TissGeneSummary for GRB14 |
Gene summary |
Basic gene information | Gene symbol | GRB14 |
Gene name | growth factor receptor-bound protein 14 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q22-q24 | |
Type of gene | protein-coding | |
RefGenes | NM_004490.2, | |
Description | GRB14 adapter protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 601524 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115290 | ||
HPRD : 03313 | ||
Vega : OTTHUMG00000132135 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GRB14 | |
BioGPS: 2888 | ||
Pathway | NCI Pathway Interaction Database: GRB14 | |
KEGG: GRB14 | ||
REACTOME: GRB14 | ||
Pathway Commons: GRB14 | ||
Context | iHOP: GRB14 | |
ligand binding site mutation search in PubMed: GRB14 | ||
UCL Cancer Institute: GRB14 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of GRB14 | ||
Description by TissGene annotations | Protective TissGene in OS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GRB14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.394139647 | 1.485426088 | -1.091286441 | 3.12E-10 | 1.95E-09 |
KIRP | 2.528282868 | 4.141326618 | -1.61304375 | 3.65E-06 | 1.64E-05 |
KIRC | 1.64808009 | 4.155537034 | -2.507456944 | 1.10E-22 | 1.06E-21 |
BLCA | -1.185456606 | -2.397025027 | 1.211568421 | 0.011 | 0.047968627 |
COAD | -2.081390209 | -0.618901748 | -1.462488462 | 0.004 | 0.009858268 |
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TissGene-miRNA for GRB14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GRB14 |
TissGeneSNV for GRB14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A399V | PAAD | 2 |
p.E84K | SKCM | 2 |
p.E168K | SKCM | 2 |
p.R451Q | ESCA | 1 |
p.E327D | SARC | 1 |
p.V133L | LUSC | 1 |
p.E168K | UCEC | 1 |
p.H167Y | SKCM | 1 |
p.D287N | SKCM | 1 |
p.S220F | SKCM | 1 |
p.W149C | LUAD | 1 |
p.F90I | COAD | 1 |
p.R162K | SKCM | 1 |
p.E402K | SKCM | 1 |
p.R317Q | SARC | 1 |
p.A192T | LUSC | 1 |
p.D127G | UCEC | 1 |
p.E394D | LUAD | 1 |
p.S375F | SKCM | 1 |
p.E182X | READ | 1 |
p.G497C | OV | 1 |
p.W149* | SKCM | 1 |
p.K140N | UCEC | 1 |
p.V93A | UCEC | 1 |
p.C86* | UCEC | 1 |
p.F488L | LIHC | 1 |
p.H147Y | SKCM | 1 |
p.M1I | STAD | 1 |
p.Q363H | UCEC | 1 |
p.P156S | COAD | 1 |
p.P301L | UCEC | 1 |
p.I224F | SKCM | 1 |
p.E115K | BLCA | 1 |
p.S271* | BLCA | 1 |
p.P528S | SKCM | 1 |
p.G299R | SKCM | 1 |
p.S419I | STAD | 1 |
p.W149X | SKCM | 1 |
p.R105W | SKCM | 1 |
p.Y202C | HNSC | 1 |
p.K484N | UCEC | 1 |
p.N349K | OV | 1 |
p.M344I | UCEC | 1 |
p.R275W | CESC | 1 |
p.V290M | HNSC | 1 |
p.N303K | LUSC | 1 |
p.H242Y | BRCA | 1 |
p.S261C | HNSC | 1 |
p.H441Y | BLCA | 1 |
p.W251* | LUSC | 1 |
p.Q456R | ESCA | 1 |
p.H442R | LUAD | 1 |
p.K67M | OV | 1 |
p.N183K | THYM | 1 |
p.A405T | STAD | 1 |
p.E214K | SKCM | 1 |
p.K140N | PRAD | 1 |
p.G497D | SKCM | 1 |
p.G56R | KIRP | 1 |
p.T129M | STAD | 1 |
p.A23T | STAD | 1 |
p.R275P | LUAD | 1 |
p.R131G | BLCA | 1 |
p.P81T | CHOL | 1 |
p.S266A | SKCM | 1 |
p.L85I | SARC | 1 |
p.R275Q | UCEC | 1 |
p.S426I | TGCT | 1 |
p.E373K | CESC | 1 |
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TissGeneCNV for GRB14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GRB14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA571601 | GRB14-GRB14 | chr2:165358795 | chr2:165404300 |
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TissGeneNet for GRB14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GRB14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GRB14 |
TissGeneDrug for GRB14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GRB14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree,CTD_human,GAD |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0043094 | Weight Gain | 1 | CTD_human |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |