TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GRB14

Gene summary

Basic gene information	Gene symbol	GRB14
	Gene name	growth factor receptor-bound protein 14
	Synonyms	-
	Cytomap	UCSC genome browser: 2q22-q24
	Type of gene	protein-coding
	RefGenes	NM_004490.2,
	Description	GRB14 adapter protein
	Modification date	20141207
dbXrefs	MIM : 601524
	HGNC : HGNC
	Ensembl : ENSG00000115290
	HPRD : 03313
	Vega : OTTHUMG00000132135
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GRB14
	BioGPS: 2888
Pathway	NCI Pathway Interaction Database: GRB14
	KEGG: GRB14
	REACTOME: GRB14
	Pathway Commons: GRB14
Context	iHOP: GRB14
	ligand binding site mutation search in PubMed: GRB14
	UCL Cancer Institute: GRB14
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of GRB14
Description by TissGene annotations	Protective TissGene in OS Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for GRB14

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
THCA	0.394139647	1.485426088	-1.091286441	3.12E-10	1.95E-09
KIRP	2.528282868	4.141326618	-1.61304375	3.65E-06	1.64E-05
KIRC	1.64808009	4.155537034	-2.507456944	1.10E-22	1.06E-21
BLCA	-1.185456606	-2.397025027	1.211568421	0.011	0.047968627
COAD	-2.081390209	-0.618901748	-1.462488462	0.004	0.009858268

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TissGene-miRNA for GRB14

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for GRB14

TissGeneSNV for GRB14

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.A399V	PAAD	2
p.E84K	SKCM	2
p.E168K	SKCM	2
p.R451Q	ESCA	1
p.E327D	SARC	1
p.V133L	LUSC	1
p.E168K	UCEC	1
p.H167Y	SKCM	1
p.D287N	SKCM	1
p.S220F	SKCM	1
p.W149C	LUAD	1
p.F90I	COAD	1
p.R162K	SKCM	1
p.E402K	SKCM	1
p.R317Q	SARC	1
p.A192T	LUSC	1
p.D127G	UCEC	1
p.E394D	LUAD	1
p.S375F	SKCM	1
p.E182X	READ	1
p.G497C	OV	1
p.W149*	SKCM	1
p.K140N	UCEC	1
p.V93A	UCEC	1
p.C86*	UCEC	1
p.F488L	LIHC	1
p.H147Y	SKCM	1
p.M1I	STAD	1
p.Q363H	UCEC	1
p.P156S	COAD	1
p.P301L	UCEC	1
p.I224F	SKCM	1
p.E115K	BLCA	1
p.S271*	BLCA	1
p.P528S	SKCM	1
p.G299R	SKCM	1
p.S419I	STAD	1
p.W149X	SKCM	1
p.R105W	SKCM	1
p.Y202C	HNSC	1
p.K484N	UCEC	1
p.N349K	OV	1
p.M344I	UCEC	1
p.R275W	CESC	1
p.V290M	HNSC	1
p.N303K	LUSC	1
p.H242Y	BRCA	1
p.S261C	HNSC	1
p.H441Y	BLCA	1
p.W251*	LUSC	1
p.Q456R	ESCA	1
p.H442R	LUAD	1
p.K67M	OV	1
p.N183K	THYM	1
p.A405T	STAD	1
p.E214K	SKCM	1
p.K140N	PRAD	1
p.G497D	SKCM	1
p.G56R	KIRP	1
p.T129M	STAD	1
p.A23T	STAD	1
p.R275P	LUAD	1
p.R131G	BLCA	1
p.P81T	CHOL	1
p.S266A	SKCM	1
p.L85I	SARC	1
p.R275Q	UCEC	1
p.S426I	TGCT	1
p.E373K	CESC	1

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TissGeneCNV for GRB14

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for GRB14

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	DA571601	GRB14-GRB14		chr2:165358795	chr2:165404300

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TissGeneNet for GRB14

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

COAD (tumor)	COAD (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

HNSC (tumor)	HNSC (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

KICH (tumor)	KICH (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

KIRC (tumor)	KIRC (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

KIRP (tumor)	KIRP (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

LIHC (tumor)	LIHC (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

LUAD (tumor)	LUAD (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

LUSC (tumor)	LUSC (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

PRAD (tumor)	PRAD (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

STAD (tumor)	STAD (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

THCA (tumor)	THCA (normal)
GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (tumor)	GRB14, SQSTM1, SCN9A, NFKB1, MAP3K14, DAPK3, TEK, CDC5L, EGFR, IGF1R, IRS1, PDGFRB, INSR, PRKCZ, NRAS, FGFR1, TNKS2, PDGFRA, FTCD (normal)

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TissGeneProg for GRB14

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for GRB14

TissGeneDrug for GRB14

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for GRB14

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0006142	Malignant neoplasm of breast	2	BeFree
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	2	BeFree,CTD_human,GAD
umls:C0678222	Breast Carcinoma	2	BeFree
umls:C0007115	Malignant neoplasm of thyroid	1	BeFree
umls:C0027627	Neoplasm Metastasis	1	BeFree
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0043094	Weight Gain	1	CTD_human
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0699885	Carcinoma of bladder	1	BeFree
umls:C1520166	Xenograft Model	1	BeFree