TissGeneSummary for AOX1 |
Gene summary |
Basic gene information | Gene symbol | AOX1 |
Gene name | aldehyde oxidase 1 | |
Synonyms | AO|AOH1 | |
Cytomap | UCSC genome browser: 2q33 | |
Type of gene | protein-coding | |
RefGenes | NM_001159.3, | |
Description | aldehyde oxidaseazaheterocycle hydroxylase | |
Modification date | 20141207 | |
dbXrefs | MIM : 602841 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138356 | ||
HPRD : 07537 | ||
Vega : OTTHUMG00000154536 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AOX1 | |
BioGPS: 316 | ||
Pathway | NCI Pathway Interaction Database: AOX1 | |
KEGG: AOX1 | ||
REACTOME: AOX1 | ||
Pathway Commons: AOX1 | ||
Context | iHOP: AOX1 | |
ligand binding site mutation search in PubMed: AOX1 | ||
UCL Cancer Institute: AOX1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of AOX1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for AOX1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 6.529872216 | 8.861790216 | -2.331918 | 1.76E-06 | 8.84E-06 |
THCA | -2.194283547 | 2.464775775 | -4.659059322 | 1.59E-21 | 8.59E-20 |
PRAD | 1.89913337 | 3.979060293 | -2.079926923 | 4.82E-16 | 8.31E-14 |
LUAD | 0.212348423 | 1.976931182 | -1.764582759 | 7.88E-11 | 4.79E-10 |
KICH | -1.796209784 | 3.527806216 | -5.324016 | 6.72E-10 | 4.39E-09 |
KIRP | 1.701240341 | 4.785315341 | -3.084075 | 9.36E-06 | 3.94E-05 |
BLCA | -2.328890415 | 2.268441164 | -4.597331579 | 1.53E-10 | 3.40E-08 |
HNSC | -0.965870342 | 1.371408728 | -2.33727907 | 1.43E-10 | 2.85E-09 |
LUSC | -1.048212294 | 2.360607314 | -3.408819608 | 1.44E-22 | 2.32E-21 |
BRCA | 0.135063971 | 2.969318357 | -2.834254386 | 1.51E-31 | 2.15E-30 |
COAD | -1.414218553 | 0.900531447 | -2.31475 | 2.60E-06 | 1.34E-05 |
STAD | -1.340972159 | 0.798780966 | -2.139753125 | 1.90E-05 | 0.000196917 |
Top |
TissGene-miRNA for AOX1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for AOX1 |
TissGeneSNV for AOX1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M55I | SKCM | 4 |
p.D138N | SKCM | 2 |
p.A507V | GBM | 2 |
p.D666N | SKCM | 2 |
p.R833C | SKCM | 2 |
p.S476F | SKCM | 2 |
p.G510E | SKCM | 2 |
p.P1197S | CESC | 1 |
p.A1102V | LGG | 1 |
p.S652F | SKCM | 1 |
p.V1038A | LUSC | 1 |
p.A320S | LUAD | 1 |
p.S521G | COAD | 1 |
p.F522L | CHOL | 1 |
p.E1078K | LUAD | 1 |
p.M1047I | SKCM | 1 |
p.P778S | SKCM | 1 |
p.C165R | THCA | 1 |
p.V1091E | BRCA | 1 |
p.R98K | SKCM | 1 |
p.D182Y | LUSC | 1 |
p.R1061H | GBM | 1 |
p.I390T | HNSC | 1 |
p.H68R | LIHC | 1 |
p.D289Y | ESCA | 1 |
p.T932A | LUAD | 1 |
p.R240I | PAAD | 1 |
p.P260S | SKCM | 1 |
p.F9C | KIRC | 1 |
p.L1094I | READ | 1 |
p.F428L | STAD | 1 |
p.G450E | SKCM | 1 |
p.R833C | BLCA | 1 |
p.N1069I | SKCM | 1 |
p.G464V | LUAD | 1 |
p.Q767E | BRCA | 1 |
p.G637S | UCEC | 1 |
p.A493T | UCEC | 1 |
p.G93E | SKCM | 1 |
p.A824V | STAD | 1 |
p.Y964F | LUAD | 1 |
p.H744P | SKCM | 1 |
p.G48S | HNSC | 1 |
p.E708D | ESCA | 1 |
p.N794S | UCEC | 1 |
p.E6Q | BLCA | 1 |
p.L1034F | LIHC | 1 |
p.G637C | STAD | 1 |
p.E967K | BLCA | 1 |
p.V671G | SKCM | 1 |
p.N1000K | PRAD | 1 |
p.G877S | UCEC | 1 |
p.I533T | SKCM | 1 |
p.D649N | SKCM | 1 |
p.I1187N | HNSC | 1 |
p.H1180R | LIHC | 1 |
p.R802H | LUSC | 1 |
p.E724V | OV | 1 |
p.R951Q | UCEC | 1 |
p.E435D | READ | 1 |
p.E24K | CESC | 1 |
p.Q1157H | SARC | 1 |
p.G1140A | LIHC | 1 |
p.R921H | KIRC | 1 |
p.E871Q | BLCA | 1 |
p.P1081L | LUSC | 1 |
