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| TissGeneSummary for HELLS |
 Gene summary |
| Basic gene information | Gene symbol | HELLS |
| Gene name | helicase, lymphoid-specific | |
| Synonyms | LSH|PASG|SMARCA6 | |
| Cytomap | UCSC genome browser: 10q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289067.1, NM_001289068.1,NM_001289069.1,NM_001289070.1,NM_001289071.1, NM_001289072.1,NM_001289073.1,NM_001289074.1,NM_001289075.1, NM_018063.4, | |
| Description | SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6lymphoid-specific helicaseproliferation-associated SNF2-like | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603946 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000119969 | ||
| HPRD : 07232 | ||
| Vega : OTTHUMG00000018793 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HELLS | |
| BioGPS: 3070 | ||
| Pathway | NCI Pathway Interaction Database: HELLS | |
| KEGG: HELLS | ||
| REACTOME: HELLS | ||
| Pathway Commons: HELLS | ||
| Context | iHOP: HELLS | |
| ligand binding site mutation search in PubMed: HELLS | ||
| UCL Cancer Institute: HELLS | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
| Reference showing the relevant tissue of HELLS | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HELLS |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 0.428977643 | -1.296926203 | 1.725903846 | 6.75E-11 | 9.93E-10 |
| BRCA | -0.27763592 | -2.293821007 | 2.016185088 | 7.05E-30 | 9.32E-29 |
| LUAD | -0.697956972 | -3.459850076 | 2.761893103 | 1.00E-26 | 5.61E-25 |
| LUSC | 0.570507734 | -3.145070698 | 3.715578431 | 1.33E-37 | 4.28E-35 |
| HNSC | 0.219433725 | -0.868043019 | 1.087476744 | 4.56E-07 | 3.81E-06 |
| STAD | 0.478999278 | -1.855650722 | 2.33465 | 5.26E-09 | 2.96E-07 |
| LIHC | -2.131304972 | -4.267998972 | 2.136694 | 8.73E-12 | 1.42E-10 |
| ESCA | 0.950088482 | -1.164547881 | 2.114636364 | 0.000391 | 0.008168145 |
| BLCA | 0.294906186 | -1.943888551 | 2.238794737 | 0.000172 | 0.001685145 |
| KICH | -2.635332972 | -1.379064972 | -1.256268 | 7.96E-05 | 0.000212653 |
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| TissGene-miRNA for HELLS |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HELLS |
| TissGeneSNV for HELLS |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.W225C | THYM | 1 |
| p.R568C | SKCM | 1 |
| p.R675* | BLCA | 1 |
| p.R735K | LIHC | 1 |
| p.A482T | SKCM | 1 |
| p.L275P | LGG | 1 |
| p.K254N | THYM | 1 |
| p.E527A | KIRC | 1 |
| p.R511Q | READ | 1 |
| p.T505A | LUAD | 1 |
| p.N398K | UCEC | 1 |
| p.E229K | COAD | 1 |
| p.P201S | SKCM | 1 |
| p.S179L | UCEC | 1 |
| p.R365C | BLCA | 1 |
| p.K763N | UCEC | 1 |
| p.A342V | COAD | 1 |
| p.G11D | STAD | 1 |
| p.G253D | MESO | 1 |
| p.N764T | UCEC | 1 |
| p.L168F | SKCM | 1 |
| p.I822M | THCA | 1 |
| p.F198S | SKCM | 1 |
| p.D729N | UCEC | 1 |
| p.R510L | HNSC | 1 |
| p.R340Q | READ | 1 |
| p.M86I | SKCM | 1 |
| p.S643N | UCEC | 1 |
| p.E593* | PAAD | 1 |
| p.E87K | SKCM | 1 |
| p.E593X | PAAD | 1 |
| p.E798D | KIRP | 1 |
| p.Q442* | HNSC | 1 |
| p.N114H | UCEC | 1 |
| p.T27S | LUAD | 1 |
| p.R309H | HNSC | 1 |
| p.K103N | BLCA | 1 |
| p.S179L | SKCM | 1 |
| p.R53H | COAD | 1 |
| p.F198V | SKCM | 1 |
| p.T84M | SARC | 1 |
| p.Y651C | STAD | 1 |
| p.K204R | LUAD | 1 |
| p.R224Q | HNSC | 1 |
| p.R707K | STAD | 1 |
| p.P716S | UCEC | 1 |
| p.R510X | LIHC | 1 |
| p.R675* | ACC | 1 |
| p.D426Y | UCEC | 1 |
| p.N517H | COAD | 1 |
| p.L42V | BLCA | 1 |
| p.E98* | UCEC | 1 |
| p.H303Y | BLCA | 1 |
| p.R319W | STAD | 1 |
| p.R803Q | UCEC | 1 |
| p.D629N | ESCA | 1 |
| p.Y65H | STAD | 1 |
| p.I732S | UCS | 1 |
| p.R849Q | CESC | 1 |
| p.I147M | PRAD | 1 |
| p.V210I | COAD | 1 |
| p.P385H | ESCA | 1 |
| p.R803Q | LGG | 1 |
| p.V228I | STAD | 1 |
| p.E818D | UCEC | 1 |
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| TissGeneCNV for HELLS |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HELLS |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AU136737 | AIM1-HELLS | chr6:106978190 | chr10:96347986 | |
| Chimerdb3.0 | ChiTaRs | NA | BE077006 | EIF4G1-HELLS | chr3:184052470 | chr10:96326010 | |
| Chimerdb3.0 | ChiTaRs | NA | CN480729 | RTN3-HELLS | chr11:63526522 | chr10:96313882 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A09Q-01A | HELLS-TBC1D12 | In-frame | Chr10:96348147 | Chr10:96281712 |
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| TissGeneNet for HELLS |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| COAD (tumor) | COAD (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| KICH (tumor) | KICH (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| STAD (tumor) | STAD (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| THCA (tumor) | THCA (normal) |
| HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (tumor) | HELLS, MAGEA6, SUMO2, HDAC2, HDAC1, MYC, CIAO1, DNMT3B, RPAP3, DNMT1, RPAP2 (normal) |
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| TissGeneProg for HELLS |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HELLS |
| TissGeneDrug for HELLS |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HELLS |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026948 | Mycosis Fungoides | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0036920 | Sezary Syndrome | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1518171 | Malignant Conversion | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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