TissGeneSummary for HCFC2 |
Gene summary |
Basic gene information | Gene symbol | HCFC2 |
Gene name | host cell factor C2 | |
Synonyms | HCF-2|HCF2 | |
Cytomap | UCSC genome browser: 12q23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_013320.2, | |
Description | C2 factorhost cell factor 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607926 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111727 | ||
HPRD : 06393 | ||
Vega : OTTHUMG00000170175 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HCFC2 | |
BioGPS: 29915 | ||
Pathway | NCI Pathway Interaction Database: HCFC2 | |
KEGG: HCFC2 | ||
REACTOME: HCFC2 | ||
Pathway Commons: HCFC2 | ||
Context | iHOP: HCFC2 | |
ligand binding site mutation search in PubMed: HCFC2 | ||
UCL Cancer Institute: HCFC2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HCFC2 | ||
Description by TissGene annotations | TissgsLTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HCFC2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.233888978 | 0.808120397 | -1.042009375 | 1.43E-07 | 3.61E-06 |
COAD | -0.884001237 | 0.211491071 | -1.095492308 | 1.76E-08 | 1.47E-07 |
ESCA | 0.110750511 | 1.132505057 | -1.021754545 | 5.42E-05 | 0.002114751 |
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TissGene-miRNA for HCFC2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUSC | hsa-let-7c-5p | MIMAT0000064 | 0.0036 | -0.26 | 128 |
THYM | hsa-miR-520e | MIMAT0002825 | 0.012 | -0.28 | 122 |
UCS | hsa-miR-381-3p | MIMAT0000736 | 0.035 | -0.28 | 56 |
UCS | hsa-miR-495-3p | MIMAT0002817 | 0.035 | -0.28 | 56 |
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TissGeneMut for HCFC2 |
TissGeneSNV for HCFC2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R107H | BRCA | 1 |
p.W232C | UCEC | 1 |
p.P675S | SARC | 1 |
p.V91A | UCEC | 1 |
p.S303Y | LUSC | 1 |
p.T369A | LIHC | 1 |
p.A322V | THYM | 1 |
p.T56M | COAD | 1 |
p.P703L | LUAD | 1 |
p.R596* | UCEC | 1 |
p.A589S | SARC | 1 |
p.E92Q | BLCA | 1 |
p.V86L | UCEC | 1 |
p.P584L | SKCM | 1 |
p.E167* | LUAD | 1 |
p.S428_splice | LUSC | 1 |
p.R596* | UCS | 1 |
p.P587S | SKCM | 1 |
p.K592X | ESCA | 1 |
p.L502R | LUSC | 1 |
p.E558* | UCEC | 1 |
p.K485R | LUSC | 1 |
p.G129* | SKCM | 1 |
p.Y209H | STAD | 1 |
p.D151H | BRCA | 1 |
p.P187H | UCEC | 1 |
p.G71D | ESCA | 1 |
p.A73S | THYM | 1 |
p.R127Q | UCEC | 1 |
p.E150K | READ | 1 |
p.T458M | OV | 1 |
p.G71V | BLCA | 1 |
p.H276Y | BLCA | 1 |
p.L610F | HNSC | 1 |
p.K592* | ESCA | 1 |
p.E445* | LUSC | 1 |
p.L390F | CESC | 1 |
p.T739I | HNSC | 1 |
p.R780W | READ | 1 |
p.R596X | UCS | 1 |
p.R326Q | COAD | 1 |
p.P466S | SKCM | 1 |
p.E582D | ESCA | 1 |
p.I624F | LUAD | 1 |
p.R780W | SKCM | 1 |
p.P681H | ESCA | 1 |
p.E691K | LUAD | 1 |
p.Q389K | LUAD | 1 |
p.E102K | CESC | 1 |
p.R218H | STAD | 1 |
p.G662R | BRCA | 1 |
p.K639T | COAD | 1 |
p.R245Q | ESCA | 1 |
p.G44S | SKCM | 1 |
p.S131I | UCEC | 1 |
p.K138N | PAAD | 1 |
p.Y93C | SKCM | 1 |
p.D415N | LUAD | 1 |
p.E582K | STAD | 1 |
p.V64L | BRCA | 1 |
p.R245* | CESC | 1 |
p.S625* | HNSC | 1 |
p.F142C | LUAD | 1 |
p.W9* | LUAD | 1 |
p.E191G | UCEC | 1 |
p.C72G | SKCM | 1 |
p.H193Y | SKCM | 1 |
p.A22T | COAD | 1 |
p.S285L | SKCM | 1 |
p.H475Y | PRAD | 1 |
p.S274L | SKCM | 1 |
p.M230I | PRAD | 1 |
p.L643I | UCEC | 1 |
p.W330C | LUSC | 1 |
p.N786S | LUAD | 1 |
p.P242S | READ | 1 |
p.A28S | UCEC | 1 |
p.K267N | THYM | 1 |
p.G89E | BRCA | 1 |
p.W781C | ESCA | 1 |
p.N724I | LUSC | 1 |
p.R27P | LUAD | 1 |
p.P584L | UCS | 1 |
p.G324S | STAD | 1 |
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TissGeneCNV for HCFC2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HCFC2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA625768 | MYOT-HCFC2 | chr5:137087660 | chr12:104495890 | |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7416-01A | CHST11-HCFC2 | In-frame | Chr12:104851292 | Chr12:104459945 |
TCGAfusionPortal | PRADA | LGG | TCGA-HT-7611-01A | HCFC2-ANKS1B | Out-of-frame | Chr12:104492258 | Chr12:99640642 |
TCGAfusionPortal | PRADA | LUSC | TCGA-43-2578-01A | TXNRD1-HCFC2 | Out-of-frame | Chr12:104682818 | Chr12:104474524 |
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TissGeneNet for HCFC2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HCFC2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HCFC2 |
TissGeneDrug for HCFC2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HCFC2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |