TissGeneSummary for A1CF |
Gene summary |
Basic gene information | Gene symbol | A1CF |
Gene name | APOBEC1 complementation factor | |
Synonyms | ACF|ACF64|ACF65|APOBEC1CF|ASP | |
Cytomap | UCSC genome browser: 10q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_001198818.1, NM_001198819.1,NM_001198820.1,NM_014576.3,NM_138932.2, NM_138933.2, | |
Description | APOBEC-1 stimulating proteinapo-B RNA editing proteinapobec-1 complementation factor (ACF) (ASP) | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000148584 | ||
HPRD : 10627 | ||
Vega : OTTHUMG00000018240 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_A1CF | |
BioGPS: 29974 | ||
Pathway | NCI Pathway Interaction Database: A1CF | |
KEGG: A1CF | ||
REACTOME: A1CF | ||
Pathway Commons: A1CF | ||
Context | iHOP: A1CF | |
ligand binding site mutation search in PubMed: A1CF | ||
UCL Cancer Institute: A1CF | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSTAD | |
Reference showing the relevant tissue of A1CF | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0050821 | protein stabilization | 12881431 | GO:0050821 | protein stabilization | 12881431 |
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TissGeneExp for A1CF |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 5.549331236 | 6.741365851 | -1.192034615 | 1.37E-05 | 6.09E-05 |
KICH | -1.423799226 | 3.339336774 | -4.763136 | 9.61E-10 | 6.02E-09 |
KIRC | 5.237026107 | 4.230633052 | 1.006393056 | 0.0214 | 0.034084861 |
KIRP | 2.338811524 | 4.965136524 | -2.626325 | 0.000126 | 0.000418507 |
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TissGene-miRNA for A1CF |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for A1CF |
TissGeneSNV for A1CF |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E34K | SKCM | 5 |
p.P57S | SKCM | 2 |
p.Q33* | SKCM | 2 |
p.L126F | SKCM | 2 |
p.D329N | SKCM | 2 |
p.G403E | SKCM | 2 |
p.G318R | SKCM | 2 |
p.E50K | SKCM | 2 |
p.G402E | SKCM | 2 |
p.G35V | HNSC | 1 |
p.T37P | READ | 1 |
p.R58* | SKCM | 1 |
p.G10R | SKCM | 1 |
p.E250D | GBM | 1 |
p.R587Q | LUSC | 1 |
p.G420R | COAD | 1 |
p.G28E | SKCM | 1 |
p.P426L | SKCM | 1 |
p.P370S | SKCM | 1 |
p.K110N | UCEC | 1 |
p.P6S | SKCM | 1 |
p.G141W | STAD | 1 |
p.A395T | SKCM | 1 |
p.A565E | LGG | 1 |
p.E187K | BLCA | 1 |
p.M85K | LUAD | 1 |
p.G201E | SKCM | 1 |
p.G26R | SKCM | 1 |
p.G208* | STAD | 1 |
p.K24N | SKCM | 1 |
p.R392C | SKCM | 1 |
p.E217Q | BLCA | 1 |
p.Q442* | SKCM | 1 |
p.A165T | PRAD | 1 |
p.Y91H | CHOL | 1 |
p.G407E | BLCA | 1 |
p.F479L | UCEC | 1 |
p.E253Q | LUAD | 1 |
p.E270K | SKCM | 1 |
p.G203D | SKCM | 1 |
p.A508G | LUAD | 1 |
p.Y397* | HNSC | 1 |
p.E120K | BLCA | 1 |
p.A112G | CESC | 1 |
p.G28A | BLCA | 1 |
p.K554E | HNSC | 1 |
p.S132N | PRAD | 1 |
p.H360R | LIHC | 1 |
p.P377S | SKCM | 1 |
p.R21H | HNSC | 1 |
p.F587L | LUAD | 1 |
p.A19V | SKCM | 1 |
p.R26H | OV | 1 |
p.E224D | SKCM | 1 |
p.C9Y | COAD | 1 |
p.R476T | HNSC | 1 |
p.P345S | SKCM | 1 |
p.A57V | THYM | 1 |
p.G421E | HNSC | 1 |
p.E154K | SKCM | 1 |
p.M384I | SKCM | 1 |
p.G90E | LGG | 1 |
p.R125H | GBM | 1 |
p.Q33X | SKCM | 1 |
p.K9N | SKCM | 1 |
p.Y76H | CHOL | 1 |
p.T18A | STAD | 1 |
p.A188V | LUAD | 1 |
p.E77* | LUAD | 1 |
p.M78K | LUAD | 1 |
p.E17K | SKCM | 1 |
p.F68V | STAD | 1 |
p.R469T | HNSC | 1 |
p.E508K | COAD | 1 |
p.D336N | SKCM | 1 |
p.P444S | LIHC | 1 |
p.L119F | SKCM | 1 |
p.Y404* | HNSC | 1 |
p.D83N | SKCM | 1 |
p.A195V | LUAD | 1 |
p.A188V | PAAD | 1 |
p.A188V | HNSC | 1 |
p.E116D | LIHC | 1 |
p.K89X | KIRC | 1 |
p.M377I | SKCM | 1 |
p.R183Q | PAAD | 1 |
p.R259* | SKCM | 1 |
p.R179* | UCEC | 1 |
p.G366X | LGG | 1 |
p.P429H | PRAD | 1 |
p.N104T | LUAD | 1 |
p.E71K | SKCM | 1 |
p.H375R | LIHC | 1 |
p.S323F | SKCM | 1 |
p.Y349X | THYM | 1 |
p.S125N | PRAD | 1 |
p.R198Q | PAAD | 1 |
p.S330F | SKCM | 1 |
p.V184L | LUAD | 1 |
p.D523N | SKCM | 1 |
p.D424E | BRCA | 1 |
p.E57K | SKCM | 1 |
p.E260Q | LUAD | 1 |
p.A195V | PAAD | 1 |
p.R47K | SKCM | 1 |
p.E113K | SKCM | 1 |
p.A193S | LUSC | 1 |
p.E64K | SKCM | 1 |
p.Q333H | SKCM | 1 |
p.P547L | KIRC | 1 |
p.T565N | GBM | 1 |
p.A380V | STAD | 1 |
p.A188V | PRAD | 1 |
p.L31F | LIHC | 1 |
p.Q485R | STAD | 1 |
p.E509K | SKCM | 1 |
p.E40K | SKCM | 1 |
p.R364K | SKCM | 1 |
p.S249P | LIHC | 1 |
p.G408R | PRAD | 1 |
p.Q326H | SKCM | 1 |
p.A203V | PRAD | 1 |
p.R266X | SKCM | 1 |
p.V222L | OV | 1 |
p.A269V | UCEC | 1 |
p.Q477R | STAD | 1 |
p.R580Q | LUAD | 1 |
p.P428S | SKCM | 1 |
p.R189M | LUAD | 1 |
p.I254F | LUSC | 1 |
p.A203V | PAAD | 1 |
p.G407R | PRAD | 1 |
p.L233I | UCEC | 1 |
p.E25K | SKCM | 1 |
p.K224R | PRAD | 1 |
p.A396T | SKCM | 1 |
p.A544T | THYM | 1 |
p.A195V | BRCA | 1 |
p.G7S | SKCM | 1 |
p.G420E | SKCM | 1 |
p.F594L | LUAD | 1 |
p.P436S | LUSC | 1 |
p.A278T | SKCM | 1 |
p.G216X | STAD | 1 |
p.Q441X | SKCM | 1 |
p.G149W | STAD | 1 |
p.E217D | SKCM | 1 |
p.V177L | LUAD | 1 |
p.G11E | SKCM | 1 |
p.E64* | LUAD | 1 |
p.E85G | LIHC | 1 |
p.A285T | SKCM | 1 |
p.G421E | SKCM | 1 |
p.E245D | CESC | 1 |
p.G325R | SKCM | 1 |
p.E148K | HNSC | 1 |
p.E120K | SKCM | 1 |
p.P64S | SKCM | 1 |
p.P562L | KIRC | 1 |
p.A349V | STAD | 1 |
p.G22S | SKCM | 1 |
p.P338S | SKCM | 1 |
p.M149I | SKCM | 1 |
p.E2K | SKCM | 1 |
p.G11R | SKCM | 1 |
p.G336R | SKCM | 1 |
p.P429T | SARC | 1 |
p.R373I | KIRC | 1 |
p.A365V | STAD | 1 |
p.P429S | SKCM | 1 |
p.R307* | LGG | 1 |
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TissGeneCNV for A1CF |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for A1CF |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BC022263 | A1CF-ANKDD1A | chr10:52623842 | chr15:65245027 | |
Chimerdb3.0 | ChiTaRs | NA | AW300983 | A1CF-A1CF | chr10:52566513 | chr10:52566487 |
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TissGeneNet for A1CF |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for A1CF |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for A1CF |
TissGeneDrug for A1CF |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for A1CF |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0028754 | Obesity | 5 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 4 | BeFree |
umls:C1527249 | Colorectal Cancer | 4 | BeFree |
umls:C0001430 | Adenoma | 3 | BeFree |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 3 | BeFree |
umls:C0019693 | HIV Infections | 3 | BeFree |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 3 | BeFree |
umls:C3714757 | Juvenile rheumatoid arthritis | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0016037 | Fibrodysplasia Ossificans Progressiva | 2 | BeFree |
umls:C0233523 | Antisocial behavior | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0008350 | Cholelithiasis | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
umls:C0026946 | Mycoses | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0155877 | Allergic asthma | 1 | BeFree |
umls:C0751651 | Mitochondrial Diseases | 1 | BeFree |
umls:C0947622 | Cholecystolithiasis | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
umls:C1535939 | Pneumocystis jiroveci pneumonia | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C3532239 | Mitochondrial cardiomyopathy | 1 | BeFree |