p.P219S | SKCM | 1 |
p.D841G | LIHC | 1 |
p.R67K | HNSC | 1 |
p.M955T | LIHC | 1 |
p.H1042Y | SARC | 1 |
p.E948Q | LUSC | 1 |
p.K474N | LUSC | 1 |
p.D1317N | HNSC | 1 |
p.I1195V | LIHC | 1 |
p.G1272R | LUAD | 1 |
p.G853E | SKCM | 1 |
p.R833C | READ | 1 |
p.G571S | SKCM | 1 |
p.G1165R | LGG | 1 |
p.R1021H | LUAD | 1 |
p.A1166T | OV | 1 |
p.L739I | UCEC | 1 |
p.E938K | SKCM | 1 |
p.M1149I | SKCM | 1 |
p.V86I | KICH | 1 |
p.G444E | SKCM | 1 |
p.H557N | UCEC | 1 |
p.G846V | LUAD | 1 |
p.F202L | LUAD | 1 |
p.G853R | SKCM | 1 |
p.E215X | THYM | 1 |
p.E1218K | LUSC | 1 |
p.G815A | LUSC | 1 |
p.A664V | STAD | 1 |
p.E1111K | UCEC | 1 |
p.S626Y | UCEC | 1 |
p.L294M | LUAD | 1 |
p.T613N | STAD | 1 |
p.L148M | ESCA | 1 |
p.E1132K | BLCA | 1 |
p.F662S | STAD | 1 |
p.S1223Y | READ | 1 |
p.G637S | COAD | 1 |
p.S984F | STAD | 1 |
p.K276N | SKCM | 1 |
p.T1230I | UCEC | 1 |
p.G464* | LUAD | 1 |
p.G764R | SKCM | 1 |
p.Q1203L | CHOL | 1 |
p.M223I | LUAD | 1 |
p.L903F | SKCM | 1 |
p.E596K | SKCM | 1 |
p.V323A | UCEC | 1 |
p.L759I | UCEC | 1 |
p.G454D | UCEC | 1 |
p.L504W | LIHC | 1 |
p.S1259* | BLCA | 1 |
p.P926L | SKCM | 1 |
p.S287Y | UCEC | 1 |
p.V1188L | LGG | 1 |
p.A824P | LUAD | 1 |
p.A664V | CESC | 1 |
p.Q975L | LUSC | 1 |
p.T197K | PRAD | 1 |
p.R58Q | STAD | 1 |
p.G1165E | SKCM | 1 |
p.E1160K | GBM | 1 |
p.D1186G | LUSC | 1 |
p.R951X | READ | 1 |
p.G1048R | SKCM | 1 |
p.M753V | LUSC | 1 |
p.Q1225K | LUAD | 1 |
p.G47E | SKCM | 1 |
p.D1035Y | ESCA | 1 |
p.D1234G | LUAD | 1 |
p.S916P | HNSC | 1 |
p.S426L | STAD | 1 |
p.S985F | SKCM | 1 |
p.R906Q | HNSC | 1 |
p.G846R | LUAD | 1 |
p.T1079I | UCEC | 1 |
p.G342E | SKCM | 1 |
p.P1224S | SKCM | 1 |
p.A982V | SARC | 1 |
p.L381V | OV | 1 |
p.R36Q | COAD | 1 |
p.P1081T | LUAD | 1 |
p.F1274Y | HNSC | 1 |
p.I974N | LUSC | 1 |
p.I349N | STAD | 1 |
p.G1048R | STAD | 1 |
p.I1032T | SKCM | 1 |
p.N1182T | UCEC | 1 |
p.D960H | HNSC | 1 |
p.M745I | LUAD | 1 |
p.I627N | LUAD | 1 |
p.Y542C | UCEC | 1 |
p.Y463C | LUAD | 1 |
p.N268S | LIHC | 1 |
p.S1288C | SKCM | 1 |
p.G450E | LUSC | 1 |
p.E451* | BLCA | 1 |
p.A320V | THYM | 1 |
p.K1321E | LUAD | 1 |
p.V512L | BRCA | 1 |
p.C114Y | SKCM | 1 |
p.R619T | HNSC | 1 |
p.A507V | LGG | 1 |
p.S287Y | COAD | 1 |
Top |
TissGeneCNV for AOX1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for AOX1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AV653907 | AOX1-ALB | chr2:201535676 | chr4:74283944 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-Q9-A6FW-01A | PGAP1-AOX1 | CDS-5'UTR | chr2:197740469 | chr2:201473706 |
Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2X-11A | AOX1-ALB | 5'UTR-CDS | chr2:201534333 | chr4:74280832 |
Top |
TissGeneNet for AOX1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for AOX1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for AOX1 |
TissGeneDrug for AOX1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for AOX1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0268118 | Xanthinuria, Type I | 2 | BeFree |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
umls:C0025517 | Metabolic Diseases | 1 | BeFree |
umls:C0029456 | Osteoporosis | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0040822 | Tremor | 1 | BeFree |
umls:C0268119 | Combined molybdoflavoprotein enzyme deficiency | 1 | BeFree |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C3887873 | Hearing Loss | 1 | GAD |