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| TissGeneSummary for GYPA |
 Gene summary |
| Basic gene information | Gene symbol | GYPA |
| Gene name | glycophorin A (MNS blood group) | |
| Synonyms | CD235a|GPA|GPErik|GPSAT|HGpMiV|HGpMiXI|HGpSta(C)|MN|MNS|PAS-2 | |
| Cytomap | UCSC genome browser: 4q31.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002099.6, | |
| Description | MN sialoglycoproteinMi.V glycoprotein (24 AA)erythroid-lineage-specific membrane sialoglycoproteinglycophorin A (MN blood group)glycophorin A, GPAglycophorin Erikglycophorin MiIglycophorin MiVglycophorin SATglycophorin Sta type Cglycophorin-Are | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 111300 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170180 | ||
| HPRD : 07508 | ||
| Vega : OTTHUMG00000161403 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GYPA | |
| BioGPS: 2993 | ||
| Pathway | NCI Pathway Interaction Database: GYPA | |
| KEGG: GYPA | ||
| REACTOME: GYPA | ||
| Pathway Commons: GYPA | ||
| Context | iHOP: GYPA | |
| ligand binding site mutation search in PubMed: GYPA | ||
| UCL Cancer Institute: GYPA | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrow | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAML | |
| Reference showing the relevant tissue of GYPA | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GYPA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.310616794 | 2.504727206 | -2.815344 | 2.36E-06 | 8.31E-06 |
| KIRP | 0.911629331 | 3.444041831 | -2.5324125 | 3.30E-06 | 1.50E-05 |
| KIRC | 1.845844261 | 2.91487065 | -1.069026389 | 0.0018 | 0.003309106 |
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| TissGene-miRNA for GYPA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GYPA |
| TissGeneSNV for GYPA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R115C | SKCM | 2 |
| p.H85L | LIHC | 2 |
| p.G78E | SKCM | 2 |
| p.Y53H | LUAD | 1 |
| p.A26V | COAD | 1 |
| p.G98E | SKCM | 1 |
| p.R80S | LUAD | 1 |
| p.E141K | BLCA | 1 |
| p.I106N | STAD | 1 |
| p.D134V | LIHC | 1 |
| p.P145Q | SKCM | 1 |
| p.I99L | STAD | 1 |
| p.P129S | SKCM | 1 |
| p.E89Q | BLCA | 1 |
| p.S111F | SKCM | 1 |
| p.L128V | BLCA | 1 |
| p.E141K | HNSC | 1 |
| p.E141* | BLCA | 1 |
| p.A54E | COAD | 1 |
| p.E61K | SKCM | 1 |
| p.R115C | GBM | 1 |
| p.P72S | SKCM | 1 |
| p.A84D | ESCA | 1 |
| p.T47M | HNSC | 1 |
| p.E61X | COAD | 1 |
| p.T147K | HNSC | 1 |
| p.E89K | SKCM | 1 |
| p.T93P | STAD | 1 |
| p.P131H | HNSC | 1 |
| p.D149N | UCEC | 1 |
| p.R116Q | READ | 1 |
| p.H85L | LUAD | 1 |
| p.E143K | SKCM | 1 |
| p.A84V | HNSC | 1 |
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| TissGeneCNV for GYPA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GYPA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-77-7142-11A | SAV1-GYPA | In-Frame | chr14:51131896 | chr4:145041741 |
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| TissGeneNet for GYPA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for GYPA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GYPA |
| TissGeneDrug for GYPA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GYPA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024530 | Malaria | 5 | BeFree,CTD_human,GAD |
| umls:C0015625 | Fanconi Anemia | 3 | BeFree |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,GAD |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 3 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 3 | GAD |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 3 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | BeFree |
| umls:C0004096 | Asthma | 2 | GAD |
| umls:C0004135 | Ataxia Telangiectasia | 2 | BeFree |
| umls:C0010346 | Crohn Disease | 2 | GAD |
| umls:C0037889 | Hereditary spherocytosis | 2 | BeFree |
| umls:C0042384 | Vasculitis | 2 | BeFree |
| umls:C0343192 | Microscopic Polyangiitis | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C2674218 | SPHEROCYTOSIS, TYPE 1 (disorder) | 2 | BeFree |
| umls:C0002874 | Aplastic Anemia | 1 | BeFree |
| umls:C0002875 | Cooley's anemia | 1 | BeFree |
| umls:C0006277 | Bronchitis | 1 | BeFree |
| umls:C0008677 | Bronchitis, Chronic | 1 | BeFree |
| umls:C0008728 | Churg-Strauss Syndrome | 1 | BeFree |
| umls:C0009207 | Cockayne Syndrome | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0014761 | Erythroblastosis, Fetal | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0019045 | Hemoglobinopathies | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0024591 | Malignant hyperpyrexia due to anesthesia | 1 | BeFree |
| umls:C0024790 | Paroxysmal nocturnal hemoglobinuria | 1 | BeFree |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0032461 | Polycythemia | 1 | LHGDN |
| umls:C0032463 | Polycythemia Vera | 1 | BeFree |
| umls:C0034152 | Henoch-Schoenlein Purpura | 1 | GAD |
| umls:C0037286 | Skin Neoplasms | 1 | BeFree,CTD_human |
| umls:C0043119 | Werner Syndrome | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0263361 | Psoriasis vulgaris | 1 | GAD |
| umls:C0265962 | Ichthyosis linearis circumflexa | 1 | BeFree |
| umls:C0268225 | Aspartylglucosaminuria | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0349653 | Congenital disorder of glycosylation type 1A | 1 | BeFree |
| umls:C0392707 | Atopy | 1 | GAD |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1327915 | Congenital amegakaryocytic thrombocytopenia | 1 | BeFree |
| umls:C1704380 | Distal Renal Tubular Acidosis | 1 | BeFree |
| umls:C1856689 | FRIEDREICH ATAXIA 1 | 1 | BeFree |
| umls:C1862839 | Anterior segment mesenchymal dysgenesis | 1 | BeFree |
| umls:C2678503 | AXENFELD-RIEGER SYNDROME, TYPE 3 | 1 | BeFree |
| umls:C2717865 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 1 | BeFree |
| umls:C2939465 | Deficiency of glucose-6-phosphate dehydrogenase | 1 | BeFree |
| umls:C3550904 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Is | 1 | BeFree |
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