TissGeneSummary for CYP2S1 |
Gene summary |
Basic gene information | Gene symbol | CYP2S1 |
Gene name | cytochrome P450, family 2, subfamily S, polypeptide 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_030622.6, | |
Description | CYPIIS1cytochrome P450 2S1cytochrome P450 family member predicted from ESTscytochrome P540, subfamily IIS, polypeptide 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611529 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167600 | ||
HPRD : 07481 | ||
Vega : OTTHUMG00000182721 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYP2S1 | |
BioGPS: 29785 | ||
Pathway | NCI Pathway Interaction Database: CYP2S1 | |
KEGG: CYP2S1 | ||
REACTOME: CYP2S1 | ||
Pathway Commons: CYP2S1 | ||
Context | iHOP: CYP2S1 | |
ligand binding site mutation search in PubMed: CYP2S1 | ||
UCL Cancer Institute: CYP2S1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSTAD | |
Reference showing the relevant tissue of CYP2S1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CYP2S1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.278886346 | -0.808174346 | -2.470712 | 9.12E-07 | 3.44E-06 |
LUSC | 3.034165576 | 1.544557733 | 1.489607843 | 7.74E-06 | 1.78E-05 |
THCA | 0.499495553 | -2.804970549 | 3.304466102 | 7.51E-17 | 1.35E-15 |
COAD | 4.46019627 | 2.91854627 | 1.54165 | 1.91E-07 | 1.27E-06 |
Top |
TissGene-miRNA for CYP2S1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CYP2S1 |
TissGeneSNV for CYP2S1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A105V | COAD | 1 |
p.D112H | BLCA | 1 |
p.F130I | SKCM | 1 |
p.L357M | UCEC | 1 |
p.A151V | LGG | 1 |
p.T501M | UCEC | 1 |
p.G207R | PRAD | 1 |
p.S462F | SKCM | 1 |
p.G141E | SKCM | 1 |
p.V252M | SKCM | 1 |
p.G303W | LUSC | 1 |
p.R382Q | KIRP | 1 |
p.G216E | SARC | 1 |
p.R88L | SKCM | 1 |
p.N483S | STAD | 1 |
p.P167L | SKCM | 1 |
p.R250W | STAD | 1 |
p.P494L | SKCM | 1 |
p.A265T | UCEC | 1 |
p.G257E | ESCA | 1 |
p.P77S | STAD | 1 |
p.S214F | SKCM | 1 |
p.E221K | SKCM | 1 |
p.G339D | SKCM | 1 |
p.T306M | BRCA | 1 |
p.S262L | SKCM | 1 |
p.D112V | STAD | 1 |
p.G211R | SKCM | 1 |
p.G121R | UCEC | 1 |
p.M222I | PAAD | 1 |
p.R166H | PRAD | 1 |
p.G121E | SKCM | 1 |
p.A265T | LUAD | 1 |
p.N258H | SKCM | 1 |
p.R362Q | CHOL | 1 |
p.R228Q | STAD | 1 |
p.T501M | COAD | 1 |
p.R377Q | UCEC | 1 |
p.R166C | PAAD | 1 |
p.V311F | UCS | 1 |
p.L259M | LIHC | 1 |
p.M319I | SKCM | 1 |
p.R123W | UCEC | 1 |
p.A177V | STAD | 1 |
p.P322L | SKCM | 1 |
p.G100S | GBM | 1 |
p.G100S | COAD | 1 |
p.V80I | SKCM | 1 |
p.H498Y | SKCM | 1 |
p.I371K | COAD | 1 |
p.T501R | HNSC | 1 |
p.D195N | SKCM | 1 |
p.R88Q | STAD | 1 |
p.P403S | BLCA | 1 |
p.S479R | LUAD | 1 |
p.E164K | BRCA | 1 |
p.H408Q | BRCA | 1 |
p.D270N | COAD | 1 |
p.L72M | UCEC | 1 |
p.P432L | SKCM | 1 |
p.S99G | UCEC | 1 |
p.V67M | SKCM | 1 |
p.G217S | MESO | 1 |
Top |
TissGeneCNV for CYP2S1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CYP2S1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF878278 | CAPN5-CYP2S1 | chr11:76835295 | chr19:41711957 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A147-01A | VASP-CYP2S1 | Out-of-frame | Chr19:46011034 | Chr19:41711863 |
Top |
TissGeneNet for CYP2S1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CYP2S1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CYP2S1 |
TissGeneDrug for CYP2S1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CYP2S1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0033860 | Psoriasis | 1 | BeFree,CTD_human |
umls:C0037274 | Dermatologic disorders | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |