TissGeneSummary for CAGE1 |
Gene summary |
Basic gene information | Gene symbol | CAGE1 |
Gene name | cancer antigen 1 | |
Synonyms | CT3|CT95|CTAG3|bA69L16.7 | |
Cytomap | UCSC genome browser: 6p24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_175745.3, NM_001170692.1,NM_001170693.1,NM_205864.2, | |
Description | cancer-associated gene 1 proteincancer/testis antigen 3cancer/testis antigen 95cancer/testis antigen gene 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608304 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164304 | ||
HPRD : 10511 | ||
Vega : OTTHUMG00000014200 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAGE1 | |
BioGPS: 285782 | ||
Pathway | NCI Pathway Interaction Database: CAGE1 | |
KEGG: CAGE1 | ||
REACTOME: CAGE1 | ||
Pathway Commons: CAGE1 | ||
Context | iHOP: CAGE1 | |
ligand binding site mutation search in PubMed: CAGE1 | ||
UCL Cancer Institute: CAGE1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CAGE1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CAGE1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.420891616 | -1.927224949 | 1.506333333 | 1.43E-10 | 5.30E-10 |
HNSC | 0.234560094 | -1.32551665 | 1.560076744 | 7.23E-13 | 2.85E-11 |
BLCA | -0.749823505 | -1.998497189 | 1.248673684 | 0.00149 | 0.009921437 |
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TissGene-miRNA for CAGE1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CAGE1 |
TissGeneSNV for CAGE1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E476K | SKCM | 4 |
p.E403K | UCEC | 3 |
p.R806* | LUAD | 1 |
p.Q492* | SKCM | 1 |
p.T103A | LIHC | 1 |
p.F484L | UCS | 1 |
p.P233S | SKCM | 1 |
p.L193I | ESCA | 1 |
p.E422X | PCPG | 1 |
p.K796N | LIHC | 1 |
p.E115K | SKCM | 1 |
p.I395T | BRCA | 1 |
p.E99X | COAD | 1 |
p.N255S | SKCM | 1 |
p.E740* | UCEC | 1 |
p.S434F | LGG | 1 |
p.N544S | HNSC | 1 |
p.R366S | STAD | 1 |
p.E334K | SKCM | 1 |
p.Y721C | UCEC | 1 |
p.K26X | SKCM | 1 |
p.E539K | BLCA | 1 |
p.S543I | UCEC | 1 |
p.R608* | LUAD | 1 |
p.T169I | DLBC | 1 |
p.G715* | HNSC | 1 |
p.D21N | KIRC | 1 |
p.K396Q | READ | 1 |
p.K357T | STAD | 1 |
p.E437Q | BLCA | 1 |
p.E307K | BLCA | 1 |
p.V259A | LIHC | 1 |
p.S615Y | LUAD | 1 |
p.E495K | LUAD | 1 |
p.K608I | LUAD | 1 |
p.E340K | SKCM | 1 |
p.I229L | UCEC | 1 |
p.F214L | UCEC | 1 |
p.M200L | KIRC | 1 |
p.Q534* | CESC | 1 |
p.T131I | STAD | 1 |
p.K162* | SKCM | 1 |
p.E242K | SKCM | 1 |
p.Q41K | LAML | 1 |
p.L376W | COAD | 1 |
p.E227* | UCEC | 1 |
p.H588Y | HNSC | 1 |
p.V299L | OV | 1 |
p.A135T | COAD | 1 |
p.T267I | STAD | 1 |
p.T586M | GBM | 1 |
p.E198K | SKCM | 1 |
p.E422* | PCPG | 1 |
p.A467T | SKCM | 1 |
p.N2D | UCEC | 1 |
p.D754G | UCEC | 1 |
p.L494R | LUSC | 1 |
p.S636Y | UCEC | 1 |
p.K493T | STAD | 1 |
p.K307T | UCEC | 1 |
p.Q456* | OV | 1 |
p.E635K | SKCM | 1 |
p.E573Q | BLCA | 1 |
p.S588Y | LUAD | 1 |
p.L193V | BLCA | 1 |
p.E251K | SKCM | 1 |
p.A782P | LUSC | 1 |
p.E339K | SKCM | 1 |
p.E451K | THYM | 1 |
p.H49Q | COAD | 1 |
p.S486F | SKCM | 1 |
p.H452Y | HNSC | 1 |
p.K705N | LUSC | 1 |
p.Y558C | UCEC | 1 |
p.A217D | LUAD | 1 |
p.I576S | UCEC | 1 |
p.E490K | CESC | 1 |
p.R553K | SKCM | 1 |
p.K307N | COAD | 1 |
p.D535E | STAD | 1 |
p.E543K | SKCM | 1 |
p.L628H | LUAD | 1 |
p.K673R | LIHC | 1 |
p.E315* | UCEC | 1 |
p.D546Y | UCEC | 1 |
p.E203K | SKCM | 1 |
p.L485F | KIRC | 1 |
p.H722R | BLCA | 1 |
p.R835I | BLCA | 1 |
p.P287L | LUAD | 1 |
p.P15S | READ | 1 |
p.P630S | UCEC | 1 |
p.S298F | UCEC | 1 |
p.D729N | SKCM | 1 |
p.R423K | PRAD | 1 |
p.D719V | SKCM | 1 |
p.E181K | SKCM | 1 |
p.R339W | STAD | 1 |
p.A331T | SKCM | 1 |
p.A782T | ESCA | 1 |
p.S786Y | LUAD | 1 |
p.E83K | CESC | 1 |
p.E833K | SKCM | 1 |
p.P220S | SKCM | 1 |
p.E158A | UCEC | 1 |
p.N391S | SKCM | 1 |
p.Q397* | BLCA | 1 |
p.Q356X | SKCM | 1 |
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TissGeneCNV for CAGE1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CAGE1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A2-A0CX-01A | SSR1-CAGE1 | Out-of-Frame | chr6:7301542 | chr6:7330120 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0CX-01A | SSR1-CAGE1 | Out-of-frame | Chr6:7301543 | Chr6:7330121 |
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TissGeneNet for CAGE1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CAGE1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CAGE1 |
TissGeneDrug for CAGE1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CAGE1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree,LHGDN |