TissGeneSummary for MRPL42 |
Gene summary |
Basic gene information | Gene symbol | MRPL42 |
Gene name | mitochondrial ribosomal protein L42 | |
Synonyms | L31MT|L42MT|MRP-L31|MRP-L42|MRP-S32|MRPL31|MRPS32|PTD007|RPML31|S32MT | |
Cytomap | UCSC genome browser: 12q22 | |
Type of gene | protein-coding | |
RefGenes | NM_014050.3, NM_172177.3,NR_038159.1,NR_038160.1,NR_038161.1, NM_172178.2, | |
Description | 28S ribosomal protein S32, mitochondrial39S ribosomal protein L31, mitochondrial39S ribosomal protein L42, mitochondrial | |
Modification date | 20141207 | |
dbXrefs | MIM : 611847 | |
HGNC : HGNC | ||
HPRD : 14761 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MRPL42 | |
BioGPS: 28977 | ||
Pathway | NCI Pathway Interaction Database: MRPL42 | |
KEGG: MRPL42 | ||
REACTOME: MRPL42 | ||
Pathway Commons: MRPL42 | ||
Context | iHOP: MRPL42 | |
ligand binding site mutation search in PubMed: MRPL42 | ||
UCL Cancer Institute: MRPL42 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
Reference showing the relevant tissue of MRPL42 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MRPL42 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for MRPL42 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MRPL42 |
TissGeneSNV for MRPL42 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q90L | LUAD | 1 |
p.S53Y | HNSC | 1 |
p.Y36F | LUAD | 1 |
p.M10I | LUAD | 1 |
p.P138S | SKCM | 1 |
p.H88D | OV | 1 |
p.E101* | OV | 1 |
p.P80S | SKCM | 1 |
p.A2T | UCEC | 1 |
p.S53C | UCEC | 1 |
p.E10Q | LUSC | 1 |
p.Q111K | LGG | 1 |
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TissGeneCNV for MRPL42 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MRPL42 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB133847 | MRPL42-ELL3 | chr12:93896276 | chr15:44084547 | |
Chimerdb3.0 | ChiTaRs | NA | BU742854 | CBFB-MRPL42 | chr16:67068103 | chr12:93881377 | |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A3M1-01A | MRPL42-NTN4 | 5'UTR-CDS | chr12:93861330 | chr12:96131922 |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A23R-01A | PLEKHG7-MRPL42 | Out-of-Frame | chr12:93135368 | chr12:93894951 |
Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7315-01A | CSDA-MRPL42 | Out-of-Frame | chr12:10875448 | chr12:93894951 |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A7EI-01A | MRPL42-FGD6 | In-Frame | chr12:93881436 | chr12:95475332 |
Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-EJ-7315-01A | YBX3-MRPL42 | Out-of-Frame | chr12:10875448 | chr12:93894951 |
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TissGeneNet for MRPL42 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MRPL42 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MRPL42 |
TissGeneDrug for MRPL42 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MRPL42 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |