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| TissGeneSummary for FOXA1 |
 Gene summary |
| Basic gene information | Gene symbol | FOXA1 |
| Gene name | forkhead box A1 | |
| Synonyms | HNF3A|TCF3A | |
| Cytomap | UCSC genome browser: 14q12-q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004496.3, | |
| Description | HNF-3-alphaHNF-3ATCF-3Aforkhead box protein A1hepatocyte nuclear factor 3-alphatranscription factor 3A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602294 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129514 | ||
| HPRD : 03801 | ||
| Vega : OTTHUMG00000140253 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOXA1 | |
| BioGPS: 3169 | ||
| Pathway | NCI Pathway Interaction Database: FOXA1 | |
| KEGG: FOXA1 | ||
| REACTOME: FOXA1 | ||
| Pathway Commons: FOXA1 | ||
| Context | iHOP: FOXA1 | |
| ligand binding site mutation search in PubMed: FOXA1 | ||
| UCL Cancer Institute: FOXA1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of FOXA1 | ||
| Description by TissGene annotations | Cancer gene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0032355 | response to estradiol | 16087863 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16331276 | GO:0032355 | response to estradiol | 16087863 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16331276 |
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| TissGeneExp for FOXA1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 5.72575697 | 3.680199076 | 2.045557895 | 2.54E-08 | 8.07E-08 |
| COAD | 1.633620668 | 3.497520668 | -1.8639 | 1.07E-05 | 4.87E-05 |
| HNSC | 0.55595591 | 2.767181491 | -2.211225581 | 3.73E-07 | 3.20E-06 |
| PRAD | 7.286497591 | 5.446243745 | 1.840253846 | 2.72E-06 | 1.76E-05 |
| LUAD | 4.174533135 | 3.120529687 | 1.054003448 | 2.26E-10 | 1.29E-09 |
| KICH | -5.422973486 | -3.879741486 | -1.543232 | 0.00294 | 0.005832367 |
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| TissGene-miRNA for FOXA1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOXA1 |
| TissGeneSNV for FOXA1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I176M | BRCA | 2 |
| p.N135S | SKCM | 2 |
| p.S28P | UCEC | 1 |
| p.F254V | PRAD | 1 |
| p.M59I | BLCA | 1 |
| p.D226G | PRAD | 1 |
| p.D249V | PRAD | 1 |
| p.W214C | BRCA | 1 |
| p.D226N | PRAD | 1 |
| p.A342V | PAAD | 1 |
| p.S361R | TGCT | 1 |
| p.H220Q | PRAD | 1 |
| p.A159T | SARC | 1 |
| p.I176M | LUAD | 1 |
| p.A144V | UCEC | 1 |
| p.P205L | BLCA | 1 |
| p.M253K | PRAD | 1 |
| p.D226N | BRCA | 1 |
| p.S401T | KIRP | 1 |
| p.A81E | SKCM | 1 |
| p.H247Y | PRAD | 1 |
| p.T52I | PAAD | 1 |
| p.A458T | ESCA | 1 |
| p.H247Y | BRCA | 1 |
| p.S95T | PRAD | 1 |
| p.A442T | THYM | 1 |
| p.F266C | PRAD | 1 |
| p.N256I | BRCA | 1 |
| p.S441T | LGG | 1 |
| p.R261G | PRAD | 1 |
| p.A186V | UCEC | 1 |
| p.I176V | BRCA | 1 |
| p.D158N | LUSC | 1 |
| p.M41I | BLCA | 1 |
| p.S146F | LGG | 1 |
| p.A133T | PAAD | 1 |
| p.V101M | GBM | 1 |
| p.R213H | UCEC | 1 |
| p.S174L | HNSC | 1 |
| p.F224L | BLCA | 1 |
| p.P457S | HNSC | 1 |
| p.A153V | BRCA | 1 |
| p.D226G | BRCA | 1 |
| p.E24K | SKCM | 1 |
| p.G9V | LUAD | 1 |
| p.K237M | COAD | 1 |
| p.S27P | LIHC | 1 |
| p.F266I | BRCA | 1 |
| p.S250F | BRCA | 1 |
| p.P359S | SKCM | 1 |
| p.D226N | BLCA | 1 |
| p.G117C | SARC | 1 |
| p.Q271K | COAD | 1 |
| p.M253T | PRAD | 1 |
| p.G112D | LGG | 1 |
| p.R261C | PRAD | 1 |
| p.V29I | GBM | 1 |
| p.A83T | COAD | 1 |
| p.D14H | TGCT | 1 |
| p.F266L | PRAD | 1 |
| p.V229I | UCEC | 1 |
| p.P452A | GBM | 1 |
| p.F266S | PRAD | 1 |
| p.E11K | LUAD | 1 |
| p.L148V | ACC | 1 |
| p.V468F | LGG | 1 |
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| TissGeneCNV for FOXA1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOXA1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA371447 | OSBPL3-FOXA1 | chr7:24846412 | chr14:38060578 | |
| TCGAfusionPortal | PRADA | PRAD | TCGA-KK-A6E4-01A | ERBB3-FOXA1 | 3UTR-5UTR | Chr12:56497283 | Chr14:38069245 |
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| TissGeneNet for FOXA1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| COAD (tumor) | COAD (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| KICH (tumor) | KICH (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| STAD (tumor) | STAD (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| THCA (tumor) | THCA (normal) |
| FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (tumor) | FOXA1, BRCA1, ELAVL1, ONECUT1, HIST3H3, SUMO2, IGFBP1, AR, SFTPD, HDAC7, APOB, ERBB3, AHR, TLE1, TF, EPHX1, AMBP, FOXA2, MUC4, SEZ6L2, UPK2 (normal) |
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| TissGeneProg for FOXA1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOXA1 |
| TissGeneDrug for FOXA1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOXA1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 31 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 30 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 21 | BeFree |
| umls:C0600139 | Prostate carcinoma | 20 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 13 | BeFree,CTD_human,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 6 | BeFree |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0684249 | Carcinoma of lung | 6 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree,LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 4 | BeFree,CTD_human,LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
| umls:C0015695 | Fatty Liver | 2 | BeFree,CTD_human |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | BeFree |
| umls:C0038476 | Supernumerary structure | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0220650 | Metastatic malignant neoplasm to brain | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 1 | BeFree |
| umls:C0278838 | Prostate cancer recurrent | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0279565 | Invasive Lobular Breast Carcinoma | 1 | BeFree |
| umls:C0282612 | Prostatic Intraepithelial Neoplasias | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0851887 | Adenoviral infections | 1 | BeFree |
| umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
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