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| TissGeneSummary for HUNK |
 Gene summary |
| Basic gene information | Gene symbol | HUNK |
| Gene name | hormonally up-regulated Neu-associated kinase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 21q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014586.1, | |
| Description | B19hormonally up-regulated neu tumor-associated kinasehormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-Vserine/threonine-protein kinase MAK-V | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606532 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000142149 | ||
| HPRD : 09410 | ||
| Vega : OTTHUMG00000085019 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HUNK | |
| BioGPS: 30811 | ||
| Pathway | NCI Pathway Interaction Database: HUNK | |
| KEGG: HUNK | ||
| REACTOME: HUNK | ||
| Pathway Commons: HUNK | ||
| Context | iHOP: HUNK | |
| ligand binding site mutation search in PubMed: HUNK | ||
| UCL Cancer Institute: HUNK | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHUCEC,UCS | |
| Reference showing the relevant tissue of HUNK | ||
| Description by TissGene annotations | Protective TissGene in RFS Cancer gene Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HUNK |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -4.276749066 | 2.359446934 | -6.636196 | 3.39E-16 | 9.34E-15 |
| PRAD | -1.679702835 | -0.285322066 | -1.394380769 | 5.68E-09 | 7.49E-08 |
| KIRC | 0.455244601 | 2.25188349 | -1.796638889 | 5.04E-23 | 5.04E-22 |
| BRCA | -0.643726891 | 0.653508197 | -1.297235088 | 3.57E-11 | 1.46E-10 |
| BLCA | -1.533128645 | 0.172460829 | -1.705589474 | 0.00139 | 0.009396231 |
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| TissGene-miRNA for HUNK |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-27b-3p | MIMAT0000419 | 0.013 | -0.32 | 60 |
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| TissGeneMut for HUNK |
| TissGeneSNV for HUNK |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R567C | SKCM | 4 |
| p.R168* | UCEC | 2 |
| p.R110Q | LIHC | 2 |
| p.E266K | SKCM | 1 |
| p.A236T | STAD | 1 |
| p.R591C | COAD | 1 |
| p.A433V | SKCM | 1 |
| p.K354* | HNSC | 1 |
| p.E688D | ESCA | 1 |
| p.M671L | KIRP | 1 |
| p.Q677H | HNSC | 1 |
| p.I547F | LIHC | 1 |
| p.D342N | SKCM | 1 |
| p.R501H | GBM | 1 |
| p.I363T | UCS | 1 |
| p.T352A | STAD | 1 |
| p.A316V | STAD | 1 |
| p.H570Y | UCEC | 1 |
| p.R662Q | UCEC | 1 |
| p.Q113E | LUAD | 1 |
| p.E519X | ESCA | 1 |
| p.T260M | HNSC | 1 |
| p.R318C | SKCM | 1 |
| p.R179W | COAD | 1 |
| p.T132M | COAD | 1 |
| p.L355Q | LUAD | 1 |
| p.Q312* | LUAD | 1 |
| p.I363M | ESCA | 1 |
| p.D279E | GBM | 1 |
| p.R673S | LUSC | 1 |
| p.R119C | GBM | 1 |
| p.Y240H | SARC | 1 |
| p.M472I | DLBC | 1 |
| p.K151E | LUSC | 1 |
| p.G215C | LUAD | 1 |
| p.R675H | LUAD | 1 |
| p.R164S | PRAD | 1 |
| p.V571I | LUSC | 1 |
| p.C512F | THYM | 1 |
| p.R485Q | COAD | 1 |
| p.Q713X | COAD | 1 |
| p.K188E | PAAD | 1 |
| p.P654R | ACC | 1 |
| p.R387H | UCEC | 1 |
| p.G709R | SKCM | 1 |
| p.N336K | LIHC | 1 |
| p.G69C | STAD | 1 |
| p.S299F | SKCM | 1 |
| p.R505C | SKCM | 1 |
| p.M558V | LUAD | 1 |
| p.L300F | SKCM | 1 |
| p.R110X | COAD | 1 |
| p.T260M | STAD | 1 |
| p.R501H | STAD | 1 |
| p.H120Q | KIRC | 1 |
| p.S621A | MESO | 1 |
| p.G543R | SKCM | 1 |
| p.K444* | SKCM | 1 |
| p.L697P | DLBC | 1 |
| p.D494N | UCEC | 1 |
| p.D494Y | BLCA | 1 |
| p.S621C | BRCA | 1 |
| p.H578Y | SARC | 1 |
| p.T264M | BLCA | 1 |
| p.K151N | UCEC | 1 |
| p.P219L | BLCA | 1 |
| p.P631S | SKCM | 1 |
| p.R168Q | STAD | 1 |
| p.K402R | BRCA | 1 |
| p.R660Q | BLCA | 1 |
| p.M117I | BLCA | 1 |
| p.S269I | LUSC | 1 |
| p.V44L | LUAD | 1 |
| p.V573M | DLBC | 1 |
| p.A180V | BLCA | 1 |
| p.K444X | SKCM | 1 |
| p.G259R | SKCM | 1 |
| p.L611H | KIRP | 1 |
| p.V434L | CHOL | 1 |
| p.E175K | SKCM | 1 |
| p.P617S | SKCM | 1 |
| p.R298C | KIRC | 1 |
| p.R370P | LUAD | 1 |
| p.R387C | LUAD | 1 |
| p.I118T | HNSC | 1 |
| p.S217L | PRAD | 1 |
| p.S339F | LUSC | 1 |
| p.R567C | BLCA | 1 |
| p.G541V | THYM | 1 |
| p.T325M | STAD | 1 |
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| TissGeneCNV for HUNK |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HUNK |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW937598 | HUNK-CNOT10 | chr21:33312316 | chr3:32810076 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A1J2-01A | HUNK-MRAP | Out-of-Frame | chr21:33297072 | chr21:33678950 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-O1-A52J-01A | HUNK-RUNX1 | Out-of-Frame | chr21:33291015 | chr21:36206706 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-O1-A52J-01A | HUNK-RUNX1 | Out-of-Frame | chr21:33279931 | chr21:36206706 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CR-7372-01A | SIK1-HUNK | Out-of-frame | Chr21:44845287 | Chr21:33312477 |
| TCGAfusionPortal | PRADA | KIRC | TCGA-CJ-5681-01A | HUNK-MAMLD1 | In-frame | Chr21:33246248 | ChrX:149638017 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4398-01A | BRWD1-HUNK | Out-of-frame | Chr21:40641825 | Chr21:33340562 |
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| TissGeneNet for HUNK |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| KICH (tumor) | KICH (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| STAD (tumor) | STAD (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| THCA (tumor) | THCA (normal) |
| HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (tumor) | HUNK, HNF4A, PPP2CA, PPP2R1A, LNX1, CFL1, RABEP1 (normal) |
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| TissGeneProg for HUNK |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HUNK |
| TissGeneDrug for HUNK |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HUNK |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1959635 | Parvovirus B19 (disease) | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0013080 | Down Syndrome | 1 | CTD_human |
| umls:C0019045 | Hemoglobinopathies | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | GAD |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042900 | Vitiligo | 1 | GAD |
| umls:C0151786 | Muscle Weakness | 1 | CTD_human |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1511291 | Breast Cancer Model | 1 | BeFree |
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