TissGeneSummary for CFHR2 |
Gene summary |
Basic gene information | Gene symbol | CFHR2 |
Gene name | complement factor H-related 2 | |
Synonyms | CFHL2|FHR2|HFL3 | |
Cytomap | UCSC genome browser: 1q31.3 | |
Type of gene | protein-coding | |
RefGenes | NM_005666.2, | |
Description | DDESK59FHR-2H factor (complement)-like 3complement factor H-related protein 2factor H-related gene 2h factor-like 3h factor-like protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600889 | |
HGNC : HGNC | ||
Ensembl : ENSG00000080910 | ||
HPRD : 02933 | ||
Vega : OTTHUMG00000036518 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CFHR2 | |
BioGPS: 3080 | ||
Pathway | NCI Pathway Interaction Database: CFHR2 | |
KEGG: CFHR2 | ||
REACTOME: CFHR2 | ||
Pathway Commons: CFHR2 | ||
Context | iHOP: CFHR2 | |
ligand binding site mutation search in PubMed: CFHR2 | ||
UCL Cancer Institute: CFHR2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CFHR2 | ||
Description by TissGene annotations | Cancer gene TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CFHR2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 10.46379404 | 11.70409404 | -1.2403 | 0.00221 | 0.005565091 |
Top |
TissGene-miRNA for CFHR2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CFHR2 |
TissGeneSNV for CFHR2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E215K | SKCM | 4 |
p.S43F | SKCM | 2 |
p.E49K | SKCM | 2 |
p.P265H | LUAD | 2 |
p.R254* | SKCM | 2 |
p.K148N | STAD | 2 |
p.P90S | SKCM | 2 |
p.G101R | SKCM | 1 |
p.R254Q | LUSC | 1 |
p.N29K | LAML | 1 |
p.I213T | BLCA | 1 |
p.Q183K | KIRC | 1 |
p.K220I | COAD | 1 |
p.S243Y | LUAD | 1 |
p.S61F | COAD | 1 |
p.R232I | BLCA | 1 |
p.C178R | UCEC | 1 |
p.S266R | HNSC | 1 |
p.G31R | SKCM | 1 |
p.S162L | SKCM | 1 |
p.W197R | UCEC | 1 |
p.G195E | ESCA | 1 |
p.I236M | STAD | 1 |
p.T71M | UCEC | 1 |
p.E74Q | COAD | 1 |
p.T47I | BLCA | 1 |
p.Q111L | LUAD | 1 |
p.N225K | LUSC | 1 |
p.G234S | SKCM | 1 |
p.K222X | STAD | 1 |
p.G150V | LUAD | 1 |
p.E269K | BLCA | 1 |
p.S162L | READ | 1 |
p.S231* | SKCM | 1 |
p.F66L | DLBC | 1 |
p.I144V | COAD | 1 |
p.L184F | HNSC | 1 |
p.G158* | LUAD | 1 |
p.C55R | BRCA | 1 |
p.E98Q | ACC | 1 |
p.E269K | SKCM | 1 |
p.S252L | SKCM | 1 |
p.Q196E | LUAD | 1 |
p.V174F | GBM | 1 |
p.E238K | SKCM | 1 |
p.P46H | STAD | 1 |
p.G244V | ESCA | 1 |
p.G244A | LUAD | 1 |
p.S65F | SKCM | 1 |
p.P90L | SKCM | 1 |
p.Y168C | KIRP | 1 |
p.S142C | STAD | 1 |
p.V208L | HNSC | 1 |
p.K222* | STAD | 1 |
p.M214I | SKCM | 1 |
p.I213V | STAD | 1 |
p.S135F | SKCM | 1 |
p.L184P | HNSC | 1 |
p.I127S | PAAD | 1 |
p.C72Y | DLBC | 1 |
p.D24N | SKCM | 1 |
p.W223* | LUAD | 1 |
p.R132W | BLCA | 1 |
p.C140Y | UCEC | 1 |
p.E93K | SKCM | 1 |
p.K82N | LUSC | 1 |
p.E215* | PRAD | 1 |
p.L33I | UCEC | 1 |
p.P206T | UCEC | 1 |
p.F89V | SKCM | 1 |
p.G117E | SKCM | 1 |
p.R254Q | ESCA | 1 |
p.P265S | SKCM | 1 |
p.P152S | SKCM | 1 |
p.R119K | UCEC | 1 |
p.V92L | COAD | 1 |
p.G195X | ESCA | 1 |
p.W77* | SKCM | 1 |
p.E75G | LUSC | 1 |
p.G48E | SKCM | 1 |
p.P152L | SKCM | 1 |
p.C129F | HNSC | 1 |
p.E185Q | BLCA | 1 |
p.G117R | SKCM | 1 |
p.F42C | COAD | 1 |
p.W67* | SKCM | 1 |
p.P62S | SKCM | 1 |
Top |
TissGeneCNV for CFHR2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CFHR2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CFHR2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CFHR2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CFHR2 |
TissGeneDrug for CFHR2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CFHR2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
umls:C2931788 | Atypical Hemolytic Uremic Syndrome | 1 | GAD |