TissGeneSummary for GRM3 |
Gene summary |
Basic gene information | Gene symbol | GRM3 |
Gene name | glutamate receptor, metabotropic 3 | |
Synonyms | GLUR3|GPRC1C|MGLUR3|mGlu3 | |
Cytomap | UCSC genome browser: 7q21.1-q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_000840.2, | |
Description | glutamate metabotropic receptor 3metabotropic glutamate receptor 3 | |
Modification date | 20141222 | |
dbXrefs | MIM : 601115 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198822 | ||
HPRD : 03070 | ||
Vega : OTTHUMG00000022884 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GRM3 | |
BioGPS: 2913 | ||
Pathway | NCI Pathway Interaction Database: GRM3 | |
KEGG: GRM3 | ||
REACTOME: GRM3 | ||
Pathway Commons: GRM3 | ||
Context | iHOP: GRM3 | |
ligand binding site mutation search in PubMed: GRM3 | ||
UCL Cancer Institute: GRM3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of GRM3 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GRM3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.845363518 | -0.343176018 | -1.5021875 | 1.67E-11 | 6.40E-11 |
KIRP | -2.075267337 | -0.734114212 | -1.341153125 | 1.33E-05 | 5.40E-05 |
LUAD | -2.239123049 | -0.779388566 | -1.459734483 | 2.62E-13 | 2.20E-12 |
LUSC | -2.028004286 | -0.892684678 | -1.135319608 | 4.16E-09 | 1.35E-08 |
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TissGene-miRNA for GRM3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-452-5p | MIMAT0001635 | 0.0029 | -0.39 | 56 |
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TissGeneMut for GRM3 |
TissGeneSNV for GRM3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E724K | SKCM | 5 |
p.M518I | SKCM | 4 |
p.E535K | SKCM | 3 |
p.G18E | SKCM | 3 |
p.E78K | SKCM | 2 |
p.G53R | SARC | 2 |
p.G53V | SARC | 2 |
p.S154F | SKCM | 2 |
p.R183C | GBM | 2 |
p.R64* | UCEC | 2 |
p.E49K | SKCM | 2 |
p.P342L | SKCM | 2 |
p.S657* | BLCA | 2 |
p.G462R | SKCM | 2 |
p.P46S | SKCM | 2 |
p.E538K | SKCM | 2 |
p.D221N | SKCM | 2 |
p.R465* | STAD | 2 |
p.T474A | SKCM | 2 |
p.P471S | SKCM | 2 |
p.P605L | SKCM | 2 |
p.D121N | SKCM | 2 |
p.A293T | HNSC | 2 |
p.A293D | HNSC | 2 |
p.D280N | SKCM | 2 |
p.G130E | SKCM | 2 |
p.E870K | SKCM | 2 |
p.G223E | SKCM | 2 |
p.D257N | SKCM | 2 |
p.E452K | SKCM | 1 |
p.R723W | UCEC | 1 |
p.G427E | SKCM | 1 |
p.V259L | BRCA | 1 |
p.L827V | LUSC | 1 |
p.F45Y | LUSC | 1 |
p.K358M | ESCA | 1 |
p.D194N | HNSC | 1 |
p.H519N | HNSC | 1 |
p.T864M | BRCA | 1 |
p.Q135* | SKCM | 1 |
p.A133S | ESCA | 1 |
p.G587V | LUSC | 1 |
p.A71V | SKCM | 1 |
p.D873N | PRAD | 1 |
p.V272M | STAD | 1 |
p.W529* | SKCM | 1 |
p.A507T | UCEC | 1 |
p.A288T | LAML | 1 |
p.R668H | COAD | 1 |
p.E767K | UCEC | 1 |
p.T800M | KICH | 1 |
p.T758M | GBM | 1 |
p.G514R | SKCM | 1 |
p.G475S | LUSC | 1 |
p.D194N | SKCM | 1 |
p.P342S | SKCM | 1 |
p.S610L | GBM | 1 |
p.E228K | CESC | 1 |
p.A71V | LUSC | 1 |
p.R68C | SARC | 1 |
p.D744N | SKCM | 1 |
p.D82N | SKCM | 1 |
p.W210* | SKCM | 1 |
p.D873N | SKCM | 1 |
p.K519T | STAD | 1 |
p.M400I | LUAD | 1 |
p.D221Y | BLCA | 1 |
p.D461H | BRCA | 1 |
p.G319S | SKCM | 1 |
p.E517* | UCEC | 1 |
p.Y212* | LUAD | 1 |
p.Q135X | SKCM | 1 |
p.M422I | SKCM | 1 |
p.N27T | STAD | 1 |
p.W303* | HNSC | 1 |
p.R371C | COAD | 1 |
p.F756L | LIHC | 1 |
p.Q338R | CHOL | 1 |
p.G18R | SKCM | 1 |
p.C513S | LAML | 1 |
p.W492* | SKCM | 1 |
p.L91F | HNSC | 1 |
p.A143E | LUAD | 1 |
p.R716K | SKCM | 1 |
p.S116Y | LGG | 1 |
p.R261Q | STAD | 1 |
p.R183C | SARC | 1 |
p.A158E | HNSC | 1 |
p.P638A | BRCA | 1 |
p.R759Q | UCEC | 1 |
p.D380N | COAD | 1 |
p.D542N | SKCM | 1 |
p.G319S | ESCA | 1 |
p.R6K | ESCA | 1 |
p.G58R | LUAD | 1 |
p.N345I | COAD | 1 |
p.R869Q | UCEC | 1 |
p.V835G | UCEC | 1 |
p.S637L | SKCM | 1 |
p.M518I | SARC | 1 |
p.Y318C | STAD | 1 |
p.H824Y | SKCM | 1 |
p.R759W | READ | 1 |
p.Q688R | STAD | 1 |
p.R352L | UCEC | 1 |
p.L96S | UCEC | 1 |
p.A677V | HNSC | 1 |
p.A16T | ESCA | 1 |
p.R668H | GBM | 1 |
p.R237H | ESCA | 1 |
p.H837N | HNSC | 1 |
p.D280H | ACC | 1 |
p.M521I | LUAD | 1 |
p.G312S | SKCM | 1 |
p.E262K | SKCM | 1 |
p.A115T | STAD | 1 |
p.E122K | SKCM | 1 |
p.I379M | LUSC | 1 |
p.E474K | BLCA | 1 |
p.R206C | ESCA | 1 |
p.I285T | HNSC | 1 |
p.T545S | LUSC | 1 |
p.R261Q | SKCM | 1 |
p.E32D | THYM | 1 |
p.G587V | ESCA | 1 |
p.I683T | KIRC | 1 |
p.N467S | LGG | 1 |
p.R465* | BRCA | 1 |
p.G65E | SKCM | 1 |
p.G848E | SKCM | 1 |
p.G676S | SKCM | 1 |
p.A609E | LIHC | 1 |
p.D873N | HNSC | 1 |
p.P863S | READ | 1 |
p.E233K | SKCM | 1 |
p.C502* | LUAD | 1 |
p.T211I | HNSC | 1 |
p.C692S | STAD | 1 |
p.R679K | ESCA | 1 |
p.R64Q | STAD | 1 |
p.S857F | SKCM | 1 |
p.L86I | ACC | 1 |
p.E228K | COAD | 1 |
p.G223R | HNSC | 1 |
p.K119R | UCEC | 1 |
p.R237P | LUSC | 1 |
p.R723W | SKCM | 1 |
p.P443L | SKCM | 1 |
p.A677S | HNSC | 1 |
p.P139Q | SKCM | 1 |
p.E385K | STAD | 1 |
p.R612Q | UCEC | 1 |
p.N341K | STAD | 1 |
p.F652V | STAD | 1 |
p.P685L | SKCM | 1 |
p.R261* | LGG | 1 |
p.A143T | LGG | 1 |
p.V823I | CESC | 1 |
p.S491L | UCEC | 1 |
p.A755S | KIRC | 1 |
p.V191M | ESCA | 1 |
p.A653T | STAD | 1 |
p.V271I | ACC | 1 |
p.T441M | LUAD | 1 |
p.E228K | SKCM | 1 |
p.R409H | GBM | 1 |
p.I530N | LUAD | 1 |
p.R409H | HNSC | 1 |
p.L29I | READ | 1 |
p.S740F | PAAD | 1 |
p.F359L | BLCA | 1 |
p.K366X | SKCM | 1 |
p.D102N | SKCM | 1 |
p.D121Y | LUAD | 1 |
p.E62K | ACC | 1 |
p.D525N | SKCM | 1 |
p.F770L | BLCA | 1 |
p.P128L | UCEC | 1 |
p.H518D | HNSC | 1 |
p.Q678K | LUAD | 1 |
p.P830L | SKCM | 1 |
p.F45L | SKCM | 1 |
p.F164L | LGG | 1 |
p.R30K | SKCM | 1 |
p.R162Q | UCS | 1 |
p.R183C | HNSC | 1 |
p.G772S | KIRP | 1 |
p.P329T | LUSC | 1 |
p.D257N | GBM | 1 |
p.E49K | SARC | 1 |
p.E111K | SKCM | 1 |
p.F682L | HNSC | 1 |
p.A269T | STAD | 1 |
p.G647R | HNSC | 1 |
p.R517* | SKCM | 1 |
p.G458S | SKCM | 1 |
p.T849A | STAD | 1 |
p.E219K | UCEC | 1 |
p.V191M | GBM | 1 |
p.D734Y | UCEC | 1 |
p.N345H | COAD | 1 |
p.P636L | SKCM | 1 |
p.D279E | HNSC | 1 |
p.W490* | SKCM | 1 |
p.T758M | STAD | 1 |
p.A305V | BLCA | 1 |
p.R206C | STAD | 1 |
p.R162Q | LGG | 1 |
p.E262* | UCEC | 1 |
p.L459P | SKCM | 1 |
p.Y171N | LUAD | 1 |
p.R371H | SKCM | 1 |
p.P193S | SKCM | 1 |
p.E203K | HNSC | 1 |
p.R352Q | SKCM | 1 |
p.R235H | READ | 1 |
p.A575T | LUAD | 1 |
p.G319D | SKCM | 1 |
p.E32G | HNSC | 1 |
p.G621V | COAD | 1 |
p.Y222C | BLCA | 1 |
p.S175R | HNSC | 1 |
p.M422V | LIHC | 1 |
p.E567* | HNSC | 1 |
p.V701L | LUSC | 1 |
p.R235H | PRAD | 1 |
p.R869Q | HNSC | 1 |
p.S610L | ESCA | 1 |
p.L41S | HNSC | 1 |
p.D548N | SKCM | 1 |
p.R668C | SKCM | 1 |
p.R797K | BLCA | 1 |
p.D180N | SKCM | 1 |
p.L559I | LUAD | 1 |
p.R237S | LUAD | 1 |
p.R59Q | SKCM | 1 |
p.I379S | OV | 1 |
p.D451H | HNSC | 1 |
p.W486R | ESCA | 1 |
p.K358T | STAD | 1 |
p.E231K | SKCM | 1 |
p.E488X | ESCA | 1 |
p.L559R | HNSC | 1 |
p.P533L | SKCM | 1 |
p.M589I | STAD | 1 |
p.A577V | PAAD | 1 |
p.E307K | SKCM | 1 |
p.T778M | LUAD | 1 |
p.Y318* | LUSC | 1 |
p.G476V | BRCA | 1 |
p.H496Y | LUAD | 1 |
p.E107X | CHOL | 1 |
p.S388Y | LUSC | 1 |
p.T98A | STAD | 1 |
p.P451S | HNSC | 1 |
p.P555T | LUAD | 1 |
p.W210X | SKCM | 1 |
p.G319S | HNSC | 1 |
p.P193L | SKCM | 1 |
p.K366* | SKCM | 1 |
p.D185H | LIHC | 1 |
p.R162W | PRAD | 1 |
p.R114K | KIRP | 1 |
p.R6I | UCEC | 1 |
p.G65R | HNSC | 1 |
p.K832N | KICH | 1 |
p.E107Q | LUAD | 1 |
p.F359L | STAD | 1 |
p.K254N | LUSC | 1 |
p.A176T | BRCA | 1 |
p.R371H | GBM | 1 |
p.S499T | BLCA | 1 |
p.P512T | KIRC | 1 |
p.W529X | SKCM | 1 |
p.L96F | HNSC | 1 |
p.E203Q | BRCA | 1 |
p.R465X | STAD | 1 |
p.E32* | UCEC | 1 |
p.S116F | SKCM | 1 |
p.S496T | OV | 1 |
p.G514R | ESCA | 1 |
p.S854A | LUSC | 1 |
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TissGeneCNV for GRM3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GRM3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF345337 | GRM3-ABCB1 | chr7:86331687 | chr7:87230325 | |
Chimerdb3.0 | FusionScan | SARC | TCGA-SI-A71O-01A | PCCA-GRM3 | In-Frame | chr13:101167821 | chr7:86415576 |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-4594-01A | DMTF1-GRM3 | Out-of-frame | Chr7:86794366 | Chr7:86415577 |
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TissGeneNet for GRM3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GRM3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GRM3 |
TissGeneDrug for GRM3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GRM3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 39 | BeFree,CTD_human,GAD,GWASCAT,LHGDN |
umls:C0005586 | Bipolar Disorder | 6 | BeFree,GAD |
umls:C0011570 | Mental Depression | 3 | BeFree |
umls:C0011581 | Depressive disorder | 3 | BeFree |
umls:C0033975 | Psychotic Disorders | 3 | BeFree |
umls:C0349204 | Nonorganic psychosis | 3 | BeFree |
umls:C0014038 | Encephalitis | 2 | BeFree |
umls:C0014544 | Epilepsy | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree,CTD_human |
umls:C0041696 | Unipolar Depression | 2 | BeFree |
umls:C0525045 | Mood Disorders | 2 | BeFree,GAD |
umls:C1269683 | Major Depressive Disorder | 2 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0007682 | CNS disorder | 1 | BeFree |
umls:C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
umls:C0017639 | Gliosis | 1 | LHGDN |
umls:C0019337 | Heroin Dependence | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0024809 | Marijuana Abuse | 1 | GAD |
umls:C0033941 | Psychoses, Substance-Induced | 1 | GAD |
umls:C0036337 | Schizoaffective Disorder | 1 | GAD |
umls:C0036572 | Seizures | 1 | BeFree |
umls:C0038580 | Substance Dependence | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0043094 | Weight Gain | 1 | GAD |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0393484 | Rasmussen Syndrome | 1 | BeFree |
umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
umls:C0746408 | mass lesion | 1 | BeFree |
umls:C1096063 | Drug Resistant Epilepsy | 1 | BeFree |
umls:C1510472 | Drug Dependence | 1 | BeFree |
umls:C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | BeFree |
umls:C1852197 | MAJOR AFFECTIVE DISORDER 1 | 1 | BeFree |
umls:C1970943 | MAJOR AFFECTIVE DISORDER 4 | 1 | BeFree |
umls:C1970944 | MAJOR AFFECTIVE DISORDER 5 | 1 | BeFree |
umls:C1970945 | MAJOR AFFECTIVE DISORDER 6 | 1 | BeFree |
umls:C2700438 | MAJOR AFFECTIVE DISORDER 7 | 1 | BeFree |
umls:C2700439 | MAJOR AFFECTIVE DISORDER 8 | 1 | BeFree |
umls:C2700440 | MAJOR AFFECTIVE DISORDER 9 | 1 | BeFree |
umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |