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| TissGeneSummary for CYP4V2 |
 Gene summary |
| Basic gene information | Gene symbol | CYP4V2 |
| Gene name | cytochrome P450, family 4, subfamily V, polypeptide 2 | |
| Synonyms | BCD|CYP4AH1 | |
| Cytomap | UCSC genome browser: 4q35.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_207352.3, | |
| Description | cytochrome P450 4V2docosahexaenoic acid omega-hydroxylase CYP4V2 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 608614 | |
| HGNC : HGNC | ||
| HPRD : 16777 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CYP4V2 | |
| BioGPS: 285440 | ||
| Pathway | NCI Pathway Interaction Database: CYP4V2 | |
| KEGG: CYP4V2 | ||
| REACTOME: CYP4V2 | ||
| Pathway Commons: CYP4V2 | ||
| Context | iHOP: CYP4V2 | |
| ligand binding site mutation search in PubMed: CYP4V2 | ||
| UCL Cancer Institute: CYP4V2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of CYP4V2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0010430 | fatty acid omega-oxidation | 19661213 | GO:0010430 | fatty acid omega-oxidation | 19661213 |
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| TissGeneExp for CYP4V2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -2.328005161 | -0.506903201 | -1.821101961 | 6.72E-20 | 7.80E-19 |
| LIHC | 0.921655348 | 2.359531348 | -1.437876 | 4.16E-11 | 5.70E-10 |
| KICH | -0.507062652 | 0.546501348 | -1.053564 | 1.87E-05 | 5.61E-05 |
| BLCA | -2.107556967 | -1.043314862 | -1.064242105 | 0.00834 | 0.038885031 |
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| TissGene-miRNA for CYP4V2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CYP4V2 |
| TissGeneSNV for CYP4V2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L22V | COAD | 2 |
| p.R221H | THYM | 1 |
| p.R221C | SKCM | 1 |
| p.E407K | BLCA | 1 |
| p.P459S | SKCM | 1 |
| p.E202_splice | LUSC | 1 |
| p.A278T | COAD | 1 |
| p.S347Y | BLCA | 1 |
| p.S394F | SKCM | 1 |
| p.P393L | SKCM | 1 |
| p.R233I | UCS | 1 |
| p.M236I | LUSC | 1 |
| p.E310K | UCEC | 1 |
| p.G463V | LUAD | 1 |
| p.R368H | LUSC | 1 |
| p.L194R | STAD | 1 |
| p.S482L | LUAD | 1 |
| p.E491* | UCEC | 1 |
| p.R443W | BRCA | 1 |
| p.R390H | PRAD | 1 |
| p.E160K | SKCM | 1 |
| p.M149I | LGG | 1 |
| p.D285N | SKCM | 1 |
| p.R232X | READ | 1 |
| p.R508C | SKCM | 1 |
| p.T81R | LUAD | 1 |
| p.K471T | UCEC | 1 |
| p.E271D | LUAD | 1 |
| p.R221H | READ | 1 |
| p.K249N | SKCM | 1 |
| p.R452H | PAAD | 1 |
| p.S145F | DLBC | 1 |
| p.G512D | LGG | 1 |
| p.R400C | LUAD | 1 |
| p.K125M | STAD | 1 |
| p.G469C | UCEC | 1 |
| p.E373Q | LUAD | 1 |
| p.R221L | LUAD | 1 |
| p.G95R | SKCM | 1 |
| p.P396S | SKCM | 1 |
| p.S482L | READ | 1 |
| p.E228G | STAD | 1 |
| p.R85H | UCEC | 1 |
| p.L22V | READ | 1 |
| p.D360G | LUAD | 1 |
| p.F445I | SKCM | 1 |
| p.E442K | LUAD | 1 |
| p.P349S | SKCM | 1 |
| p.S482L | BLCA | 1 |
| p.M327I | COAD | 1 |
| p.M149I | LUAD | 1 |
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| TissGeneCNV for CYP4V2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CYP4V2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CYP4V2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| COAD (tumor) | COAD (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| KICH (tumor) | KICH (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| STAD (tumor) | STAD (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| THCA (tumor) | THCA (normal) |
| CYP4V2, SIN3A, ZNF420 (tumor) | CYP4V2, SIN3A, ZNF420 (normal) |
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| TissGeneProg for CYP4V2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CYP4V2 |
| TissGeneDrug for CYP4V2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CYP4V2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1859486 | BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY | 19 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0149871 | Deep Vein Thrombosis | 2 | BeFree |
| umls:C0014121 | Bacterial Endocarditis | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042487 | Venous Thrombosis | 1 | GAD,LHGDN |
| umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
| umls:C0340708 | Deep vein thrombosis of lower limb | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1285498 | Vegetation | 1 | BeFree |
| umls:C1541923 | Infective endocarditis | 1 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
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