD | 1 |
| p.R1420C | STAD | 1 |
| p.P824Q | ESCA | 1 |
| p.G266S | STAD | 1 |
| p.K676N | CESC | 1 |
| p.R449Q | SKCM | 1 |
| p.E542K | SKCM | 1 |
| p.P1383S | SKCM | 1 |
| p.A790V | SKCM | 1 |
| p.R667L | THYM | 1 |
| p.K902E | UCEC | 1 |
| p.R1179H | SKCM | 1 |
| p.E1168K | LUSC | 1 |
| p.D1444N | SKCM | 1 |
| p.E191K | SKCM | 1 |
| p.V1473F | LUAD | 1 |
| p.A1084T | UCEC | 1 |
| p.V1207M | SKCM | 1 |
| p.G344D | SKCM | 1 |
| p.A69T | UCEC | 1 |
| p.G1277E | BLCA | 1 |
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| TissGeneCNV for NWD1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NWD1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for NWD1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for NWD1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NWD1 |
| TissGeneDrug for NWD1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NWD1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
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