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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GRM3
check button Gene summary
Basic gene informationGene symbolGRM3
Gene nameglutamate receptor, metabotropic 3
SynonymsGLUR3|GPRC1C|MGLUR3|mGlu3
CytomapUCSC genome browser: 7q21.1-q21.2
Type of geneprotein-coding
RefGenesNM_000840.2,
Descriptionglutamate metabotropic receptor 3metabotropic glutamate receptor 3
Modification date20141222
dbXrefs MIM : 601115
HGNC : HGNC
Ensembl : ENSG00000198822
HPRD : 03070
Vega : OTTHUMG00000022884
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GRM3
BioGPS: 2913
PathwayNCI Pathway Interaction Database: GRM3
KEGG: GRM3
REACTOME: GRM3
Pathway Commons: GRM3
ContextiHOP: GRM3
ligand binding site mutation search in PubMed: GRM3
UCL Cancer Institute: GRM3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Brain
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGG
Reference showing the relevant tissue of GRM3
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for GRM3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-1.845363518-0.343176018-1.50218751.67E-116.40E-11
KIRP-2.075267337-0.734114212-1.3411531251.33E-055.40E-05
LUAD-2.239123049-0.779388566-1.4597344832.62E-132.20E-12
LUSC-2.028004286-0.892684678-1.1353196084.16E-091.35E-08


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TissGene-miRNA for GRM3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-452-5pMIMAT00016350.0029-0.3956


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TissGeneMut for GRM3
TissGeneSNV for GRM3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E724KSKCM5
p.M518ISKCM4
p.E535KSKCM3
p.G18ESKCM3
p.E78KSKCM2
p.G53RSARC2
p.G53VSARC2
p.S154FSKCM2
p.R183CGBM2
p.R64*UCEC2
p.E49KSKCM2
p.P342LSKCM2
p.S657*BLCA2
p.G462RSKCM2
p.P46SSKCM2
p.E538KSKCM2
p.D221NSKCM2
p.R465*STAD2
p.T474ASKCM2
p.P471SSKCM2
p.P605LSKCM2
p.D121NSKCM2
p.A293THNSC2
p.A293DHNSC2
p.D280NSKCM2
p.G130ESKCM2
p.E870KSKCM2
p.G223ESKCM2
p.D257NSKCM2
p.E452KSKCM1
p.R723WUCEC1
p.G427ESKCM1
p.V259LBRCA1
p.L827VLUSC1
p.F45YLUSC1
p.K358MESCA1
p.D194NHNSC1
p.H519NHNSC1
p.T864MBRCA1
p.Q135*SKCM1
p.A133SESCA1
p.G587VLUSC1
p.A71VSKCM1
p.D873NPRAD1
p.V272MSTAD1
p.W529*SKCM1
p.A507TUCEC1
p.A288TLAML1
p.R668HCOAD1
p.E767KUCEC1
p.T800MKICH1
p.T758MGBM1
p.G514RSKCM1
p.G475SLUSC1
p.D194NSKCM1
p.P342SSKCM1
p.S610LGBM1
p.E228KCESC1
p.A71VLUSC1
p.R68CSARC1
p.D744NSKCM1
p.D82NSKCM1
p.W210*SKCM1
p.D873NSKCM1
p.K519TSTAD1
p.M400ILUAD1
p.D221YBLCA1
p.D461HBRCA1
p.G319SSKCM1
p.E517*UCEC1
p.Y212*LUAD1
p.Q135XSKCM1
p.M422ISKCM1
p.N27TSTAD1
p.W303*HNSC1
p.R371CCOAD1
p.F756LLIHC1
p.Q338RCHOL1
p.G18RSKCM1
p.C513SLAML1
p.W492*SKCM1
p.L91FHNSC1
p.A143ELUAD1
p.R716KSKCM1
p.S116YLGG1
p.R261QSTAD1
p.R183CSARC1
p.A158EHNSC1
p.P638ABRCA1
p.R759QUCEC1
p.D380NCOAD1
p.D542NSKCM1
p.G319SESCA1
p.R6KESCA1
p.G58RLUAD1
p.N345ICOAD1
p.R869QUCEC1
p.V835GUCEC1
p.S637LSKCM1
p.M518ISARC1
p.Y318CSTAD1
p.H824YSKCM1
p.R759WREAD1
p.Q688RSTAD1
p.R352LUCEC1
p.L96SUCEC1
p.A677VHNSC1
p.A16TESCA1
p.R668HGBM1
p.R237HESCA1
p.H837NHNSC1
p.D280HACC1
p.M521ILUAD1
p.G312SSKCM1
p.E262KSKCM1
p.A115TSTAD1
p.E122KSKCM1
p.I379MLUSC1
p.E474KBLCA1
p.R206CESCA1
p.I285THNSC1
p.T545SLUSC1
p.R261QSKCM1
p.E32DTHYM1
p.G587VESCA1
p.I683TKIRC1
p.N467SLGG1
p.R465*BRCA1
p.G65ESKCM1
p.G848ESKCM1
p.G676SSKCM1
p.A609ELIHC1
p.D873NHNSC1
p.P863SREAD1
p.E233KSKCM1
p.C502*LUAD1
p.T211IHNSC1
p.C692SSTAD1
p.R679KESCA1
p.R64QSTAD1
p.S857FSKCM1
p.L86IACC1
p.E228KCOAD1
p.G223RHNSC1
p.K119RUCEC1
p.R237PLUSC1
p.R723WSKCM1
p.P443LSKCM1
p.A677SHNSC1
p.P139QSKCM1
p.E385KSTAD1
p.R612QUCEC1
p.N341KSTAD1
p.F652VSTAD1
p.P685LSKCM1
p.R261*LGG1
p.A143TLGG1
p.V823ICESC1
p.S491LUCEC1
p.A755SKIRC1
p.V191MESCA1
p.A653TSTAD1
p.V271IACC1
p.T441MLUAD1
p.E228KSKCM1
p.R409HGBM1
p.I530NLUAD1
p.R409HHNSC1
p.L29IREAD1
p.S740FPAAD1
p.F359LBLCA1
p.K366XSKCM1
p.D102NSKCM1
p.D121YLUAD1
p.E62KACC1
p.D525NSKCM1
p.F770LBLCA1
p.P128LUCEC1
p.H518DHNSC1
p.Q678KLUAD1
p.P830LSKCM1
p.F45LSKCM1
p.F164LLGG1
p.R30KSKCM1
p.R162QUCS1
p.R183CHNSC1
p.G772SKIRP1
p.P329TLUSC1
p.D257NGBM1
p.E49KSARC1
p.E111KSKCM1
p.F682LHNSC1
p.A269TSTAD1
p.G647RHNSC1
p.R517*SKCM1
p.G458SSKCM1
p.T849ASTAD1
p.E219KUCEC1
p.V191MGBM1
p.D734YUCEC1
p.N345HCOAD1
p.P636LSKCM1
p.D279EHNSC1
p.W490*SKCM1
p.T758MSTAD1
p.A305VBLCA1
p.R206CSTAD1
p.R162QLGG1
p.E262*UCEC1
p.L459PSKCM1
p.Y171NLUAD1
p.R371HSKCM1
p.P193SSKCM1
p.E203KHNSC1
p.R352QSKCM1
p.R235HREAD1
p.A575TLUAD1
p.G319DSKCM1
p.E32GHNSC1
p.G621VCOAD1
p.Y222CBLCA1
p.S175RHNSC1
p.M422VLIHC1
p.E567*HNSC1
p.V701LLUSC1
p.R235HPRAD1
p.R869QHNSC1
p.S610LESCA1
p.L41SHNSC1
p.D548NSKCM1
p.R668CSKCM1
p.R797KBLCA1
p.D180NSKCM1
p.L559ILUAD1
p.R237SLUAD1
p.R59QSKCM1
p.I379SOV1
p.D451HHNSC1
p.W486RESCA1
p.K358TSTAD1
p.E231KSKCM1
p.E488XESCA1
p.L559RHNSC1
p.P533LSKCM1
p.M589ISTAD1
p.A577VPAAD1
p.E307KSKCM1
p.T778MLUAD1
p.Y318*LUSC1
p.G476VBRCA1
p.H496YLUAD1
p.E107XCHOL1
p.S388YLUSC1
p.T98ASTAD1
p.P451SHNSC1
p.P555TLUAD1
p.W210XSKCM1
p.G319SHNSC1
p.P193LSKCM1
p.K366*SKCM1
p.D185HLIHC1
p.R162WPRAD1
p.R114KKIRP1
p.R6IUCEC1
p.G65RHNSC1
p.K832NKICH1
p.E107QLUAD1
p.F359LSTAD1
p.K254NLUSC1
p.A176TBRCA1
p.R371HGBM1
p.S499TBLCA1
p.P512TKIRC1
p.W529XSKCM1
p.L96FHNSC1
p.E203QBRCA1
p.R465XSTAD1
p.E32*UCEC1
p.S116FSKCM1
p.S496TOV1
p.G514RESCA1
p.S854ALUSC1


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TissGeneCNV for GRM3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for GRM3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAF345337GRM3-ABCB1chr7:86331687chr7:87230325
Chimerdb3.0FusionScanSARCTCGA-SI-A71O-01APCCA-GRM3In-Framechr13:101167821chr7:86415576
TCGAfusionPortalPRADALUSCTCGA-22-4594-01ADMTF1-GRM3Out-of-frameChr7:86794366Chr7:86415577


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TissGeneNet for GRM3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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COAD (tumor)COAD (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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HNSC (tumor)HNSC (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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KICH (tumor)KICH (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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KIRC (tumor)KIRC (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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KIRP (tumor)KIRP (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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LIHC (tumor)LIHC (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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LUAD (tumor)LUAD (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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LUSC (tumor)LUSC (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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PRAD (tumor)PRAD (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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STAD (tumor)STAD (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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THCA (tumor)THCA (normal)
GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (tumor)GRM3, CALM1, PICK1, GRIP1, PPM1A, SDCBP, GRASP (normal)
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TissGeneProg for GRM3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for GRM3
TissGeneDrug for GRM3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for GRM3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0036341Schizophrenia39BeFree,CTD_human,GAD,GWASCAT,LHGDN
umls:C0005586Bipolar Disorder6BeFree,GAD
umls:C0011570Mental Depression3BeFree
umls:C0011581Depressive disorder3BeFree
umls:C0033975Psychotic Disorders3BeFree
umls:C0349204Nonorganic psychosis3BeFree
umls:C0014038Encephalitis2BeFree
umls:C0014544Epilepsy2BeFree
umls:C0017638Glioma2BeFree
umls:C0025202melanoma2BeFree,CTD_human
umls:C0041696Unipolar Depression2BeFree
umls:C0525045Mood Disorders2BeFree,GAD
umls:C1269683Major Depressive Disorder2BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0007682CNS disorder1BeFree
umls:C0014556Epilepsy, Temporal Lobe1CTD_human
umls:C0017639Gliosis1LHGDN
umls:C0019337Heroin Dependence1BeFree
umls:C0023418leukemia1BeFree
umls:C0024131Lupus Vulgaris1BeFree
umls:C0024138Lupus Erythematosus, Discoid1BeFree
umls:C0024141Lupus Erythematosus, Systemic1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024809Marijuana Abuse1GAD
umls:C0033941Psychoses, Substance-Induced1GAD
umls:C0036337Schizoaffective Disorder1GAD
umls:C0036572Seizures1BeFree
umls:C0038580Substance Dependence1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0043094Weight Gain1GAD
umls:C0338656Impaired cognition1BeFree
umls:C0393484Rasmussen Syndrome1BeFree
umls:C0409974Lupus Erythematosus1BeFree
umls:C0746408mass lesion1BeFree
umls:C1096063Drug Resistant Epilepsy1BeFree
umls:C1510472Drug Dependence1BeFree
umls:C1839839MAJOR AFFECTIVE DISORDER 21BeFree
umls:C1852197MAJOR AFFECTIVE DISORDER 11BeFree
umls:C1970943MAJOR AFFECTIVE DISORDER 41BeFree
umls:C1970944MAJOR AFFECTIVE DISORDER 51BeFree
umls:C1970945MAJOR AFFECTIVE DISORDER 61BeFree
umls:C2700438MAJOR AFFECTIVE DISORDER 71BeFree
umls:C2700439MAJOR AFFECTIVE DISORDER 81BeFree
umls:C2700440MAJOR AFFECTIVE DISORDER 91BeFree
umls:C2911647Weight Gain Adverse Event1GAD