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| TissGeneSummary for CXCL2 |
 Gene summary |
| Basic gene information | Gene symbol | CXCL2 |
| Gene name | chemokine (C-X-C motif) ligand 2 | |
| Synonyms | CINC-2a|GRO2|GROb|MGSA-b|MIP-2a|MIP2|MIP2A|SCYB2 | |
| Cytomap | UCSC genome browser: 4q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002089.3, | |
| Description | C-X-C motif chemokine 2GRO2 oncogeneMGSA betaMIP2-alphagro-betagrowth-regulated protein betamacrophage inflammatory protein 2-alphamelanoma growth stimulatory activity beta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 139110 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000081041 | ||
| HPRD : 00741 | ||
| Vega : OTTHUMG00000160865 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CXCL2 | |
| BioGPS: 2920 | ||
| Pathway | NCI Pathway Interaction Database: CXCL2 | |
| KEGG: CXCL2 | ||
| REACTOME: CXCL2 | ||
| Pathway Commons: CXCL2 | ||
| Context | iHOP: CXCL2 | |
| ligand binding site mutation search in PubMed: CXCL2 | ||
| UCL Cancer Institute: CXCL2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CXCL2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0002237 | response to molecule of bacterial origin | 19912257 | GO:0002237 | response to molecule of bacterial origin | 19912257 |
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| TissGeneExp for CXCL2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.208879626 | 5.58358943 | -4.374709804 | 1.01E-17 | 8.88E-17 |
| LIHC | 2.35515692 | 5.37238092 | -3.017224 | 2.96E-14 | 8.02E-13 |
| LUAD | 2.563661472 | 5.089068368 | -2.525406897 | 9.66E-12 | 6.75E-11 |
| KICH | -3.57205708 | 0.32332692 | -3.895384 | 1.55E-12 | 1.80E-11 |
| BRCA | -1.943111396 | 2.789151762 | -4.732263158 | 7.06E-57 | 1.77E-54 |
| KIRP | -0.749694455 | 0.27368992 | -1.023384375 | 0.0106 | 0.023185561 |
| COAD | 1.864699535 | 0.490349535 | 1.37435 | 0.0015 | 0.004128769 |
| HNSC | -0.078496708 | 1.39697306 | -1.475469767 | 0.00056 | 0.002062193 |
| BLCA | -0.13768508 | 2.645546499 | -2.783231579 | 1.00E-04 | 0.00110099 |
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| TissGene-miRNA for CXCL2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CXCL2 |
| TissGeneSNV for CXCL2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T48I | STAD | 1 |
| p.E98K | UCEC | 1 |
| p.A38V | BLCA | 1 |
| p.Q50R | UCEC | 1 |
| p.H53Y | HNSC | 1 |
| p.L78F | STAD | 1 |
| p.E98* | LUAD | 1 |
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| TissGeneCNV for CXCL2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CXCL2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CXCL2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| COAD (tumor) | COAD (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| KICH (tumor) | KICH (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| STAD (tumor) | STAD (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| THCA (tumor) | THCA (normal) |
| CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (tumor) | CXCL2, RELA, COPS5, PIK3R1, PLG, EPS8, DPP4, CXCR1, IL8, CXCR2, PIK3R5 (normal) |
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| TissGeneProg for CXCL2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CXCL2 |
| TissGeneDrug for CXCL2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CXCL2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024115 | Lung diseases | 6 | BeFree,RGD |
| umls:C0035126 | Reperfusion Injury | 4 | CTD_human,RGD |
| umls:C0025202 | melanoma | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree,LHGDN |
| umls:C0032285 | Pneumonia | 3 | BeFree,RGD |
| umls:C0026946 | Mycoses | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree,CTD_human |
| umls:C0036690 | Septicemia | 2 | BeFree |
| umls:C0243026 | Sepsis | 2 | BeFree,GAD,LHGDN |
| umls:C1458155 | Mammary Neoplasms | 2 | CTD_human,LHGDN |
| umls:C1719672 | Severe Sepsis | 2 | BeFree |
| umls:C0000880 | Acanthamoeba Keratitis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0004626 | Pneumonia, Bacterial | 1 | RGD |
| umls:C0005974 | Bone Resorption | 1 | CTD_human |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
| umls:C0008370 | Cholestasis | 1 | CTD_human |
| umls:C0008372 | Intrahepatic Cholestasis | 1 | RGD |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0013371 | Shigella Infections | 1 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0017919 | Glycogen Storage Disease | 1 | LHGDN |
| umls:C0018801 | Heart failure | 1 | CTD_human |
| umls:C0019080 | Hemorrhage | 1 | RGD |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0019188 | Hepatitis, Animal | 1 | RGD |
| umls:C0019693 | HIV Infections | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | CTD_human |
| umls:C0021368 | Inflammation | 1 | CTD_human |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0023896 | Alcoholic Liver Diseases | 1 | RGD |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027055 | Myocardial Reperfusion Injury | 1 | RGD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | RGD |
| umls:C0032231 | Pleurisy | 1 | RGD |
| umls:C0032290 | Aspiration Pneumonia | 1 | RGD |
| umls:C0032310 | Pneumonia, Viral | 1 | RGD |
| umls:C0034063 | Pulmonary Edema | 1 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
| umls:C0037274 | Dermatologic disorders | 1 | CTD_human |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | CTD_human |
| umls:C0153252 | Systemic candidiasis | 1 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0206750 | Coronavirus Infections | 1 | RGD |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0242488 | Acute Lung Injury | 1 | RGD |
| umls:C0267941 | Pancreatitis, Acute Necrotizing | 1 | RGD |
| umls:C0311375 | Arsenic Poisoning | 1 | CTD_human |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0410808 | Prosthetic joint infection | 1 | BeFree |
| umls:C0520575 | Acute pyelonephritis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| umls:C0860564 | Retinoic acid syndrome | 1 | BeFree |
| umls:C0876973 | Infectious disease of lung | 1 | BeFree |
| umls:C1527311 | Brain Edema | 1 | RGD |
| umls:C2145472 | Urothelial Carcinoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3179349 | Gastrointestinal Stromal Sarcoma | 1 | BeFree |
| umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |
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