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| TissGeneSummary for GRM8 |
 Gene summary |
| Basic gene information | Gene symbol | GRM8 |
| Gene name | glutamate receptor, metabotropic 8 | |
| Synonyms | GLUR8|GPRC1H|MGLUR8|mGlu8 | |
| Cytomap | UCSC genome browser: 7q31.3-q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000845.2, NM_001127323.1,NR_028041.1, | |
| Description | metabotropic glutamate receptor 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601116 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000179603 | ||
| HPRD : 03071 | ||
| Vega : OTTHUMG00000022888 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GRM8 | |
| BioGPS: 2918 | ||
| Pathway | NCI Pathway Interaction Database: GRM8 | |
| KEGG: GRM8 | ||
| REACTOME: GRM8 | ||
| Pathway Commons: GRM8 | ||
| Context | iHOP: GRM8 | |
| ligand binding site mutation search in PubMed: GRM8 | ||
| UCL Cancer Institute: GRM8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADTGCT | |
| Reference showing the relevant tissue of GRM8 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0030818 | negative regulation of cAMP biosynthetic process | 11166323 | GO:0030818 | negative regulation of cAMP biosynthetic process | 11166323 |
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| TissGeneExp for GRM8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 4.088968994 | 2.240188438 | 1.848780556 | 2.39E-12 | 9.92E-12 |
| BRCA | 0.649753497 | -1.749771065 | 2.399524561 | 1.68E-40 | 5.26E-39 |
| LIHC | -0.374361451 | 2.636304549 | -3.010666 | 2.91E-11 | 4.17E-10 |
| STAD | 0.609299549 | -1.451331701 | 2.06063125 | 4.96E-09 | 2.86E-07 |
| KICH | 1.085136549 | 2.328172549 | -1.243036 | 0.00278 | 0.005544905 |
| KIRP | 3.833052674 | 2.122165174 | 1.7108875 | 3.68E-05 | 0.0001382 |
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| TissGene-miRNA for GRM8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GRM8 |
| TissGeneSNV for GRM8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S908F | SKCM | 4 |
| p.Q320* | SKCM | 3 |
| p.V624L | LUAD | 2 |
| p.E620K | SKCM | 2 |
| p.S662R | ESCA | 2 |
| p.S219L | SKCM | 2 |
| p.S823G | STAD | 2 |
| p.G50D | HNSC | 2 |
| p.R348Q | SKCM | 2 |
| p.G873E | SKCM | 2 |
| p.E365D | UCEC | 2 |
| p.R852C | LIHC | 2 |
| p.S894F | SKCM | 2 |
| p.S649F | SKCM | 2 |
| p.E70K | SKCM | 2 |
| p.Q320X | SKCM | 2 |
| p.V478A | SKCM | 1 |
| p.K370R | SKCM | 1 |
| p.H674Y | SKCM | 1 |
| p.P845L | SKCM | 1 |
| p.E271Q | ESCA | 1 |
| p.G244V | LUAD | 1 |
| p.R30I | UCEC | 1 |
| p.R240M | UCEC | 1 |
| p.P774T | LUAD | 1 |
| p.I901V | LUAD | 1 |
| p.G439V | UCEC | 1 |
| p.R566L | SARC | 1 |
| p.T730I | LUAD | 1 |
| p.E66* | HNSC | 1 |
| p.N671Y | LUAD | 1 |
| p.Q494* | SKCM | 1 |
| p.S497F | CESC | 1 |
| p.L833R | UCEC | 1 |
| p.F637I | COAD | 1 |
| p.I428T | LUAD | 1 |
| p.M639I | ESCA | 1 |
| p.G368C | LIHC | 1 |
| p.P587R | LUAD | 1 |
| p.R652L | LUAD | 1 |
| p.L98Q | LUAD | 1 |
| p.P512A | DLBC | 1 |
| p.V624M | SKCM | 1 |
| p.F637I | HNSC | 1 |
| p.T528M | GBM | 1 |
| p.G754E | STAD | 1 |
| p.F367Y | SKCM | 1 |
| p.P468A | CESC | 1 |
| p.W305C | ACC | 1 |
| p.D743N | SKCM | 1 |
| p.A391P | HNSC | 1 |
| p.L16F | SKCM | 1 |
| p.H32Y | ESCA | 1 |
| p.D472N | SKCM | 1 |
| p.T220S | LUAD | 1 |
| p.R447W | CESC | 1 |
| p.W358C | THYM | 1 |
| p.E224Q | LUAD | 1 |
| p.F461S | TGCT | 1 |
| p.R354Q | SKCM | 1 |
| p.A408V | HNSC | 1 |
| p.Q850E | BLCA | 1 |
| p.T528M | PAAD | 1 |
| p.S823R | STAD | 1 |
| p.T645K | STAD | 1 |
| p.R729W | LAML | 1 |
| p.R343Q | SKCM | 1 |
| p.R540S | LUAD | 1 |
| p.S691F | LUAD | 1 |
| p.S683Y | LGG | 1 |
| p.S395F | PAAD | 1 |
| p.Y227* | PRAD | 1 |
| p.S691I | LUAD | 1 |
| p.A863S | HNSC | 1 |
| p.R75I | COAD | 1 |
| p.E365V | LUAD | 1 |
| p.S394P | READ | 1 |
| p.S694Y | SKCM | 1 |
| p.R101C | STAD | 1 |
| p.R672H | STAD | 1 |
| p.C3* | LUAD | 1 |
| p.K68N | CESC | 1 |
| p.D422V | HNSC | 1 |
| p.L93F | SKCM | 1 |
| p.G879S | SKCM | 1 |
| p.R566S | LUSC | 1 |
| p.E890K | SKCM | 1 |
| p.Y189D | STAD | 1 |
| p.R876I | STAD | 1 |
| p.Q321H | KIRC | 1 |
| p.G754* | UCEC | 1 |
| p.E880K | STAD | 1 |
| p.L387M | LUSC | 1 |
| p.L416M | LUAD | 1 |
| p.I315L | SARC | 1 |
| p.R343Q | UCEC | 1 |
| p.R540H | HNSC | 1 |
| p.A665D | LUSC | 1 |
| p.A505V | SKCM | 1 |
| p.W713* | BRCA | 1 |
| p.S219L | UCEC | 1 |
| p.V838I | SKCM | 1 |
| p.T31A | UCEC | 1 |
| p.R852L | LUAD | 1 |
| p.V614M | COAD | 1 |
| p.I842F | HNSC | 1 |
| p.R389Q | SKCM | 1 |
| p.N298S | HNSC | 1 |
| p.A467S | LUAD | 1 |
| p.P198T | SKCM | 1 |
| p.G149V | ACC | 1 |
| p.H496Y | SKCM | 1 |
| p.E554D | LUSC | 1 |
| p.V601L | LUSC | 1 |
| p.S581Y | LUAD | 1 |
| p.K296T | COAD | 1 |
| p.A597T | UCEC | 1 |
| p.R354Q | BLCA | 1 |
| p.S756N | STAD | 1 |
| p.P425H | ACC | 1 |
| p.S691C | LUAD | 1 |
| p.R470L | LUAD | 1 |
| p.G426E | SKCM | 1 |
| p.P254Q | LUAD | 1 |
| p.S825R | STAD | 1 |
| p.P719S | SKCM | 1 |
| p.R651Q | COAD | 1 |
| p.K837R | SKCM | 1 |
| p.N216D | UCEC | 1 |
| p.R354Q | READ | 1 |
| p.G568R | LUAD | 1 |
| p.I646N | ESCA | 1 |
| p.S373* | STAD | 1 |
| p.K382N | UCEC | 1 |
| p.N450H | UCS | 1 |
| p.L51F | SKCM | 1 |
| p.R41Q | ESCA | 1 |
| p.N450H | READ | 1 |
| p.P900L | LUAD | 1 |
| p.T699N | LUAD | 1 |
| p.S902I | LUAD | 1 |
| p.Q202E | HNSC | 1 |
| p.C648F | LUAD | 1 |
| p.A862P | LUAD | 1 |
| p.R566S | HNSC | 1 |
| p.G873R | SKCM | 1 |
| p.Q237* | SKCM | 1 |
| p.K143* | BLCA | 1 |
| p.C569F | LUAD | 1 |
| p.D145N | UCEC | 1 |
| p.T528M | STAD | 1 |
| p.R433Q | READ | 1 |
| p.A128P | LUSC | 1 |
| p.S230N | HNSC | 1 |
| p.E887K | SKCM | 1 |
| p.D185N | SKCM | 1 |
| p.S411F | SKCM | 1 |
| p.G260A | CESC | 1 |
| p.E578K | SKCM | 1 |
| p.C541S | PAAD | 1 |
| p.G312V | UCS | 1 |
| p.P573L | SKCM | 1 |
| p.E77K | LIHC | 1 |
| p.G489S | HNSC | 1 |
| p.A19S | STAD | 1 |
| p.W713C | LUSC | 1 |
| p.A122T | STAD | 1 |
| p.F451C | STAD | 1 |
| p.H380Y | BLCA | 1 |
| p.H511P | LUAD | 1 |
| p.I842F | STAD | 1 |
| p.R355S | ESCA | 1 |
| p.S219L | OV | 1 |
| p.T786A | UCEC | 1 |
| p.A128S | HNSC | 1 |
| p.K903N | TGCT | 1 |
| p.L749F | COAD | 1 |
| p.K894E | ACC | 1 |
| p.K401N | SKCM | 1 |
| p.R566H | BRCA | 1 |
| p.F637L | COAD | 1 |
| p.Q398H | LUSC | 1 |
| p.L558P | SKCM | 1 |
| p.P719L | STAD | 1 |
| p.D104H | HNSC | 1 |
| p.I315L | ESCA | 1 |
| p.R433Q | SKCM | 1 |
| p.G228D | SKCM | 1 |
| p.Q249L | LUSC | 1 |
| p.E620K | BLCA | 1 |
| p.P533S | SKCM | 1 |
| p.E463K | SKCM | 1 |
| p.L818R | BLCA | 1 |
| p.G368V | LIHC | 1 |
| p.R433Q | LGG | 1 |
| p.P562R | LIHC | 1 |
| p.C246F | SKCM | 1 |
| p.L631F | SKCM | 1 |
| p.G465V | ESCA | 1 |
| p.Y725N | HNSC | 1 |
| p.S454N | UCEC | 1 |
| p.H38N | ESCA | 1 |
| p.R30K | CHOL | 1 |
| p.R433Q | GBM | 1 |
| p.E887D | BLCA | 1 |
| p.V120L | LUSC | 1 |
| p.S159F | SKCM | 1 |
| p.G152R | GBM | 1 |
| p.F677S | GBM | 1 |
| p.G469E | SKCM | 1 |
| p.I381V | CESC | 1 |
| p.E233K | HNSC | 1 |
| p.A584T | SARC | 1 |
| p.S10F | BLCA | 1 |
| p.V684I | LUAD | 1 |
| p.V42L | LUAD | 1 |
| p.R343G | UCEC | 1 |
| p.W23C | MESO | 1 |
| p.V232L | LUAD | 1 |
| p.S499N | SKCM | 1 |
| p.L93P | SKCM | 1 |
| p.G214R | SKCM | 1 |
| p.L621P | STAD | 1 |
| p.T770R | SKCM | 1 |
| p.Y344X | LIHC | 1 |
| p.I446T | LIHC | 1 |
| p.R354Q | GBM | 1 |
| p.N274H | BRCA | 1 |
| p.S855N | HNSC | 1 |
| p.I102V | ESCA | 1 |
| p.L708H | STAD | 1 |
| p.L213M | LUAD | 1 |
| p.L518Q | LUAD | 1 |
| p.S219L | LUAD | 1 |
| p.L666F | SKCM | 1 |
| p.R672H | HNSC | 1 |
| p.Y725C | LUSC | 1 |
| p.A415V | LUAD | 1 |
| p.R167I | UCEC | 1 |
| p.S894P | LIHC | 1 |
| p.Y755C | LUSC | 1 |
| p.C569X | COAD | 1 |
| p.L183I | SARC | 1 |
| p.S200F | SARC | 1 |
| p.Q679K | STAD | 1 |
| p.G531E | LUAD | 1 |
| p.G784R | SKCM | 1 |
| p.G905R | ESCA | 1 |
| p.E256K | SKCM | 1 |
| p.N848Y | LUAD | 1 |
| p.F777L | KICH | 1 |
| p.E484K | SKCM | 1 |
| p.M28I | UCEC | 1 |
| p.K682E | PRAD | 1 |
| p.R377K | SKCM | 1 |
| p.Q475K | READ | 1 |
| p.C64W | OV | 1 |
| p.D339H | LUSC | 1 |
| p.I798N | SKCM | 1 |
| p.R348* | LUAD | 1 |
| p.R194X | PAAD | 1 |
| p.K857T | STAD | 1 |
| p.V614L | LGG | 1 |
| p.R194* | PAAD | 1 |
| p.G628R | SKCM | 1 |
| p.L117V | STAD | 1 |
| p.S310I | COAD | 1 |
| p.S883I | LUAD | 1 |
| p.R276* | SKCM | 1 |
| p.P643T | OV | 1 |
| p.I793V | HNSC | 1 |
| p.S907* | BRCA | 1 |
| p.G465R | GBM | 1 |
| p.S129L | SKCM | 1 |
| p.N452K | ESCA | 1 |
| p.G594E | SKCM | 1 |
| p.Q320H | LUAD | 1 |
| p.G531R | SKCM | 1 |
| p.A686V | LAML | 1 |
| p.H420R | SKCM | 1 |
| p.I171T | LIHC | 1 |
| p.E361K | SKCM | 1 |
| p.Q321E | LUAD | 1 |
| p.R607L | LUAD | 1 |
| p.K146N | UCEC | 1 |
| p.N563I | HNSC | 1 |
| p.T786P | OV | 1 |
| p.R675Q | SKCM | 1 |
| p.S821F | HNSC | 1 |
| p.G136E | SKCM | 1 |
| p.A19V | UCEC | 1 |
| p.I757V | LUAD | 1 |
| p.K872N | SKCM | 1 |
| p.S373X | STAD | 1 |
| p.E620K | READ | 1 |
| p.V653L | LUSC | 1 |
| p.H674Q | LUAD | 1 |
| p.A858V | SKCM | 1 |
| p.S581F | SKCM | 1 |
| p.K267Q | SKCM | 1 |
| p.E364K | SKCM | 1 |
| p.S156R | SARC | 1 |
| p.V653D | SARC | 1 |
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| TissGeneCNV for GRM8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GRM8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI267717 | GRM8-KCNQ5 | chr7:126717987 | chr6:73356962 | |
| Chimerdb3.0 | ChiTaRs | NA | EL582588 | GRM8-GRM8 | chr7:126860910 | chr7:126860978 | |
| Chimerdb3.0 | ChiTaRs | NA | BF893584 | GRM8-GANAB | chr7:126524998 | chr11:62392486 | |
| Chimerdb3.0 | ChiTaRs | NA | EL585323 | GRM8-GRM8 | chr7:126861322 | chr7:126860852 | |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A6BH-01A | CPSF6-GRM8 | 3'UTR-3'UTR | chr12:69656342 | chr7:126746766 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A1-A0SN-01A | SND1-GRM8 | Out-of-frame | Chr7:127361454 | Chr7:126544737 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-39-5011-01A | HIPK2-GRM8 | Out-of-frame | Chr7:139285163 | Chr7:126249552 |
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| TissGeneNet for GRM8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (tumor) | GRM8, FLNA, GPRASP1, PIAS2, PIAS1 (normal) |
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| TissGeneProg for GRM8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GRM8 |
| TissGeneDrug for GRM8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GRM8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 4 | BeFree,GAD |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | BeFree,GAD |
| umls:C0004352 | Autistic Disorder | 2 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0036572 | Seizures | 2 | BeFree,RGD |
| umls:C1263846 | Attention deficit hyperactivity disorder | 2 | BeFree,CTD_human |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree,CTD_human |
| umls:C0004936 | Mental disorders | 1 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0014544 | Epilepsy | 1 | BeFree,RGD |
| umls:C0017639 | Gliosis | 1 | CTD_human |
| umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
| umls:C0019337 | Heroin Dependence | 1 | GAD |
| umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| umls:C0242422 | Parkinsonian Disorders | 1 | RGD |
| umls:C0524528 | Pervasive Development Disorder | 1 | BeFree,GAD |
| umls:C0524662 | Opiate Addiction | 1 | BeFree |
| umls:C0586323 | Alcohol Withdrawal Seizures | 1 | GAD |
| umls:C1852467 | Creutzfeldt-Jakob Disease, Sporadic | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
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