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| TissGeneSummary for HAL |
 Gene summary |
| Basic gene information | Gene symbol | HAL |
| Gene name | histidine ammonia-lyase | |
| Synonyms | HIS|HSTD | |
| Cytomap | UCSC genome browser: 12q22-q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001258333.1, NM_001258334.1,NM_002108.3, | |
| Description | histidase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609457 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000084110 | ||
| HPRD : 07187 | ||
| Vega : OTTHUMG00000170354 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HAL | |
| BioGPS: 3034 | ||
| Pathway | NCI Pathway Interaction Database: HAL | |
| KEGG: HAL | ||
| REACTOME: HAL | ||
| Pathway Commons: HAL | ||
| Context | iHOP: HAL | |
| ligand binding site mutation search in PubMed: HAL | ||
| UCL Cancer Institute: HAL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of HAL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HAL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.133709554 | 0.376780642 | -1.510490196 | 2.62E-06 | 6.30E-06 |
| LIHC | 5.326467976 | 7.985125976 | -2.658658 | 5.78E-06 | 2.59E-05 |
| HNSC | -0.450320908 | 1.61011165 | -2.060432558 | 0.000357 | 0.001380155 |
| LUAD | 1.433034665 | -0.033760162 | 1.466794828 | 4.22E-05 | 0.000112953 |
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| TissGene-miRNA for HAL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HAL |
| TissGeneSNV for HAL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R390C | SKCM | 2 |
| p.R356* | SKCM | 2 |
| p.P575A | HNSC | 1 |
| p.S47F | SKCM | 1 |
| p.C58F | HNSC | 1 |
| p.R69W | LGG | 1 |
| p.A253V | UCEC | 1 |
| p.R192H | UCEC | 1 |
| p.P204L | SKCM | 1 |
| p.R159W | COAD | 1 |
| p.R386C | SKCM | 1 |
| p.R148X | SKCM | 1 |
| p.G436V | LUAD | 1 |
| p.D393N | LUAD | 1 |
| p.A174V | UCEC | 1 |
| p.T502M | CESC | 1 |
| p.A20T | GBM | 1 |
| p.V48M | COAD | 1 |
| p.P652L | SKCM | 1 |
| p.R369W | SKCM | 1 |
| p.G446V | UCEC | 1 |
| p.P246S | SKCM | 1 |
| p.P652S | PRAD | 1 |
| p.S226F | PAAD | 1 |
| p.R328Q | STAD | 1 |
| p.L453V | BLCA | 1 |
| p.E601Q | OV | 1 |
| p.H52N | SARC | 1 |
| p.R469K | SKCM | 1 |
| p.S518F | SKCM | 1 |
| p.P367S | COAD | 1 |
| p.G100R | SKCM | 1 |
| p.R594C | SKCM | 1 |
| p.G41R | SKCM | 1 |
| p.E78K | SKCM | 1 |
| p.E30* | SKCM | 1 |
| p.S324T | BRCA | 1 |
| p.H376Y | SKCM | 1 |
| p.T309M | STAD | 1 |
| p.E550* | LUAD | 1 |
| p.E30K | BLCA | 1 |
| p.K415E | HNSC | 1 |
| p.H385Y | HNSC | 1 |
| p.W274C | ESCA | 1 |
| p.I166M | UCEC | 1 |
| p.V545A | STAD | 1 |
| p.R261K | SKCM | 1 |
| p.D87N | BRCA | 1 |
| p.S226F | SKCM | 1 |
| p.E565Q | BLCA | 1 |
| p.P516S | SKCM | 1 |
| p.R133C | LUAD | 1 |
| p.Y285C | UCEC | 1 |
| p.A433V | STAD | 1 |
| p.S648T | HNSC | 1 |
| p.R175T | ESCA | 1 |
| p.R369W | CHOL | 1 |
| p.S525R | SARC | 1 |
| p.R376C | COAD | 1 |
| p.R367W | SKCM | 1 |
| p.L129S | COAD | 1 |
| p.G249R | SKCM | 1 |
| p.G60D | GBM | 1 |
| p.P444L | SKCM | 1 |
| p.E264K | READ | 1 |
| p.R192L | LUSC | 1 |
| p.E39D | READ | 1 |
| p.V391I | LUSC | 1 |
| p.D593N | SKCM | 1 |
| p.P589L | SKCM | 1 |
| p.E115K | SKCM | 1 |
| p.K172T | UCEC | 1 |
| p.R161W | SKCM | 1 |
| p.R624K | BLCA | 1 |
| p.N76S | SKCM | 1 |
| p.R69W | PRAD | 1 |
| p.P429S | LGG | 1 |
| p.R114X | COAD | 1 |
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| TissGeneCNV for HAL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HAL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HAL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| COAD (tumor) | COAD (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| KICH (tumor) | KICH (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| STAD (tumor) | STAD (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| THCA (tumor) | THCA (normal) |
| HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (tumor) | HAL, HNF4A, HNF1A, PHYH, CANX, F10, LRP1, LMAN1, PROS1, VWF (normal) |
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| TissGeneProg for HAL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HAL |
| TissGeneDrug for HAL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00117 | L-Histidine | Small molecule | Approved|Nutraceutical |
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| TissGeneDisease for HAL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0220992 | Histidinemia | 3 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 1 | GAD |
| umls:C0007125 | Carcinoma, Ehrlich Tumor | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0024591 | Malignant hyperpyrexia due to anesthesia | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027666 | Neoplasms, Radiation-Induced | 1 | GAD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
| umls:C0037286 | Skin Neoplasms | 1 | GAD |
| umls:C0038814 | Sunburn | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0206624 | Hepatoblastoma | 1 | BeFree |
| umls:C0221500 | Effects of heat | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0699893 | Skin carcinoma | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C3249880 | Solar Erythema | 1 | GAD |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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