TissGeneSummary for C2orf61 |
Gene summary |
Basic gene information | Gene symbol | C2orf61 |
Gene name | chromosome 2 open reading frame 61 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p21 | |
Type of gene | protein-coding | |
RefGenes | NM_001163561.1, NM_173649.2, | |
Description | uncharacterized protein C2orf61 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000239605 | ||
HPRD : 08273 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C2orf61 | |
BioGPS: 285051 | ||
Pathway | NCI Pathway Interaction Database: C2orf61 | |
KEGG: C2orf61 | ||
REACTOME: C2orf61 | ||
Pathway Commons: C2orf61 | ||
Context | iHOP: C2orf61 | |
ligand binding site mutation search in PubMed: C2orf61 | ||
UCL Cancer Institute: C2orf61 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C2orf61 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for C2orf61 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.024789863 | -0.340640906 | 1.365430769 | 7.51E-08 | 5.39E-07 |
ESCA | 1.439280773 | 0.152689863 | 1.286590909 | 0.00505 | 0.039764806 |
STAD | 1.234771113 | 0.231399238 | 1.003371875 | 3.73E-05 | 0.000338257 |
Top |
TissGene-miRNA for C2orf61 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for C2orf61 |
TissGeneSNV for C2orf61 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S12P | KIRC | 1 |
p.A7P | BLCA | 1 |
p.P125L | SKCM | 1 |
p.I13T | KIRP | 1 |
p.N244I | UCEC | 1 |
p.P85S | UCEC | 1 |
p.K151I | BLCA | 1 |
p.P83L | UCEC | 1 |
p.T123A | UCEC | 1 |
p.D119H | HNSC | 1 |
p.P227A | ESCA | 1 |
p.P50S | SKCM | 1 |
p.P83L | SKCM | 1 |
p.P179Q | ESCA | 1 |
p.I124F | UCEC | 1 |
p.T8I | HNSC | 1 |
p.N74T | PRAD | 1 |
p.F104L | THYM | 1 |
p.P4T | BLCA | 1 |
p.I24V | LGG | 1 |
p.P125A | LUSC | 1 |
p.C157Y | DLBC | 1 |
p.N77S | LUAD | 1 |
Top |
TissGeneCNV for C2orf61 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for C2orf61 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP249981 | C2orf61-SECISBP2L | chr2:47388915 | chr15:49288610 | |
Chimerdb3.0 | ChiTaRs | NA | AI039637 | C2orf61-MCF2L2 | chr2:47387852 | chr3:182988389 | |
Chimerdb3.0 | ChiTaRs | NA | DA514557 | C2orf61-GDI2 | chr2:47403650 | chr10:5838773 | |
Chimerdb3.0 | ChiTaRs | NA | BM827779 | C2orf61-UCP2 | chr2:47403650 | chr11:73693832 | |
Chimerdb3.0 | ChiTaRs | NA | BP374554 | C2orf61-LOC642776 | chr2:47403650 | chrX:115052439 | |
Chimerdb3.0 | ChiTaRs | NA | AI688098 | C2orf61-HIST1H2BC | chr2:47387504 | chr6:26123755 | |
Chimerdb3.0 | ChiTaRs | NA | BP219658 | C2orf61-CABIN1 | chr2:47403650 | chr22:24491284 | |
Chimerdb3.0 | ChiTaRs | NA | BF927057 | SAFB-C2orf61 | chr19:5653360 | chr2:47388952 | |
Chimerdb3.0 | ChiTaRs | NA | BF700255 | ESD-C2orf61 | chr13:47371264 | chr2:47387721 | |
Chimerdb3.0 | ChiTaRs | NA | BF930423 | SAFB-C2orf61 | chr19:5653360 | chr2:47388906 | |
TCGAfusionPortal | PRADA | OV | TCGA-23-1027-01A | C2orf61-ALK | Out-of-frame | Chr2:47357080 | Chr2:29754982 |
Top |
TissGeneNet for C2orf61 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for C2orf61 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for C2orf61 |
TissGeneDrug for C2orf61 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for C2orf61 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |