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| TissGeneSummary for GRK4 |
 Gene summary |
| Basic gene information | Gene symbol | GRK4 |
| Gene name | G protein-coupled receptor kinase 4 | |
| Synonyms | GPRK2L|GPRK4|GRK4a|IT11 | |
| Cytomap | UCSC genome browser: 4p16.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001004056.1, NM_001004057.1,NM_005307.2,NM_182982.2, | |
| Description | ITI1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 137026 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125388 | ||
| HPRD : 00656 | ||
| Vega : OTTHUMG00000159914 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRK4 | |
| BioGPS: 2868 | ||
| Pathway | NCI Pathway Interaction Database: GRK4 | |
| KEGG: GRK4 | ||
| REACTOME: GRK4 | ||
| Pathway Commons: GRK4 | ||
| Context | iHOP: GRK4 | |
| ligand binding site mutation search in PubMed: GRK4 | ||
| UCL Cancer Institute: GRK4 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of GRK4 | ||
| Description by TissGene annotations | TissgsLTS Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0031623 | receptor internalization | 20074556 | GO:0031623 | receptor internalization | 20074556 |
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| TissGeneExp for GRK4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| ESCA | 0.104809216 | 1.208409216 | -1.1036 | 5.61E-05 | 0.002151145 |
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| TissGene-miRNA for GRK4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GRK4 |
| TissGeneSNV for GRK4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R108K | SKCM | 2 |
| p.R344* | UCEC | 2 |
| p.R65L | COAD | 1 |
| p.R68S | LUAD | 1 |
| p.P75L | SKCM | 1 |
| p.E161* | UCEC | 1 |
| p.R344* | LUAD | 1 |
| p.G197A | LUAD | 1 |
| p.D124Y | UCEC | 1 |
| p.R307I | COAD | 1 |
| p.K184N | COAD | 1 |
| p.R307I | UCEC | 1 |
| p.G561R | SKCM | 1 |
| p.V448M | LGG | 1 |
| p.E515K | BLCA | 1 |
| p.D524V | UCEC | 1 |
| p.L262V | SKCM | 1 |
| p.A440E | CHOL | 1 |
| p.I481M | BRCA | 1 |
| p.G210E | SKCM | 1 |
| p.S244N | KIRC | 1 |
| p.R327W | LGG | 1 |
| p.S55T | ACC | 1 |
| p.A203T | LGG | 1 |
| p.G63E | CESC | 1 |
| p.R323C | SKCM | 1 |
| p.F554L | CESC | 1 |
| p.L56F | SKCM | 1 |
| p.Y292F | LUSC | 1 |
| p.R327Q | PRAD | 1 |
| p.V192A | UCS | 1 |
| p.D405N | SKCM | 1 |
| p.D95N | ESCA | 1 |
| p.N453T | LGG | 1 |
| p.L375M | PAAD | 1 |
| p.D399N | SKCM | 1 |
| p.D330A | SKCM | 1 |
| p.E316D | COAD | 1 |
| p.S48F | SKCM | 1 |
| p.G280V | COAD | 1 |
| p.V247I | BRCA | 1 |
| p.T544I | LUAD | 1 |
| p.S19W | CESC | 1 |
| p.V247I | COAD | 1 |
| p.R26C | BRCA | 1 |
| p.K314R | SKCM | 1 |
| p.G37R | MESO | 1 |
| p.A472V | KIRP | 1 |
| p.F109L | UCEC | 1 |
| p.F386L | LUAD | 1 |
| p.R237I | LGG | 1 |
| p.R222G | STAD | 1 |
| p.R98Q | UCEC | 1 |
| p.N317T | COAD | 1 |
| p.K392I | HNSC | 1 |
| p.V309I | UCEC | 1 |
| p.R26C | UCEC | 1 |
| p.V486A | COAD | 1 |
| p.E4Q | BLCA | 1 |
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| TissGeneCNV for GRK4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GRK4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF329649 | GRK4-GRK4 | chr4:3023248 | chr4:3023249 | |
| Chimerdb3.0 | ChiTaRs | NA | BF355916 | TET3-GRK4 | chr2:74308381 | chr4:3039863 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49L-01A | ADD1-GRK4 | Out-of-Frame | chr4:2916767 | chr4:3021367 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NW-01A | SRD5A1-GRK4 | 3'UTR-CDS | chr5:6663079 | chr4:3024140 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-DI-A2QY-01A | HTT-GRK4 | Out-of-Frame | chr4:3076815 | chr4:3042298 |
| TCGAfusionPortal | PRADA | BLCA | TCGA-CU-A3QU-01A | HTT-GRK4 | In-frame | Chr4:3132150 | Chr4:3015415 |
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| TissGeneNet for GRK4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| COAD (tumor) | COAD (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| KICH (tumor) | KICH (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| STAD (tumor) | STAD (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| THCA (tumor) | THCA (normal) |
| GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (tumor) | GRK4, IKBKG, NEDD4, CALM1, FSHR, BDKRB2 (normal) |
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| TissGeneProg for GRK4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRK4 |
| TissGeneDrug for GRK4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GRK4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020538 | Hypertensive disease | 22 | BeFree,GAD,LHGDN |
| umls:C0085580 | Essential Hypertension | 10 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | GAD |
| umls:C0264657 | Renal sclerosis with hypertension | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0020544 | Renal hypertension | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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