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TissGeneSummary for RPA4 |
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Basic gene information | Gene symbol | RPA4 |
Gene name | replication protein A4, 30kDa | |
Synonyms | HSU24186 | |
Cytomap | UCSC genome browser: Xq21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_013347.4, | |
Description | RF-A protein 4RP-A p30replication factor A protein 4replication protein A 30 kDa subunitreplication protein A complex 34 kd subunit homolog Rpa4replication protein A4, 34kDa | |
Modification date | 20141207 | |
dbXrefs | MIM : 300767 | |
HGNC : HGNC | ||
Ensembl : ENSG00000204086 | ||
HPRD : 06591 | ||
Vega : OTTHUMG00000021987 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RPA4 | |
BioGPS: 29935 | ||
Pathway | NCI Pathway Interaction Database: RPA4 | |
KEGG: RPA4 | ||
REACTOME: RPA4 | ||
Pathway Commons: RPA4 | ||
Context | iHOP: RPA4 | |
ligand binding site mutation search in PubMed: RPA4 | ||
UCL Cancer Institute: RPA4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RPA4 | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0000077 | DNA damage checkpoint | 19942684 | GO:0006289 | nucleotide-excision repair | 19996105 | GO:0033260 | nuclear DNA replication | 19116208 | GO:0000077 | DNA damage checkpoint | 19942684 | GO:0006289 | nucleotide-excision repair | 19996105 | GO:0033260 | nuclear DNA replication | 19116208 |
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TissGeneExp for RPA4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for RPA4 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RPA4 |
TissGeneSNV for RPA4 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E141D | UCEC | 2 |
p.V63M | LUAD | 1 |
p.I145T | LUSC | 1 |
p.K170X | KIRC | 1 |
p.A225S | LUAD | 1 |
p.L54H | SKCM | 1 |
p.L55F | CESC | 1 |
p.V232I | UCEC | 1 |
p.I145V | GBM | 1 |
p.V244I | PRAD | 1 |
p.K170E | ACC | 1 |
p.D203E | SKCM | 1 |
p.G246D | STAD | 1 |
p.G109D | KIRP | 1 |
p.S57F | CESC | 1 |
p.E84D | LUAD | 1 |
p.V156M | LUAD | 1 |
p.R105X | ESCA | 1 |
p.R173H | STAD | 1 |
p.H157Q | HNSC | 1 |
p.S13C | ESCA | 1 |
p.V116A | LUAD | 1 |
p.Y249C | ESCA | 1 |
p.E216K | SKCM | 1 |
p.P250S | SKCM | 1 |
p.S185* | LUSC | 1 |
p.R207H | STAD | 1 |
p.V244A | STAD | 1 |
p.M167I | LUAD | 1 |
p.N88Y | BLCA | 1 |
p.V59L | OV | 1 |
p.R105* | ESCA | 1 |
p.T161M | GBM | 1 |
p.V46I | UCS | 1 |
p.H214Y | CESC | 1 |
p.G21D | COAD | 1 |
p.R38I | READ | 1 |
p.D61N | COAD | 1 |
p.Q226E | LUAD | 1 |
p.R224W | STAD | 1 |
p.R42Q | UCEC | 1 |
p.R173C | UCEC | 1 |
p.A83V | OV | 1 |
p.K258N | SARC | 1 |
p.V232I | PRAD | 1 |
p.H165L | LUAD | 1 |
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TissGeneCNV for RPA4 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RPA4 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RPA4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RPA4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RPA4 |
TissGeneDrug for RPA4 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RPA4 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |