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| TissGeneSummary for KRT6C |
 Gene summary |
| Basic gene information | Gene symbol | KRT6C |
| Gene name | keratin 6C | |
| Synonyms | K6E|KRT6E|PPKNEFD | |
| Cytomap | UCSC genome browser: 12q13.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173086.4, | |
| Description | CK-6CCK-6EK6Ccytokeratin-6Ccytokeratin-6Ekeratin 6Ekeratin K6hkeratin, type II cytoskeletal 6Ckeratin-6Ctype-II keratin Kb12 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612315 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170465 | ||
| HPRD : 17247 | ||
| Vega : OTTHUMG00000169596 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KRT6C | |
| BioGPS: 286887 | ||
| Pathway | NCI Pathway Interaction Database: KRT6C | |
| KEGG: KRT6C | ||
| REACTOME: KRT6C | ||
| Pathway Commons: KRT6C | ||
| Context | iHOP: KRT6C | |
| ligand binding site mutation search in PubMed: KRT6C | ||
| UCL Cancer Institute: KRT6C | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCASKCM | |
| Reference showing the relevant tissue of KRT6C | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KRT6C |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -2.3855521 | -1.213990562 | -1.171561538 | 1.09E-05 | 5.97E-05 |
| BRCA | -1.310333139 | 0.119516861 | -1.42985 | 1.35E-05 | 3.31E-05 |
| LUAD | -0.352147325 | -3.15200767 | 2.799860345 | 4.66E-09 | 2.18E-08 |
| COAD | -1.761463638 | -3.823029023 | 2.061565385 | 4.05E-06 | 2.02E-05 |
| LUSC | 6.969111701 | -1.046074574 | 8.015186275 | 5.36E-25 | 1.18E-23 |
| THCA | -2.888153404 | -4.017765268 | 1.129611864 | 7.10E-05 | 0.000197977 |
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| TissGene-miRNA for KRT6C |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KRT6C |
| TissGeneSNV for KRT6C |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M387I | SKCM | 3 |
| p.V481I | COAD | 2 |
| p.Y341* | HNSC | 1 |
| p.T358I | SKCM | 1 |
| p.R15H | SARC | 1 |
| p.S561N | SKCM | 1 |
| p.D255N | SKCM | 1 |
| p.K378M | PRAD | 1 |
| p.G536E | SKCM | 1 |
| p.G480R | HNSC | 1 |
| p.D329E | BLCA | 1 |
| p.L191M | UCEC | 1 |
| p.R232Q | UCS | 1 |
| p.E264D | STAD | 1 |
| p.D440G | UCEC | 1 |
| p.S13N | BRCA | 1 |
| p.S37F | SKCM | 1 |
| p.E294K | BLCA | 1 |
| p.A410D | UCEC | 1 |
| p.G536E | BLCA | 1 |
| p.E431K | SKCM | 1 |
| p.D372H | KIRC | 1 |
| p.G53R | PCPG | 1 |
| p.R160W | COAD | 1 |
| p.M452T | PCPG | 1 |
| p.V398A | STAD | 1 |
| p.R232Q | THYM | 1 |
| p.G53* | UCEC | 1 |
| p.R158W | STAD | 1 |
| p.R260H | SKCM | 1 |
| p.T4A | UCEC | 1 |
| p.E342K | UCEC | 1 |
| p.D179N | COAD | 1 |
| p.S505C | LIHC | 1 |
| p.Y562H | STAD | 1 |
| p.R160Q | PAAD | 1 |
| p.S237L | ESCA | 1 |
| p.E283K | LUAD | 1 |
| p.E479K | SKCM | 1 |
| p.M279I | SKCM | 1 |
| p.G471S | SKCM | 1 |
| p.V38M | STAD | 1 |
| p.I333N | STAD | 1 |
| p.S5F | SKCM | 1 |
| p.S557F | SKCM | 1 |
| p.S530C | LIHC | 1 |
| p.G416R | SKCM | 1 |
| p.M309T | LGG | 1 |
| p.L330M | PRAD | 1 |
| p.R30P | ESCA | 1 |
| p.K287T | UCEC | 1 |
| p.G499S | LGG | 1 |
| p.D459H | BLCA | 1 |
| p.Q308K | SKCM | 1 |
| p.Y517C | UCEC | 1 |
| p.D289Y | UCS | 1 |
| p.E431K | PRAD | 1 |
| p.N324S | STAD | 1 |
| p.D303G | STAD | 1 |
| p.R260C | READ | 1 |
| p.R415H | PRAD | 1 |
| p.K421N | LUSC | 1 |
| p.G478D | THYM | 1 |
| p.R369T | HNSC | 1 |
| p.E417D | LUAD | 1 |
| p.G233S | KIRC | 1 |
| p.G43D | SARC | 1 |
| p.E417* | LUAD | 1 |
| p.329_330DL>EM | BLCA | 1 |
| p.G512E | SKCM | 1 |
| p.S12N | LGG | 1 |
| p.L330M | BLCA | 1 |
| p.P147S | LGG | 1 |
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| TissGeneCNV for KRT6C |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KRT6C |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-Q9-A6FW-01A7 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862330 | chr12:52881164 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-Q9-A6FW-01A7 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862514 | chr12:52881017 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-Q9-A6FW-01A7 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862586 | chr12:52881205 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-Q9-A6FW-01A7 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862621 | chr12:52881012 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-IC-A6RE-11A5 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862330 | chr12:52881164 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-IC-A6RE-11A5 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862514 | chr12:52881017 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-IC-A6RE-11A5 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862586 | chr12:52881205 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-IC-A6RE-11A5 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862621 | chr12:52881012 |
| Chimerdb3.0 | TopHat-Fusion | STAD | TCGA-LN-A5U7-01A1 | KRT6C-KRT6A | 3'UTR-3'UTR | chr12:52862808 | chr12:52881429 |
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| TissGeneNet for KRT6C |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| COAD (tumor) | COAD (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| KICH (tumor) | KICH (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| STAD (tumor) | STAD (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| THCA (tumor) | THCA (normal) |
| KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (tumor) | KRT6C, TP63, CUL2, CUL1, COPS5, PITX3 (normal) |
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| TissGeneProg for KRT6C |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KRT6C |
| TissGeneDrug for KRT6C |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KRT6C |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2931923 | Hyperkeratosis of the palms and soles and esophageal papillomas | 4 | BeFree |
| umls:C0265334 | Pachyonychia Congenita | 1 | BeFree |
| umls:C3810394 | PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC, FOCAL OR DIFFUSE | 1 | CLINVAR,ORPHANET,UNIPROT |
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