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| TissGeneSummary for GYPB |
 Gene summary |
| Basic gene information | Gene symbol | GYPB |
| Gene name | glycophorin B (MNS blood group) | |
| Synonyms | CD235b|GPB|GPB.NY|GYPHe.NY|GpMiIII|HGpMiIII|HGpMiVI|HGpMiX|MNS|PAS-3|SS | |
| Cytomap | UCSC genome browser: 4q31.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002100.4, | |
| Description | SS-active sialoglycoproteinSs blood groupglycophorin HeP2glycophorin MiIIIglycophorin MiVIglycophorin MiXglycophorin-Bsialoglycoprotein delta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 111740 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000250361 | ||
| HPRD : 00201 | ||
| Vega : OTTHUMG00000161404 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GYPB | |
| BioGPS: 2994 | ||
| Pathway | NCI Pathway Interaction Database: GYPB | |
| KEGG: GYPB | ||
| REACTOME: GYPB | ||
| Pathway Commons: GYPB | ||
| Context | iHOP: GYPB | |
| ligand binding site mutation search in PubMed: GYPB | ||
| UCL Cancer Institute: GYPB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrow | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAML | |
| Reference showing the relevant tissue of GYPB | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GYPB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for GYPB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GYPB |
| TissGeneSNV for GYPB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R54C | SKCM | 4 |
| p.R86C | SKCM | 3 |
| p.T48S | LIHC | 1 |
| p.R86H | COAD | 1 |
| p.V25M | SKCM | 1 |
| p.L20S | ESCA | 1 |
| p.Q50E | HNSC | 1 |
| p.R50W | UCEC | 1 |
| p.E63* | UCEC | 1 |
| p.S16R | LUAD | 1 |
| p.I74N | SKCM | 1 |
| p.I74N | STAD | 1 |
| p.E13A | OV | 1 |
| p.V52A | COAD | 1 |
| p.E24K | BRCA | 1 |
| p.Q50K | HNSC | 1 |
| p.R87Q | PRAD | 1 |
| p.L79H | LUAD | 1 |
| p.S41* | BRCA | 1 |
| p.S34L | BLCA | 1 |
| p.R86H | UCEC | 1 |
| p.T48M | COAD | 1 |
| p.A26T | SKCM | 1 |
| p.I67L | STAD | 1 |
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| TissGeneCNV for GYPB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GYPB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | THYM | TCGA-4X-A9FD-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-K1-A6RT-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-K1-A6RU-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-MO-A47P-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-HT-8011-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-DU-6407-02B | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A2FV-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1EN-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1F6-11B | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AC-A2QH-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-EY-A2ON-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | UVM | TCGA-YZ-A984-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | UVM | TCGA-V3-A9ZY-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-38-4627-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-2668-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-5645-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-6144-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-6146-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-6148-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-49-6745-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-49-6761-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-50-5930-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-50-5932-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-50-5935-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-50-5939-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-55-6970-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-55-7227-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-55-8299-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-86-7954-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-83-5908-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-86-A4P8-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LAML | TCGA-AB-2941-03A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | DLBC | TCGA-FA-A6HO-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-43-A56U-01A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-68-7757-01B | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-43-7658-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-51-4079-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-77-7337-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-77-7142-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-22-5483-11A | SAV1-GYPB | In-Frame | chr14:51131896 | chr4:144922436 |
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| TissGeneNet for GYPB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| COAD (tumor) | COAD (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| KICH (tumor) | KICH (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| STAD (tumor) | STAD (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| THCA (tumor) | THCA (normal) |
| GYPB, RHAG (tumor) | GYPB, RHAG (normal) |
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| TissGeneProg for GYPB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GYPB |
| TissGeneDrug for GYPB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GYPB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | BeFree |
| umls:C0020538 | Hypertensive disease | 2 | BeFree |
| umls:C0024530 | Malaria | 2 | BeFree |
| umls:C0006277 | Bronchitis | 1 | BeFree |
| umls:C0008677 | Bronchitis, Chronic | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0019045 | Hemoglobinopathies | 1 | BeFree |
| umls:C0024591 | Malignant hyperpyrexia due to anesthesia | 1 | BeFree |
| umls:C0037889 | Hereditary spherocytosis | 1 | BeFree |
| umls:C0086981 | Sicca Syndrome | 1 | BeFree |
| umls:C0265962 | Ichthyosis linearis circumflexa | 1 | BeFree |
| umls:C0268225 | Aspartylglucosaminuria | 1 | BeFree |
| umls:C1862839 | Anterior segment mesenchymal dysgenesis | 1 | BeFree |
| umls:C2674218 | SPHEROCYTOSIS, TYPE 1 (disorder) | 1 | BeFree |
| umls:C2678503 | AXENFELD-RIEGER SYNDROME, TYPE 3 | 1 | BeFree |
| umls:C2939465 | Deficiency of glucose-6-phosphate dehydrogenase | 1 | BeFree |
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