TissGeneSummary for GPX3 |
Gene summary |
Basic gene information | Gene symbol | GPX3 |
Gene name | glutathione peroxidase 3 (plasma) | |
Synonyms | GPx-P|GSHPx-3|GSHPx-P | |
Cytomap | UCSC genome browser: 5q23 | |
Type of gene | protein-coding | |
RefGenes | NM_002084.3, | |
Description | GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3plasma glutathione peroxidase | |
Modification date | 20141222 | |
dbXrefs | MIM : 138321 | |
HGNC : HGNC | ||
Ensembl : ENSG00000211445 | ||
HPRD : 11750 | ||
Vega : OTTHUMG00000163693 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GPX3 | |
BioGPS: 2878 | ||
Pathway | NCI Pathway Interaction Database: GPX3 | |
KEGG: GPX3 | ||
REACTOME: GPX3 | ||
Pathway Commons: GPX3 | ||
Context | iHOP: GPX3 | |
ligand binding site mutation search in PubMed: GPX3 | ||
UCL Cancer Institute: GPX3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHUVM | |
Reference showing the relevant tissue of GPX3 | ||
Description by TissGene annotations | Protective TissGene in OS Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0051289 | protein homotetramerization | 3693360 | GO:0051289 | protein homotetramerization | 3693360 |
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TissGeneExp for GPX3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.137117588 | 1.636184738 | -2.773302326 | 1.32E-13 | 6.19E-12 |
COAD | -2.02566231 | 0.38748769 | -2.41315 | 5.63E-09 | 5.43E-08 |
KIRP | 3.261749709 | 5.646868459 | -2.38511875 | 1.33E-05 | 5.40E-05 |
BRCA | -1.28200698 | 2.10779302 | -3.3898 | 2.33E-37 | 5.20E-36 |
PRAD | -0.814181541 | 0.489808843 | -1.303990385 | 1.60E-11 | 4.91E-10 |
STAD | -0.871062791 | 1.553940334 | -2.425003125 | 3.29E-11 | 4.62E-09 |
LUSC | -0.490133502 | 3.28087238 | -3.771005882 | 4.10E-31 | 2.15E-29 |
LUAD | 0.65820639 | 3.071890873 | -2.413684483 | 6.26E-23 | 1.90E-21 |
BLCA | -1.682010489 | 1.022957933 | -2.704968421 | 2.33E-08 | 1.84E-06 |
KICH | 2.545344459 | 4.286460459 | -1.741116 | 0.000674 | 0.001500501 |
ESCA | -2.075776996 | 1.12447755 | -3.200254545 | 7.81E-06 | 0.000913862 |
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TissGene-miRNA for GPX3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GPX3 |
TissGeneSNV for GPX3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R123G | LUAD | 1 |
p.G44E | SKCM | 1 |
p.R180S | KIRC | 1 |
p.G93S | BLCA | 1 |
p.M174I | SKCM | 1 |
p.F151V | UCEC | 1 |
p.S28L | STAD | 1 |
p.R123* | BLCA | 1 |
p.G110E | SKCM | 1 |
p.K147I | KIRC | 1 |
p.D139N | SKCM | 1 |
p.E136Q | BLCA | 1 |
p.S20L | LUAD | 1 |
p.V69M | LUAD | 1 |
p.V223I | SKCM | 1 |
p.I193M | STAD | 1 |
p.E42K | SKCM | 1 |
p.A220V | UCEC | 1 |
p.L162F | BLCA | 1 |
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TissGeneCNV for GPX3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GPX3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CV421185 | GPX3-NSMCE1 | chr5:150408290 | chr16:27238452 | |
Chimerdb3.0 | ChiTaRs | NA | AA740310 | GPX3-RPN2 | chr5:150408522 | chr20:35812585 | |
Chimerdb3.0 | ChiTaRs | NA | BG430541 | GPX3-GPX3 | chr5:150407832 | chr5:150406467 | |
Chimerdb3.0 | ChiTaRs | NA | BG896291 | GPX3-GPX3 | chr5:150408090 | chr5:150408072 | |
Chimerdb3.0 | ChiTaRs | NA | BG927502 | GPX3-GPX3 | chr5:150407992 | chr5:150407030 | |
Chimerdb3.0 | ChiTaRs | NA | BF878552 | GPX3-GPX3 | chr5:150407052 | chr5:150404898 | |
Chimerdb3.0 | ChiTaRs | NA | AW794509 | GPX3-S100A8 | chr5:150407982 | chr1:153362669 | |
Chimerdb3.0 | ChiTaRs | NA | CB044109 | INPP4B-GPX3 | chr4:142963356 | chr5:150406475 | |
Chimerdb3.0 | ChiTaRs | NA | BG990596 | AFAP1L2-GPX3 | chr10:116057013 | chr5:150406494 | |
Chimerdb3.0 | ChiTaRs | NA | W25873 | GPX3-GPX3 | chr5:150407578 | chr5:150407726 | |
Chimerdb3.0 | ChiTaRs | NA | BF848871 | AARS-GPX3 | chr16:70287931 | chr5:150407985 | |
TCGAfusionPortal | PRADA | THCA | TCGA-BJ-A2N8-01A | GPX3-SEC63 | NA | Chr5:150408548 | Chr6:108214782 |
TCGAfusionPortal | PRADA | THCA | TCGA-DJ-A4UR-01A | GPX3-SQSTM1 | 3UTR-CDS | Chr5:150408548 | Chr5:179250858 |
TCGAfusionPortal | PRADA | THCA | TCGA-DJ-A4V2-01A | GPX3-CHD4 | NA | Chr5:150408515 | Chr12:6710696 |
TCGAfusionPortal | PRADA | THCA | TCGA-EM-A22L-01A | GPX3-SEC63 | NA | Chr5:150408548 | Chr6:108214782 |
TCGAfusionPortal | PRADA | THCA | TCGA-FY-A3W9-01A | GPX3-CHD4 | NA | Chr5:150408515 | Chr12:6710696 |
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TissGeneNet for GPX3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GPX3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GPX3 |
TissGeneDrug for GPX3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00143 | Glutathione | Cofactor | Small molecule | Approved|Nutraceutical |
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TissGeneDisease for GPX3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
umls:C0596263 | Carcinogenesis | 6 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
umls:C0600139 | Prostate carcinoma | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 5 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 5 | BeFree |
umls:C0001418 | Adenocarcinoma | 4 | BeFree,CTD_human,LHGDN |
umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
umls:C0028754 | Obesity | 4 | BeFree,CTD_human,RGD |
umls:C0038454 | Cerebrovascular accident | 4 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0948008 | Ischemic stroke | 3 | BeFree,GAD |
umls:C2239176 | Liver carcinoma | 3 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree,GAD |
umls:C0014175 | Endometriosis | 2 | CTD_human |
umls:C0023903 | Liver neoplasms | 2 | BeFree,CTD_human |
umls:C0024115 | Lung diseases | 2 | BeFree,RGD |
umls:C0024121 | Lung Neoplasms | 2 | CTD_human |
umls:C0040136 | Thyroid Neoplasm | 2 | GAD,LHGDN |
umls:C0085580 | Essential Hypertension | 2 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 2 | GAD |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0004763 | Barrett Esophagus | 1 | LHGDN |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | LHGDN |
umls:C0007787 | Transient Ischemic Attack | 1 | BeFree |
umls:C0008497 | Choriocarcinoma | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
umls:C0011849 | Diabetes Mellitus | 1 | LHGDN |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0013080 | Down Syndrome | 1 | BeFree |
umls:C0013264 | Muscular Dystrophy, Duchenne | 1 | BeFree |
umls:C0014170 | Endometrial Neoplasms | 1 | RGD |
umls:C0015230 | Exanthema | 1 | BeFree |
umls:C0015624 | Fanconi Syndrome | 1 | CTD_human |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | LHGDN |
umls:C0021655 | Insulin Resistance | 1 | CTD_human |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023895 | Liver diseases | 1 | GAD |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0038356 | Stomach Neoplasms | 1 | GAD |
umls:C0042487 | Venous Thrombosis | 1 | LHGDN |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C0151942 | Arterial thrombosis | 1 | BeFree |
umls:C0151945 | Thrombosis of cerebral veins | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0206681 | Adenocarcinoma, Clear Cell | 1 | LHGDN |
umls:C0206701 | Cystadenocarcinoma, Serous | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0848332 | Spots on skin | 1 | BeFree |
umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
umls:C1335177 | Ovarian Serous Adenocarcinoma | 1 | BeFree |
umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |