TissGeneSummary for FAM133A |
Gene summary |
Basic gene information | Gene symbol | FAM133A |
Gene name | family with sequence similarity 133, member A | |
Synonyms | CT115 | |
Cytomap | UCSC genome browser: Xq21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001171109.1, NM_001171110.1,NM_001171111.1,NM_173698.2, | |
Description | cancer/testis antigen 115protein FAM133A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000179083 | ||
HPRD : 06562 | ||
Vega : OTTHUMG00000021975 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM133A | |
BioGPS: 286499 | ||
Pathway | NCI Pathway Interaction Database: FAM133A | |
KEGG: FAM133A | ||
REACTOME: FAM133A | ||
Pathway Commons: FAM133A | ||
Context | iHOP: FAM133A | |
ligand binding site mutation search in PubMed: FAM133A | ||
UCL Cancer Institute: FAM133A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM133A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM133A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.735136748 | -0.69619607 | -1.038940678 | 1.55E-06 | 5.74E-06 |
KICH | -3.659630578 | -1.919774578 | -1.739856 | 7.79E-10 | 5.01E-09 |
LUSC | -1.474440304 | -2.625110892 | 1.150670588 | 0.00345 | 0.005939908 |
LIHC | -0.627300578 | -2.572128578 | 1.944828 | 0.00045 | 0.001323775 |
LUAD | -0.787178302 | -2.583886923 | 1.796708621 | 5.87E-05 | 0.000152743 |
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TissGene-miRNA for FAM133A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM133A |
TissGeneSNV for FAM133A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T40I | HNSC | 1 |
p.G128V | THCA | 1 |
p.G2W | STAD | 1 |
p.N50K | READ | 1 |
p.K134N | LUAD | 1 |
p.Q31H | STAD | 1 |
p.S163X | PAAD | 1 |
p.E220K | SKCM | 1 |
p.A59T | HNSC | 1 |
p.S107F | COAD | 1 |
p.W41L | LUAD | 1 |
p.R137C | UCEC | 1 |
p.A17D | LUAD | 1 |
p.K154N | ESCA | 1 |
p.S195L | SKCM | 1 |
p.G54D | CESC | 1 |
p.T146M | UCEC | 1 |
p.E49Q | LUAD | 1 |
p.E197K | LUAD | 1 |
p.R7Q | STAD | 1 |
p.E60V | LUSC | 1 |
p.K45N | COAD | 1 |
p.I14L | COAD | 1 |
p.E124K | BLCA | 1 |
p.E201K | CESC | 1 |
p.E213K | SKCM | 1 |
p.D165N | SKCM | 1 |
p.A57T | STAD | 1 |
p.R130K | SKCM | 1 |
p.S107F | SKCM | 1 |
p.L73H | BLCA | 1 |
p.X249Y | STAD | 1 |
p.K134* | UCEC | 1 |
p.E67K | BRCA | 1 |
p.I30F | SKCM | 1 |
p.K96Q | SKCM | 1 |
p.K134R | LIHC | 1 |
p.L80V | UCEC | 1 |
p.K221I | STAD | 1 |
p.E67K | COAD | 1 |
p.G21C | LUAD | 1 |
p.R93K | SKCM | 1 |
p.R38K | ESCA | 1 |
p.S163* | PAAD | 1 |
p.S142F | READ | 1 |
p.D203Y | LUAD | 1 |
p.K45N | UCEC | 1 |
p.S115R | HNSC | 1 |
p.G54V | COAD | 1 |
p.S192F | SKCM | 1 |
p.K45N | CESC | 1 |
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TissGeneCNV for FAM133A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM133A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM133A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM133A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM133A |
TissGeneDrug for FAM133A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM133A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |