TissGeneSummary for SENP1 |
Gene summary |
Basic gene information | Gene symbol | SENP1 |
Gene name | SUMO1/sentrin specific peptidase 1 | |
Synonyms | SuPr-2 | |
Cytomap | UCSC genome browser: 12q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001267594.1, NM_001267595.1,NR_051991.1,NR_051992.1,NM_014554.2, | |
Description | SUMO1/sentrin specific protease 1sentrin-specific protease 1sentrin/SUMO-specific protease SENP1 | |
Modification date | 20141222 | |
dbXrefs | MIM : 612157 | |
HGNC : HGNC | ||
Ensembl : ENSG00000079387 | ||
HPRD : 07153 | ||
Vega : OTTHUMG00000169896 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SENP1 | |
BioGPS: 29843 | ||
Pathway | NCI Pathway Interaction Database: SENP1 | |
KEGG: SENP1 | ||
REACTOME: SENP1 | ||
Pathway Commons: SENP1 | ||
Context | iHOP: SENP1 | |
ligand binding site mutation search in PubMed: SENP1 | ||
UCL Cancer Institute: SENP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SENP1 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for SENP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for SENP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-138-5p | MIMAT0000430 | 0.013 | -0.28 | 78 |
ACC | hsa-miR-138-5p | MIMAT0000430 | 0.013 | -0.28 | 78 |
UCS | hsa-miR-181d-5p | MIMAT0002821 | 0.026 | -0.3 | 56 |
Top |
TissGeneMut for SENP1 |
TissGeneSNV for SENP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R166* | UCEC | 2 |
p.E121K | BLCA | 1 |
p.P156S | SKCM | 1 |
p.R618T | LUSC | 1 |
p.T288A | HNSC | 1 |
p.S84P | LIHC | 1 |
p.A492V | KIRC | 1 |
p.V526A | STAD | 1 |
p.R177X | STAD | 1 |
p.P30L | LIHC | 1 |
p.E469K | CESC | 1 |
p.R123Q | SARC | 1 |
p.P156L | SKCM | 1 |
p.I431L | HNSC | 1 |
p.V318A | UCEC | 1 |
p.P67L | SKCM | 1 |
p.T16A | LIHC | 1 |
p.R454H | STAD | 1 |
p.D415H | LUSC | 1 |
p.Q404* | HNSC | 1 |
p.R123Q | BLCA | 1 |
p.T59A | UCEC | 1 |
p.H411Y | SKCM | 1 |
p.E578A | STAD | 1 |
p.D43H | ESCA | 1 |
p.M137I | LUAD | 1 |
p.P158S | SKCM | 1 |
p.P103S | SKCM | 1 |
p.S78L | UCEC | 1 |
p.R391C | SKCM | 1 |
p.P107L | SKCM | 1 |
p.A182V | UCEC | 1 |
p.I21N | KIRC | 1 |
p.H291Y | SKCM | 1 |
p.D11H | ESCA | 1 |
p.S127_splice | LUSC | 1 |
p.C603G | SKCM | 1 |
p.K485N | STAD | 1 |
p.L41I | ESCA | 1 |
p.R358H | SARC | 1 |
p.A113P | LUAD | 1 |
p.S130* | HNSC | 1 |
p.G45A | BLCA | 1 |
p.R481* | UCEC | 1 |
p.R436C | SKCM | 1 |
p.A94T | BRCA | 1 |
p.H140Y | SKCM | 1 |
p.R177* | STAD | 1 |
p.R221* | BLCA | 1 |
p.E184K | CESC | 1 |
p.R436H | READ | 1 |
p.K119E | LUAD | 1 |
p.R481X | THYM | 1 |
p.P76S | SKCM | 1 |
p.Q205R | ESCA | 1 |
p.L168P | LIHC | 1 |
p.E190K | LUAD | 1 |
p.A134V | STAD | 1 |
p.R177* | PRAD | 1 |
Top |
TissGeneCNV for SENP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for SENP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CK902687 | SENP1-MSRB3 | chr12:48499840 | chr12:65702308 | |
Chimerdb3.0 | ChiTaRs | NA | CD367536 | SENP1-ILF3 | chr12:48479516 | chr19:10787699 | |
Chimerdb3.0 | ChiTaRs | NA | BU681052 | SENP1-SENP1 | chr12:48488030 | chr12:48482479 | |
Chimerdb3.0 | ChiTaRs | NA | BU785369 | SENP1-MSRB3 | chr12:48499900 | chr12:65702308 | |
Chimerdb3.0 | ChiTaRs | NA | BI462236 | SENP1-SPDYA | chr12:48499845 | chr2:29041912 |
Top |
TissGeneNet for SENP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for SENP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for SENP1 |
TissGeneDrug for SENP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for SENP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
umls:C0600139 | Prostate carcinoma | 5 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0274294 | Chronic mountain sickness | 2 | BeFree |
umls:C0282612 | Prostatic Intraepithelial Neoplasias | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 1 | LHGDN |
umls:C0023418 | leukemia | 1 | LHGDN |
umls:C0023524 | Leukoencephalopathy, Progressive Multifocal | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0878544 | Cardiomyopathies | 1 | BeFree |
umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
umls:C1168327 | High-Grade Prostatic Intraepithelial Neoplasia | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1853195 | Prostate Cancer, Hereditary, 7 | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |