TissGeneSummary for SLC9C2 |
Gene summary |
Basic gene information | Gene symbol | SLC9C2 |
Gene name | solute carrier family 9, member C2 (putative) | |
Synonyms | SLC9A11 | |
Cytomap | UCSC genome browser: 1q25.1 | |
Type of gene | protein-coding | |
RefGenes | NM_178527.3, | |
Description | NHE-11Na(+)/H(+) exchanger 11sodium/hydrogen exchanger 11solute carrier family 9solute carrier family 9 member C2solute carrier family 9, member 11 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162753 | ||
HPRD : 15398 | ||
Vega : OTTHUMG00000034800 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC9C2 | |
BioGPS: 284525 | ||
Pathway | NCI Pathway Interaction Database: SLC9C2 | |
KEGG: SLC9C2 | ||
REACTOME: SLC9C2 | ||
Pathway Commons: SLC9C2 | ||
Context | iHOP: SLC9C2 | |
ligand binding site mutation search in PubMed: SLC9C2 | ||
UCL Cancer Institute: SLC9C2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC9C2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC9C2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SLC9C2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC9C2 |
TissGeneSNV for SLC9C2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R203W | SKCM | 5 |
p.R796C | SKCM | 4 |
p.R398Q | SKCM | 4 |
p.S307L | SKCM | 3 |
p.G200E | SKCM | 3 |
p.E957K | SKCM | 3 |
p.G529E | SKCM | 2 |
p.E466K | SKCM | 2 |
p.G382E | SKCM | 2 |
p.R166C | SKCM | 2 |
p.S94F | SKCM | 2 |
p.P623S | SKCM | 2 |
p.S91L | SKCM | 2 |
p.S170L | SKCM | 2 |
p.M496I | SKCM | 2 |
p.P390S | LUSC | 1 |
p.R526H | KICH | 1 |
p.T502S | LUAD | 1 |
p.I305M | PAAD | 1 |
p.P591S | SKCM | 1 |
p.I549M | BLCA | 1 |
p.A756S | ACC | 1 |
p.V282A | COAD | 1 |
p.W377* | LGG | 1 |
p.E775K | SKCM | 1 |
p.K693Q | COAD | 1 |
p.G186E | SKCM | 1 |
p.Q550X | STAD | 1 |
p.D685Y | READ | 1 |
p.G922E | SKCM | 1 |
p.D107N | SKCM | 1 |
p.T459K | SKCM | 1 |
p.M519_splice | LUSC | 1 |
p.L1010P | STAD | 1 |
p.A764D | SARC | 1 |
p.R738H | ESCA | 1 |
p.V392I | DLBC | 1 |
p.I135F | PRAD | 1 |
p.D797N | SKCM | 1 |
p.L84F | SKCM | 1 |
p.P83S | SKCM | 1 |
p.P98L | SKCM | 1 |
p.G379E | SKCM | 1 |
p.I225V | COAD | 1 |
p.F270L | SKCM | 1 |
p.R213T | HNSC | 1 |
p.P403L | SKCM | 1 |
p.I380V | SKCM | 1 |
p.L844X | COAD | 1 |
p.V345M | SKCM | 1 |
p.V1054G | LUAD | 1 |
p.S567N | LUAD | 1 |
p.C688R | ESCA | 1 |
p.Y423* | BLCA | 1 |
p.A236V | STAD | 1 |
p.L816I | HNSC | 1 |
p.D1056N | SKCM | 1 |
p.L351I | STAD | 1 |
p.A105S | ESCA | 1 |
p.T705K | LUAD | 1 |
p.I854V | LUSC | 1 |
p.G897A | HNSC | 1 |
p.T961I | SKCM | 1 |
p.I305L | READ | 1 |
p.G898S | SKCM | 1 |
p.L816P | STAD | 1 |
p.R398Q | KIRC | 1 |
p.S414L | SKCM | 1 |
p.S357N | STAD | 1 |
p.A195T | THYM | 1 |
p.M624I | SKCM | 1 |
p.R738C | STAD | 1 |
p.G136E | ESCA | 1 |
p.G64E | SKCM | 1 |
p.W147R | LIHC | 1 |
p.I681T | READ | 1 |
p.P336T | LUAD | 1 |
p.I517T | STAD | 1 |
p.C895W | SKCM | 1 |
p.E584K | SKCM | 1 |
p.F265L | STAD | 1 |
p.S918F | SKCM | 1 |
p.P14L | SKCM | 1 |
p.T1094N | LUAD | 1 |
p.V383I | SARC | 1 |
p.I184F | GBM | 1 |
p.R166H | ESCA | 1 |
p.I468M | CESC | 1 |
p.E484K | SKCM | 1 |
p.E832K | SKCM | 1 |
p.L85V | LUAD | 1 |
p.I726L | SKCM | 1 |
p.S88X | COAD | 1 |
p.L60F | SKCM | 1 |
p.F5L | BLCA | 1 |
p.R166L | LUAD | 1 |
p.D479A | HNSC | 1 |
p.L354F | LUAD | 1 |
p.T475A | SKCM | 1 |
p.R956C | ESCA | 1 |
p.R304I | STAD | 1 |
p.W147* | SKCM | 1 |
p.F878V | COAD | 1 |
p.E466D | STAD | 1 |
p.E959* | LUAD | 1 |
p.L841P | LUAD | 1 |
p.L16V | STAD | 1 |
p.I134K | SARC | 1 |
p.L350S | SKCM | 1 |
p.G275C | LUSC | 1 |
p.C582G | GBM | 1 |
p.K524T | READ | 1 |
p.V962I | SARC | 1 |
p.L790I | LUAD | 1 |
p.I305F | PRAD | 1 |
p.W371S | GBM | 1 |
p.E296K | STAD | 1 |
p.C18* | LIHC | 1 |
p.R304K | SKCM | 1 |
p.C823F | LUAD | 1 |
p.L531I | CESC | 1 |
p.M624I | LUAD | 1 |
p.F578L | KIRP | 1 |
p.R526H | PRAD | 1 |
p.C52* | LUAD | 1 |
p.A396T | HNSC | 1 |
p.V108G | LUAD | 1 |
p.D829N | SKCM | 1 |
p.I162T | PRAD | 1 |
p.E109X | READ | 1 |
p.Q450* | CESC | 1 |
p.I380N | SKCM | 1 |
p.V246I | LGG | 1 |
p.R370Q | SKCM | 1 |
p.G613X | READ | 1 |
p.S414* | LUAD | 1 |
p.D945N | SKCM | 1 |
p.L99F | SKCM | 1 |
p.H602D | BLCA | 1 |
p.T1001S | LUAD | 1 |
p.P293T | LUAD | 1 |
p.V1109I | SKCM | 1 |
p.M405I | LIHC | 1 |
p.L635X | READ | 1 |
p.C18Y | LIHC | 1 |
p.G529R | SKCM | 1 |
p.E220K | SKCM | 1 |
p.C545* | CESC | 1 |
p.G227* | SKCM | 1 |
p.D935Y | PAAD | 1 |
p.R526P | STAD | 1 |
p.R537Q | STAD | 1 |
p.S146L | SKCM | 1 |
p.R370Q | LGG | 1 |
p.G204S | SKCM | 1 |
p.A505G | COAD | 1 |
p.E484K | BLCA | 1 |
p.R166H | STAD | 1 |
p.V637I | KIRP | 1 |
p.L25F | SKCM | 1 |
p.N849T | SKCM | 1 |
p.I1011S | LIHC | 1 |
p.L34H | LUAD | 1 |
p.P590Q | ESCA | 1 |
p.L350W | SKCM | 1 |
p.R537L | UCS | 1 |
p.R738C | BLCA | 1 |
p.G68E | SKCM | 1 |
p.E366D | HNSC | 1 |
p.S422L | SKCM | 1 |
p.P851Q | SKCM | 1 |
p.M936I | BLCA | 1 |
p.C18X | LIHC | 1 |
p.S167F | SKCM | 1 |
p.V282A | KIRP | 1 |
p.R398Q | PAAD | 1 |
p.E924D | LUSC | 1 |
p.I197T | LGG | 1 |
p.L618W | LUSC | 1 |
p.R206K | SKCM | 1 |
p.I517M | STAD | 1 |
p.H312Q | COAD | 1 |
p.E187K | SKCM | 1 |
p.E76K | LUAD | 1 |
p.P358S | SKCM | 1 |
p.S357R | THYM | 1 |
p.A1090T | LUAD | 1 |
p.A448P | BLCA | 1 |
p.A105T | COAD | 1 |
p.D1036G | READ | 1 |
p.E990K | SKCM | 1 |
p.Y622H | HNSC | 1 |
p.I993M | HNSC | 1 |
p.T58M | THYM | 1 |
p.I1048S | LIHC | 1 |
p.L1010I | LUAD | 1 |
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TissGeneCNV for SLC9C2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC9C2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC9C2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC9C2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC9C2 |
TissGeneDrug for SLC9C2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC9C2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033860 | Psoriasis | 1 | BeFree |