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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HABP2
check button Gene summary
Basic gene informationGene symbolHABP2
Gene namehyaluronan binding protein 2
SynonymsFSAP|HABP|HGFAL|PHBP
CytomapUCSC genome browser: 10q25.3
Type of geneprotein-coding
RefGenesNM_001177660.1,
NM_004132.3,
Descriptionfactor VII activating proteinfactor VII-activating proteasefactor seven-activating proteasehepatocyte growth factor activator-like proteinhyaluronan-binding protein 2hyaluronic acid binding protein 2plasma hyaluronan binding proteinplasma hyalurona
Modification date20141207
dbXrefs MIM : 603924
HGNC : HGNC
Ensembl : ENSG00000148702
HPRD : 04890
Vega : OTTHUMG00000019073
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HABP2
BioGPS: 3026
PathwayNCI Pathway Interaction Database: HABP2
KEGG: HABP2
REACTOME: HABP2
Pathway Commons: HABP2
ContextiHOP: HABP2
ligand binding site mutation search in PubMed: HABP2
UCL Cancer Institute: HABP2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of HABP2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for HABP2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-1.1371412881.165521457-2.3026627452.21E-075.98E-07
LIHC7.2948842819.415940281-2.1210564.48E-072.63E-06
KICH-1.8098997192.018396281-3.8282962.44E-071.03E-06
LUAD2.0561751090.8988406261.1573344830.01120.019811987
COAD-2.435146642-4.4195966421.984450.001480.00408398


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TissGene-miRNA for HABP2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for HABP2
TissGeneSNV for HABP2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G81ESKCM2
p.P442SSKCM2
p.P132SSKCM2
p.P416SSKCM2
p.E557KSKCM1
p.C451SSKCM1
p.S84LSKCM1
p.E282ASKCM1
p.S450FBLCA1
p.P288TGBM1
p.P284SKIRC1
p.M232ILUAD1
p.P126SSKCM1
p.P39SSKCM1
p.Q212*OV1
p.G173ESKCM1
p.G519RLUAD1
p.G60RCOAD1
p.P65SSKCM1
p.P106SSKCM1
p.E47DUCEC1
p.S490RLUAD1
p.P79SSKCM1
p.E188KSKCM1
p.S428FLUSC1
p.K169NUCEC1
p.G197DSTAD1
p.P65TLUAD1
p.G559VSARC1
p.K371QREAD1
p.Q181HLUAD1
p.M206IUCEC1
p.T541ISKCM1
p.R155KLIHC1
p.E305GSTAD1
p.T38IUCEC1
p.A214VSTAD1
p.G159ESKCM1
p.G317DHNSC1
p.G158ESKCM1
p.E282VSKCM1
p.P291SUCEC1
p.H386YSKCM1
p.G75ESKCM1
p.E264KSKCM1
p.C176GOV1
p.R208KSKCM1
p.R182KSKCM1
p.G94ESKCM1
p.F186LUCS1
p.Q279EPCPG1
p.C477SSKCM1
p.E290KSKCM1
p.C165SBLCA1
p.K107NSKCM1
p.Q481PPAAD1
p.E253KUCEC1
p.K418QSTAD1
p.D280VSTAD1
p.E446KBLCA1
p.T515ISKCM1
p.E308ASKCM1
p.R462HLUSC1
p.G239EHNSC1
p.N50TSTAD1
p.K254QSTAD1
p.K381NUCEC1
p.P76SSKCM1
p.G184ESKCM1
p.G460RSKCM1
p.A552TSKCM1
p.C108SSKCM1
p.P158SSKCM1
p.Q388RLIHC1
p.R122WHNSC1
p.S334LCESC1
p.S277LBRCA1
p.R155SLIHC1
p.P152SSKCM1
p.G81EUCS1
p.C88*LUAD1
p.P35QKIRC1
p.S171LSKCM1
p.P81LSKCM1
p.E308VSKCM1
p.P102SSKCM1
p.S399GUCEC1
p.V184IREAD1
p.L100ICOAD1


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TissGeneCNV for HABP2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for HABP2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for HABP2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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COAD (tumor)COAD (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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HNSC (tumor)HNSC (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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KICH (tumor)KICH (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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KIRC (tumor)KIRC (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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KIRP (tumor)KIRP (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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LIHC (tumor)LIHC (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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LUAD (tumor)LUAD (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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LUSC (tumor)LUSC (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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PRAD (tumor)PRAD (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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STAD (tumor)STAD (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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THCA (tumor)THCA (normal)
HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (tumor)HABP2, HNF4A, ONECUT1, COL4A3, HNF1A, COL4A1, COL4A5, KNG1, COL4A6, COL4A2, COL4A4 (normal)
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TissGeneProg for HABP2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for HABP2
TissGeneDrug for HABP2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB08818Hyaluronic acidBinderSmall moleculeApproved|Vet_approved


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TissGeneDisease for HABP2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007282Carotid Stenosis3BeFree
umls:C0149871Deep Vein Thrombosis3BeFree
umls:C1861172Venous Thromboembolism3GAD,LHGDN
umls:C0003850Arteriosclerosis2BeFree
umls:C0004153Atherosclerosis2BeFree,LHGDN
umls:C0035222Respiratory Distress Syndrome, Adult2BeFree,LHGDN
umls:C0040038Thromboembolism2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0000786Spontaneous abortion1CTD_human
umls:C0001418Adenocarcinoma1BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0010054Coronary Arteriosclerosis1GAD
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0019087Hemorrhagic Disorders1GAD
umls:C0019196Hepatitis C1BeFree,GAD
umls:C0023890Liver Cirrhosis1BeFree,GAD
umls:C0036341Schizophrenia1BeFree
umls:C0038454Cerebrovascular accident1BeFree
umls:C0042487Venous Thrombosis1GAD
umls:C0333186Restenosis1BeFree
umls:C0340708Deep vein thrombosis of lower limb1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0398623Thrombophilia1BeFree,CTD_human
umls:C0549473Thyroid carcinoma1BeFree
umls:C0584960Factor V Leiden mutation1BeFree
umls:C0745744End Stage Liver Disease1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree
umls:C3501844Familial Nonmedullary Thyroid Cancer1BeFree